DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18659 and dennd1b

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_009294650.1	Gene:	dennd1b / 560720	ZFINID:	ZDB-GENE-060503-16	Length:	754	Species:	Danio rerio

Alignment Length:	692	Identity:	228/692 - (32%)
Similarity:	313/692 - (45%)	Gaps:	92/692 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |.|||..:..:.|:...:|. .|      ||.:..|.|     :..||:.|.|||||..:|.|.|
Zfish     1 MDSRINENPARTFDLALQVA-CP------SSENEDPTV-----LWKFPQDFGDQEVLQTVPKFCF 53

  Fly    66 PCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAE-L 125
            |.|....|.    |.::||.|..:||.||||||........:.|::||||.:.:.|||..||: |
Zfish    54 PFDVERVSPTQVGQNFTFVLTDIESKQRFGFCRLTSGCKLCICLLSYLPWFEIYYKLLNTLADYL 118

  Fly   126 RRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQLPSMPENHNLNLYYNFVE 190
            .:...:.....|...:|..:|.....:.:     ..|..|..|....||::||:.||..|:..|:
Zfish   119 SKHQEDDLNDMLETLHNHPVPKPNTPVNL-----SVHSYFVAPDINGLPTIPESRNLTEYFVAVD 178

  Fly   191 PKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFKDYLGAPMPY 255
            ...|:.::|:||.|||||.||..|..|::|:..:.|.||||.||||||||||....||..|||||
Zfish   179 VNNMLHLYASMLHERRIIITSSKLSTLTACVHGSTAMLYPMHWQHIFIPVLPPHLLDYCCAPMPY 243

  Fly   256 LIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKKHLNHTHDHIGDRISK 320
            |:||...:||.|.|..|.:|||||.||...|||.||:||||:::||.||..|.......|..:::
Zfish   244 LVGVHLSLLERVKSRSLEDVVILNVDTNTLESPTDDLHNLPSDVVSSLKSKLKKQSTATGAGVAR 308

  Fly   321 IFLNALVQLIGGYRDAVEYHENSK-TFNSQKFIESRPAHLRPFLAKMMDLQIFAQFIDDRLTMLN 384
            .||:|...|.|.||||:.|..... ||..:.|:..|.:.:|.||...::||:|.|||:.||..||
Zfish   309 AFLHAQAALFGSYRDALRYKPGEPITFCEKSFVAHRSSAMRGFLEMAVNLQLFKQFIEGRLAKLN 373

  Fly   385 SGLGFSDEFELETVRYAEKKKRGRNYA--IMKNLKDKTNPAVKS---AVKSVKEGSRGMKTAYKG 444
            :|.||:|.:|.|.......|...::|.  |...::::..|.||:   |....|...|.||.....
Zfish   374 AGRGFTDVYEEEITEGGFCKSNSKSYQQWIHTKMRERAKPVVKNFQMAKDHAKRKIRDMKDKITQ 438

  Fly   445 FKTKLRENGNQFGGTHFHFGLGSPNHSDRPDGTSGGYVRGGKAIGAAHHSAPSSPVT----SKRL 505
            ..|:..|               ||.....|..|.....|..:.|  |:.:..|||.|    |...
Zfish   439 KDTEEEE---------------SPYCEGSPTSTKSLSPRRLQRI--AYQNLKSSPHTLYPDSYNN 486

  Fly   506 DGIASVTGSSGSG----------GSGAREPREFLRRGPVPLAM----SSSSSHIQPNGHAYGASA 556
            |..||...|..||          .|......|..:.|.:.|..    |.|:|||: .|....|.:
Zfish   487 DDNASRISSEDSGEVPSYNEDSDESDLELRSEVSQSGQMNLLEEILDSLSTSHIE-QGRLSAAKS 550

  Fly   557 GAHYG--HHLAASPAVSSASSLCSSSEMNLSQELQNHPL-FKTPAVD-----RSLKPNAEHRRGA 613
            ...:.  ..|..:|..|..|.||||......:.....|. :||...|     :.|.|:...:..:
Zfish   551 LDFFRSFEDLDYNPKKSFKSPLCSSPTATGCEVGNGEPAGWKTGQDDSAVHGKHLPPSPRRQTSS 615

  Fly   614 AP-PARPPPPQSTPASYYNHPYAAHPHVESKPPRHT--STPT 652
            .. |..||||                 .|..|.|::  .|||
Zfish   616 CSLPVHPPPP-----------------TEDIPMRNSLPETPT 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	32/88 (36%)
		DENN	98..282	CDD:280329	74/184 (40%)
		dDENN	315..379	CDD:129037	24/64 (38%)
dennd1b	XP_009294650.1	uDENN	9..89	CDD:214824	33/91 (36%)
		DENN	94..271	CDD:214823	75/181 (41%)
		dDENN	305..368	CDD:129037	23/62 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5070
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm24251
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910