Protein Alignment CG18659 and dennd1b

DIOPT Version :10

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_073793981.1
• Gene: dennd1b / 560720
• ZFINID: ZDB-GENE-060503-16
• Length: 774
• Species: Danio rerio
• Alignment Length: 707
• Identity: 230/707 - (32%)
• Similarity: 316/707 - (44%)
• Gaps: 102/707 - (14%)

  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |.|||..:..:.|:...:|. .|      ||.:..|.|     :..||:.|.|||||..:|.|.|
Zfish     1 MDSRINENPARTFDLALQVA-CP------SSENEDPTV-----LWKFPQDFGDQEVLQTVPKFCF 53

  Fly    66 PCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAE-L 125
            |.|....|.    |.::||.|..:||.||||||........:.|::||||.:.:.|||..||: |
Zfish    54 PFDVERVSPTQVGQNFTFVLTDIESKQRFGFCRLTSGCKLCICLLSYLPWFEIYYKLLNTLADYL 118

  Fly   126 RRTDPNGFRTFLSEAYNQGIPD---------------CGGSLKVYYSAGQSHFTFERPLQFQLPS 175
            .:...:.....|...:|..:|.               ..|.:..:..:.|.|..|..|....||:
Zfish   119 SKHQEDDLNDMLETLHNHPVPKPNTPVNLSVSNHLHFANGQVVQHPGSRQLHSYFVAPDINGLPT 183

  Fly   176 MPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPV 240
            :||:.||..|:..|:...|:.::|:||.|||||.||..|..|::|:..:.|.||||.||||||||
Zfish   184 IPESRNLTEYFVAVDVNNMLHLYASMLHERRIIITSSKLSTLTACVHGSTAMLYPMHWQHIFIPV 248

  Fly   241 LPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKK 305
            ||....||..||||||:||...:||.|.|..|.:|||||.||...|||.||:||||:::||.||.
Zfish   249 LPPHLLDYCCAPMPYLVGVHLSLLERVKSRSLEDVVILNVDTNTLESPTDDLHNLPSDVVSSLKS 313

  Fly   306 HLNHTHDHIGDRISKIFLNALVQLIGGYRDAVEYHENSK-TFNSQKFIESRPAHLRPFLAKMMDL 369
            .|.......|..:::.||:|...|.|.||||:.|..... ||..:.|:..|.:.:|.||...::|
Zfish   314 KLKKQSTATGAGVARAFLHAQAALFGSYRDALRYKPGEPITFCEKSFVAHRSSAMRGFLEMAVNL 378

  Fly   370 QIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEKKKRGRNYA--IMKNLKDKTNPAVKS---AVK 429
            |:|.|||:.||..||:|.||:|.:|.|.......|...::|.  |...::::..|.||:   |..
Zfish   379 QLFKQFIEGRLAKLNAGRGFTDVYEEEITEGGFCKSNSKSYQQWIHTKMRERAKPVVKNFQMAKD 443

  Fly   430 SVKEGSRGMKTAYKGFKTKLRENGNQFGGTHFHFGLGSPNHSDRPDGTSGGYVRGGKAIGAAHHS 494
            ..|...|.||.......|:..|               ||.....|..|.....|..:.|  |:.:
Zfish   444 HAKRKIRDMKDKITQKDTEEEE---------------SPYCEGSPTSTKSLSPRRLQRI--AYQN 491

  Fly   495 APSSPVT----SKRLDGIASVTGSSGSG----------GSGAREPREFLRRGPVPLAM----SSS 541
            ..|||.|    |...|..||...|..||          .|......|..:.|.:.|..    |.|
Zfish   492 LKSSPHTLYPDSYNNDDNASRISSEDSGEVPSYNEDSDESDLELRSEVSQSGQMNLLEEILDSLS 556

  Fly   542 SSHIQPNGHAYGASAGAHYG--HHLAASPAVSSASSLCSSSEMNLSQELQNHPL-FKTPAVD--- 600
            :|||: .|....|.:...:.  ..|..:|..|..|.||||......:.....|. :||...|
Zfish   557 TSHIE-QGRLSAAKSLDFFRSFEDLDYNPKKSFKSPLCSSPTATGCEVGNGEPAGWKTGQDDSAV 620

  Fly   601 --RSLKPNAEHRRGAAP-PARPPPPQSTPASYYNHPYAAHPHVESKPPRHT--STPT 652
              :.|.|:...:..:.. |..||||                 .|..|.|::  .|||
Zfish   621 HGKHLPPSPRRQTSSCSLPVHPPPP-----------------TEDIPMRNSLPETPT 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	32/88 (36%)
		DENN	98..282	CDD:460461	76/199 (38%)
		dDENN	315..379	CDD:129037	24/64 (38%)
dennd1b	XP_073793981.1	None