Protein Alignment CG18659 and DENND2D

DIOPT Version :10

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_006710984.2
• Gene: DENND2D / 79961
• HGNCID: 26192
• Length: 485
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 108/423 - (25%)
• Similarity: 188/423 - (44%)
• Gaps: 71/423 - (16%)

  Fly    42 VIVESFPE------GFRDQE--VLTGIPSFAFP-----CDTTSTSVQTYSFVHTTGDSKWRFGFC 93
            :|...||:      |.:::|  :|..||.|.||     ...|....:|:|||.|..|...:.|:|
Human    88 IITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYC 152

  Fly    94 RQ------DPRTNTAMVLITYLPWHDTFLKLL---------------PVLAELRRTD-PNGFRTF 136
            |:      .||......:|:.:.....|.|:|               |.:..||... |...:|.
Human   153 RRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTV 217

  Fly   137 LSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAM 201
            ..:::   |||          :|....:..|||...|    |:.:.:...:.:..::::.:||:.
Human   218 TLKSF---IPD----------SGTEFISLTRPLDSHL----EHVDFSSLLHCLSFEQILQIFASA 265

  Fly   202 LAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLET 266
            :.||:|||.:..|..||.||.||.|.|||..|.|.:|||:|......:..|.|:::||.....:.
Human   266 VLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQE 330

  Fly   267 VTSDELGEVVILN-CDTKIFESPFDDVHNLP----TEIVSQLKKHLNH--THDHIGDRISKIFLN 324
            |....:.||:::| |:.....|..|:...||    .:|:..|.:.:|.  |.:.|.:.:|..|:.
Human   331 VMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQ 395

  Fly   325 ALVQLIGGYRDAVEYHENSK-TFNSQKFIESRPAHL-RPFLAKMMDLQIFAQFIDDRLTMLNSGL 387
            ..|:::|.|...::...|.: .|..:.|.::..:.. |.|:.|.:..|:|:.||.:.....|...
Human   396 FFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPA 460

  Fly   388 GFSDEFELETVRYAEKKKRGRNYAIMKNLKDKT 420
            |:   |:.:.:.|.|:||:       |..::||
Human   461 GY---FQQKILEYEEQKKQ-------KKPREKT 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	20/65 (31%)
		DENN	98..282	CDD:460461	52/200 (26%)
		dDENN	315..379	CDD:129037	15/65 (23%)
DENND2D	XP_006710984.2	uDENN	64..156	CDD:214824	21/67 (31%)
		DENN	163..347	CDD:460461	52/200 (26%)
		dDENN	386..451	CDD:129037	15/64 (23%)