Protein Alignment CG18659 and DENND1A

DIOPT Version :9

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_011517184.1
• Gene: DENND1A / 57706
• HGNCID: 29324
• Length: 1085
• Species: Homo sapiens
• Alignment Length: 1059
• Identity: 290/1059 - (27%)
• Similarity: 401/1059 - (37%)
• Gaps: 339/1059 - (32%)

  Fly     7 NDVKKL---------FEFWCEVT-PTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIP 61
            |:.:|:         ||.:.||. |..|   ||.|   .|.|.     ..|||.:.|||||..:.
Human    13 NETRKVCLWQNPETTFEVYVEVAYPRTG---GTLS---DPEVQ-----RQFPEDYSDQEVLQTLT 66

  Fly    62 SFAFPCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVL 122
            .|.||....|.:|    |.::||.|..|||.||||||......:...:::||||.:.|.|||.:|
Human    67 KFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNIL 131

  Fly   123 AE-LRRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQLPSMPENHNLNLYY 186
            |: ..:...|.:...|...:...|||.|  :.|:.|. .|:||.  |...:|||:|||.||..|:
Human   132 ADYTTKRQENQWNELLETLHKLPIPDPG--VSVHLSV-HSYFTV--PDTRELPSIPENRNLTEYF 191

  Fly   187 NFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFKDYLGA 251
            ..|:...|:.::|:||.||||:.....|..|::||..:.|.||||.|||::|||||....||..|
Human   192 VAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCA 256

  Fly   252 PMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKKHLNHTHDHIGD 316
            |||||||:...::|.|.:..|.:|||||.||...|:||||:.:||.:::|.||..|.......||
Human   257 PMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGD 321

  Fly   317 RISKIFLNALVQLIGGYRDAVEYH-ENSKTFNSQKFIES-RPAHLRPFLAKMMDLQIFAQFIDDR 379
            .:::.||.|.....|.||:|::.. |...||..:.|:.. |...:|.||.....||:|.||||.|
Human   322 GVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGR 386

  Fly   380 LTMLNSGLGFSDEF--ELETVRYAEKKK---------RGRNYAIMKNLKDKTNPAVKSAVKSVKE 433
            |.:||||.||||.|  |:....||...|         |..:.||:..:|.|.|||:|:..|..|:
Human   387 LDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKD 451

  Fly   434 GSR-GMKTAYKGFKTK-LRENG------NQFGGT--------------------HFHFG------ 464
            .:: |:|......|.| :.|||      .|...|                    ..|||
Human   452 HAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQLQRLR 516

  Fly   465 -------------------------------------LGSPNH----------------SD---- 472
                                                 :.||.|                ||
Human   517 PTRPPPKIQRSRPVRPPRPHVVKRPKSNIAVEGRRTSVPSPEHLVKPLRHYAVFLSEDSSDDECQ 581

  Fly   473 RPDGTSGGYVRGGKAIGAAHHSAP---SSPVTSKRLDGIASVTGSSGSGGSGAREPREFLRR--G 532
            |.:|.|.|:..      :...|||   ..|..:.|        .|..:.|..|..|.:.:|:  |
Human   582 REEGPSSGFTE------SFFFSAPFEWPQPYRTLR--------ESDSAEGDEAESPEQQVRKSTG 632

  Fly   533 PVPLAMSSSSS---------------HIQPNGHAYGASAGAHYGHHLAASPAVSSASSLCSSSEM 582
            |||.....::|               .:||.|.|.                         |..::
Human   633 PVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAK-------------------------SLEDL 672

  Fly   583 NLSQELQNHP-LFKTPAVDRSLKPNAEHRRGAAPPARPPPPQSTPASYYNHPY----------AA 636
            ...::|:..| .|....:|..   .:|..||.           |.|....|||          .|
Human   673 RAPKDLREQPGTFDYQRLDLG---GSERSRGV-----------TVALKLTHPYNKLWSLGQDDMA 723

  Fly   637 HPHVESKPP------------RHTSTPTRPRQ-------------PLPTADSSSFDSP-----PD 671
            .|   ||||            ...:.|.||:.             |.||..|.:...|     |:
Human   724 IP---SKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEEVPTPTLGSITIPRPQGRKTPE 785

  Fly   672 ---VQSPPIPPRRQGSSNAIVAATAAAVSAEISKLERNCWKDEPGNDSVRSSNASSSSATSSSSG 733
               |..||||      ..|.:.|..||:.....:|:.:           |...|:.|....
Human   786 LGIVPPPPIP------RPAKLQAAGAALGDVSERLQTD-----------RDRRAALSPGLL---- 829

  Fly   734 ASFVTAASTFSHLNVSDPPIPTPRAKREQQQPLE-------DSMNDLISLDDSNNTSFDLEDFDP 791
                              |...|:...|..|||.       .|.:.|::|
Human   830 ------------------PGVVPQGPTELLQPLSPGPGAAGTSSDALLAL--------------- 861

  Fly   792 LNQNARPLPPLSTAFAKKCSTLPAGVNSSVVASSVSNPLYPYFAPKHMATVAAVTGRTPPMHP-- 854
                   |.|||||::.  ||||    |.....:|:.|..|.|:.....|.....  .||::|
Human   862 -------LDPLSTAWSG--STLP----SRPATPNVATPFTPQFSFPPAGTPTPFP--QPPLNPFV 911

  Fly   855 ------PPQIQRNTIAAKP 867
                  ||.:...:..|.|
Human   912 PSMPAAPPTLPLVSTPAGP 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	37/98 (38%)
		DENN	98..282	CDD:280329	75/184 (41%)
		dDENN	315..379	CDD:129037	24/65 (37%)
DENND1A	XP_011517184.1	uDENN	24..106	CDD:214824	37/92 (40%)
		DENN	110..288	CDD:214823	76/182 (42%)
		dDENN	320..386	CDD:129037	24/65 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158330
Domainoid	1	1.000	137	1.000	Domainoid score	I4893
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm42234
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	O	PTHR13196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4852
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.770