Protein Alignment CG18659 and DENND2B

DIOPT Version :9

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_011518611.1
• Gene: DENND2B / 6764
• HGNCID: 11350
• Length: 1187
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 120/473 - (25%)
• Similarity: 195/473 - (41%)
• Gaps: 80/473 - (16%)

  Fly    10 KKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRD-------QEVLTGIPSFAFP- 66
            ::|||::..|:    |::..|..:..|.|.     ..||:..|.       :|.|..||.|.||
Human   724 RELFEYFVVVS----LKKKPSRNTYLPEVS-----YQFPKLDRPTKQMREAEERLKAIPQFCFPD 779

  Fly    67 ----CDTTSTSVQTYSFVHTTGDSKWRFGFCR--------------------------QDPRTNT 101
                ...:..|.:|:||:.|..|...|||:||                          :.||...
Human   780 AKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLFALLEWRWIKKGRKEAKKGMPSGKGPRLPE 844

  Fly   102 AMVLITYLPWHDTFLKLLPVLAELRRTDPNGFRTFLSEAYNQGIPDCGGSLKV---YYSAGQSHF 163
            ...:|:.|.....|.|:|..:...|.........|:........|..|.::||   ...||....
Human   845 VYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVL 909

  Fly   164 TFERPLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFL 228
            ...||:..:|    |:.:....:..:..:::|.:||::|.|||:||.:..|..||||..|..|.|
Human   910 ELRRPMDSRL----EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 970

  Fly   229 YPMVWQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVH 293
            ||..|||.||||||....|.:..|.|:|:|:....|..:....:.|.:::|..:..|....||..
Human   971 YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDED 1035

  Fly   294 N-LPTEIVSQLKKHLNHTHDHIGD---------------RISKIFLNALVQLIGGYR-DAVEYHE 341
            . ||.::.:.|::.|...::.|..               .:|::|:...|:.:|.|. ...:..:
Human  1036 TLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEK 1100

  Fly   342 NSKTFNSQKFIES-RPAHLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEK-- 403
            ..:.|..:.|.:| ....:|.||...|:.|:||.||.||........|.   ||....:|.|:
Human  1101 GERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL---FEQRVEQYLEELP 1162

  Fly   404 --KKRGRNYAIMKNLKDK 419
              ::.|.| ..::.|.:|
Human  1163 DTEQSGMN-KFLRGLGNK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	29/122 (24%)
		DENN	98..282	CDD:280329	54/186 (29%)
		dDENN	315..379	CDD:129037	17/80 (21%)
DENND2B	XP_011518611.1	uDENN	727..814	CDD:214824	28/95 (29%)
		DENN	841..1022	CDD:280329	53/184 (29%)
		dDENN	1073..1139	CDD:129037	17/65 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810