DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18659 and Dennd1c

DIOPT Version :10

Sequence 1:NP_665880.2 Gene:CG18659 / 35929 FlyBaseID:FBgn0027561 Length:908 Species:Drosophila melanogaster
Sequence 2:NP_705779.1 Gene:Dennd1c / 70785 MGIID:1918035 Length:786 Species:Mus musculus


Alignment Length:874 Identity:240/874 - (27%)
Similarity:360/874 - (41%) Gaps:226/874 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |||........:|:::.|......||....            |:..||..|::||.:..:|.|.|
Mouse     1 MGSTETRHPPAMFDWFFEAGCPNSLEEDPP------------ILRQFPPDFQEQEAMQMVPRFCF 53

  Fly    66 PCD----TTSTSVQTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAEL- 125
            |.|    ..|.:||.::|..|......||||||......:.:.::::.||.:.|.|:|..:.:| 
Mouse    54 PFDIEREPPSPAVQHFTFALTDLVGNRRFGFCRLRAGARSCLCILSHFPWFEVFYKILNNVGDLL 118

  Fly   126 --------------------------RRTDPNGFRTFLSEAYNQGI-PDCGGSLKVYYSAGQSHF 163
                                      .|::.:...|..||.   || |...|:.|:.       .
Mouse   119 AQNQVAEAEELLQNLQQHPLLGPRFSGRSEMDSSITVRSEC---GILPPALGNSKLL-------S 173

  Fly   164 TFERPLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFL 228
            .|..|....|||:|||.||......|..:.::.:|||:|||||::.|:..|..|::|:.|:.|.|
Mouse   174 CFVAPDAASLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALL 238

  Fly   229 YPMVWQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVH 293
            |||.|:|:.||.||....||..|||||||||...:.|.|....|.:||:||.|:...|:|||||.
Mouse   239 YPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHGSLAERVREKALEDVVVLNADSNTLETPFDDVQ 303

  Fly   294 NLPTEIVSQLKKHLNHTHDHIGDRISKIFLNALVQLIGGYRDA-VEYHENSKTFNSQKFIESRP- 356
            .||.::||.|:..|.......|:.:|::||.....|.|||||| |.......||:.:.|:..:| 
Mouse   304 ALPPDVVSLLRLRLRKVALSPGEGVSRLFLKVQALLFGGYRDALVCIPGQPVTFSEEAFLAQKPG 368

  Fly   357 AHLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELE----------TVR----YAEKKKRG 407
            |.|:.|..|.:.||:|.|||:.||..||:|.||||:||.|          |:|    :.:..|:|
Mouse   369 APLQAFHKKAVHLQLFKQFIESRLEKLNAGEGFSDQFEQEIIACRGASSGTLRSYQLWVDSLKKG 433

  Fly   408 RNYAIMKNLKDKTNPAVKSAVKS-----------VKEGSRGMKTAYKGFKTKLRENGNQFGGTHF 461
            .: |::.::|.||.|||::..:|           .|.|.:||:..   ...|..::|.|.||:  
Mouse   434 SD-ALLHSMKTKTQPAVRNMYRSGDSLQEYCASKAKSGLKGMQNL---LTIKDGDSGLQRGGS-- 492

  Fly   462 HFGLGSPNHSDRPDGTSGGYVRGGKAIGAAHHSAPSSPV-TSKRLDGIASVTGSSGSGGSGAREP 525
               |.:|:.:.|.|       |..:.:..:.|...:.|: .|:||           ....|..||
Mouse   493 ---LRTPSLTSRSD-------RLQQRLPISQHFGQNRPLRPSRRL-----------KTEEGPSEP 536

  Fly   526 -REFLRRGPVPLAMSSSSSHIQPNGHAYGASAGAHYGHHLAASPAVSSASSLCSSSEMNLSQELQ 589
             ||   |.|   .:|...:.   |..|.....|:..|                |..|::|..|:.
Mouse   537 LRE---RSP---TLSPGDTQ---NPWAEDTLDGSFLG----------------SGEELDLLSEIL 576

  Fly   590 NHPLFKTPAVD--RSLKPNAEHRRGAA----------PPARP-----------PPP--------- 622
            :....:|.:.|  |:.:.....:||||          |...|           |.|         
Mouse   577 DSLNVETKSGDLQRASQSLDCCQRGAASESCSSLPDIPVGLPWQLEEDKRSQDPQPWSLPGDLSL 641

  Fly   623 -QSTPAS---YYNHPYAAHPHVESKPPRHTSTPTRPRQPLPTADSSSFDSP-------PDVQSPP 676
             |.||.|   .|:....:.|..:|.|.:....|:     |...|.....||       |...|||
Mouse   642 LQDTPFSEVVSYSKNSCSQPFQQSPPSQGDPGPS-----LSKLDPRPSQSPCPKLLRVPTRHSPP 701

  Fly   677 IPPRRQGSSNAIVAATAAAVSAEISKLERNCWKDEPGNDSVRSSNASSSSATSSSSGASFVTAAS 741
            ..|:       ::.:|                  ||.:|:|:...:.||.:.|.|:         
Mouse   702 ESPQ-------LLVST------------------EPNSDAVQRLQSISSPSCSHSA--------- 732

  Fly   742 TFSHLNVSDPPIPTPRAKREQQ--QPLED 768
                   .:|....|:....|.  ||||:
Mouse   733 -------ENPRNQPPQVLLGQACVQPLEE 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18659NP_665880.2 uDENN 10..95 CDD:214824 25/88 (28%)
DENN 98..282 CDD:460461 68/211 (32%)
dDENN 315..379 CDD:129037 26/65 (40%)
Dennd1cNP_705779.1 uDENN 13..87 CDD:214824 25/85 (29%)
DENN 91..293 CDD:214823 69/211 (33%)
dDENN 325..391 CDD:129037 26/65 (40%)
FXDXF motif. /evidence=ECO:0000250|UniProtKB:Q8TEH3 401..405 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..553 24/103 (23%)
Clathrin box. /evidence=ECO:0000250|UniProtKB:Q8TEH3 570..579 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..741 24/133 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..786
Blue background indicates that the domain is not in the aligned region.

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