Protein Alignment CG18659 and DENND1C

DIOPT Version :9

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_024307495.1
• Gene: DENND1C / 79958
• HGNCID: 26225
• Length: 938
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 244/842 - (28%)
• Similarity: 355/842 - (42%)
• Gaps: 202/842 - (23%)

  Fly    22 TPGLERGTSSRSGGPAV---------PAGV-----IVESFPEGFRDQEVLTGIPSFAFPCDT--- 69
            ||    ..|.|.|.|||         ||.:     |:..||..|||||.:..:|.|.||.|.
Human   137 TP----SASHRGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 197

  Fly    70 -TSTSVQTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAELRRTDP-NG 132
             .|.:||.::|..|......||||||....|.:.:.::::|||.:.|.|||..:.:|...|. ..
Human   198 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTE 262

  Fly   133 FRTFLSEAYNQGI--PDCGGSLK----VYYSAGQS-----------HFTFERPLQFQLPSMPENH 180
            ....|...:.|.:  |.....|:    |..|:||.           ...|..|...:|||:|||.
Human   263 AEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENR 327

  Fly   181 NLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEF 245
            ||......|..:.::.:|||:|||||::.|:..|..|:||:.|:.|.||||.|:|:.||.||...
Human   328 NLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHL 392

  Fly   246 KDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKKHLNHT 310
            .||..|||||||||...:.|.|....|.:||:||.|....|:.|:||..||.::||.|:..|...
Human   393 LDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLRLRLRKV 457

  Fly   311 HDHIGDRISKIFLNALVQLIGGYRDAVEYHENSK-TFNSQKFIESRP-AHLRPFLAKMMDLQIFA 373
            ....|:.:|::||.|...|.||||||:....... ||:.:.|:..:| |.|:.|..:.:.||:|.
Human   458 ALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFK 522

  Fly   374 QFIDDRLTMLNSGLGFSDEFELETV-------------RYAEKKKRGRNYAIMKNLKDKTNPAVK 425
            |||:.||..||.|.||||:||.|..             .:|:..|:|.. |::.::|.||.||||
Human   523 QFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG-ALLHSVKAKTQPAVK 586

  Fly   426 SAVKSVKEGSRGMKT--AYKGFKTKLRENGN--------------QFGGTHFHFGLGSPNHSDR- 473
            :..:|.|.|.:|:::  .||...:.|:..|:              |......|||...|....|
Human   587 NMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRR 651

  Fly   474 ---PDGTSGGYVRGGKAIGAAHHSAP-------SSPVTS-KRLDGIASVTG--SSGSGGSGAREP 525
               .:|||.....|...:.......|       ||.:.| :.||.::.:..  |.|:..:|:..|
Human   652 RQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRP 716

  Fly   526 REFL---RRG-------------------------PVPLAMSSSSSHIQPNGHAYGASAGAHYGH 562
            .:.|   .||                         |.||::
Human   717 SQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSL------------------------ 757

  Fly   563 HLAASPAVSSASSL--CSSSEMNLS--------QELQNHPLFKTPAVDRSL----------KPNA 607
                 |::.:||||  .|||:.:.|        ||:.:.....|.:.|.|:          :|..
Human   758 -----PSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSPLTEPLI 817

  Fly   608 EHRRGAAPPARPPPPQSTPASYYNHPYAAHPHVESKPPRHTS--TPTRPR-------QPL-PTAD 662
            .|...:...|.....|..|.     |:.:....|..||....  .||:|.       ||| |::|
Human   818 LHLTPSHKAAEDSTAQENPT-----PWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQPLDPSSD 877

  Fly   663 SSSFDSPPDVQSPP---------IPPRRQ-GSSNAIVAATAAAVSAEISKLERNCWKDEPGN 714
            .||.:.|.  ..||         :.||.: |:.|:....|:            ||.|.:|.:
Human   878 PSSLEDPR--ARPPKALLAERAHLQPREEPGALNSPATPTS------------NCQKSQPSS 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	33/90 (37%)
		DENN	98..282	CDD:280329	72/201 (36%)
		dDENN	315..379	CDD:129037	25/65 (38%)
DENND1C	XP_024307495.1	uDENN	150..224	CDD:214824	25/73 (34%)
		DENN	230..430	CDD:214823	72/199 (36%)
		dDENN	462..528	CDD:129037	25/65 (38%)
		DUF3295	<748..>930	CDD:314547	48/226 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158329
Domainoid	1	1.000	137	1.000	Domainoid score	I4893
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm42234
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	LDO	PTHR13196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.700