DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18659 and dennd1a

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_005161553.1	Gene:	dennd1a / 556150	ZFINID:	ZDB-GENE-060404-6	Length:	1007	Species:	Danio rerio

Alignment Length:	974	Identity:	289/974 - (29%)
Similarity:	402/974 - (41%)	Gaps:	190/974 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSRIKNDVKKLFEFWCEV----TPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIP 61
            ||||||......||.:.||    |...|||                :..|||:.:.:||.|..||
Zfish     1 MGSRIKESPGSAFEVYMEVVHSGTAGSGLE----------------VRRSFPDTYTEQETLQTIP 49

  Fly    62 SFAFPCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVL 122
            .|.||.:..|.:|    |.::||.|..|||.||||||.....::...:::||||.:.|.|||.:|
Zfish    50 KFCFPFNMDSMAVGQVGQNFTFVLTDIDSKQRFGFCRLSSGAHSCHCILSYLPWFEVFYKLLNIL 114

  Fly   123 AELRRTDPN-GFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQLPSMPENHNLNLYY 186
            |:......: .:|..|...:...|||.|  :.|:.|.   |..|..|...:|||:|||.||..|:
Zfish   115 ADYTTKGQDIQWRELLESLHVLNIPDPG--VPVHLSV---HLFFTVPDPRELPSIPENRNLTEYF 174

  Fly   187 NFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFKDYLGA 251
            ..|:...|:.::|:||.||||:.:...|..|::|:..|.|.||||.|||::|||||....||..|
Zfish   175 VAVDVNNMLHLYASMLYERRILISCSKLSTLTACVHGAAAMLYPMYWQHVYIPVLPQHLLDYCCA 239

  Fly   252 PMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKKHLNHTHDHIGD 316
            ||||||||...::|.|....|.:||:||.||...|:||||:.:||.::||.||..|.......||
Zfish   240 PMPYLIGVHSSLMEKVRGMALDDVVLLNVDTNTLETPFDDLQSLPNDVVSSLKNRLRKVSSSTGD 304

  Fly   317 RISKIFLNALVQLIGGYRDAVEYH-ENSKTFNSQKFIESRPAHLRPFLAKMMDLQIFAQFIDDRL 380
            .:::.||.|...|.|.||:|:... |...||:.:.||..|.:.:|.||...:.||.|.||||.||
Zfish   305 GVARAFLKAQAALFGSYRNALHIEPEEPITFSEETFITHRSSTMRQFLQNAIQLQFFKQFIDGRL 369

  Fly   381 TMLNSGLGFSDEFELETVRYAEKKKRGRNY------------AIMKNLKDKTNPAVKSAVKSVKE 433
            .:||||.||||:|| |.:...|.....:.|            ||:..:|.|.|||:|:..|..|:
Zfish   370 ELLNSGEGFSDQFE-EEINMGEYAGSDKTYHQWLFTVKKGSGAILNTVKTKANPAMKTVYKFAKD 433

  Fly   434 GSR-GMKTAYKGFKTK-LRENG-------NQFGGTH--------------FHFGLGSPNHSDRPD 475
            .:: |:|......|.| |.|||       .|...|.              .|||....:.|.||
Zfish   434 HAKMGIKEVKSRLKQKELTENGYSEEPGPTQLPSTQSKDSLTWDQRRPITVHFGQNERSPSPRP- 497

  Fly   476 GTSGGYVR--------GGKAIGAAHHSAPSSPVTSKRLDGIASVTGS------------------ 514
                  :|        ..|...:...:.|..|:.:||......|.||
Zfish   498 ------MRPQRPPPPHPSKLQRSIRPARPPRPLVAKRPRSNIGVEGSPEHYVRPTRHYTVFLCED 556

  Fly   515 ------SGSGGSGAREPREFLRRGPV----PLAMSSSSSHIQPNGHAYGASAGAHY-GHHLAASP 568
                  |....|.|..|..||...|.    |......:..::.     |...|..| |:...:||
Zfish   557 SSGDELSQDDDSIAAFPEHFLLSAPFEWPQPYRSLKEAELVEE-----GVEVGERYQGNTAPSSP 616

  Fly   569 AVSSASSLCSSSEMNLSQELQNHPLFKTPAVDRSLKP-NAEHRRGAAPPARP-----PPPQSTPA 627
            .:...|.|....:...:|  |..|  :.|.:..:.|| ::.|  .....||.     ..||:...
Zfish   617 VLDKFSDLSLLQDAFRNQ--QGKP--ECPEITNTTKPTHSTH--SILTSARSLEELRADPQNVNF 675

  Fly   628 SYYNHPYAAHPHVESKPPRHTSTP-----TRPRQP--LPTADSSSFDSPPDVQSPPI------PP 679
            :|......|.....:.|...|:.|     ::...|  |...:|.|::.|..|  ||:      ||
Zfish   676 NYQRMELNAGERTRTLPVLKTTNPYSKLWSQREDPSTLLGRESPSWERPLSV--PPLEPSDVRPP 738

  Fly   680 RRQGSSNAIVAATAAAVSAEISKLERNCWKDEPGN---------DSVRSSNASSSSATSSSSGAS 735
            .::.|::.......|.::....:..:.   .|||.         ..||  .|.......|:.|..
Zfish   739 SKESSNSCAEKTEGACITIPRPQGRKT---PEPGAVLAPAVTLLRGVR--QACDKEGGVSAGGQE 798

  Fly   736 FVTAASTFSHLNVSDPPIPTPRAKREQQQPLEDSMNDLISL--------DDSNNTSFDLEDFDPL 792
            |..|      ||:| |...|.....:..:|.|....||:||        .|....|.......|
Zfish   799 FRQA------LNMS-PQAQTQVDLLKTNEPNEGQEQDLLSLLDPLCGATKDEATPSLSKPPVPP- 855

  Fly   793 NQNARPLPPLSTAFAKKCSTLPAGVNSSVVASSVSNPLYPYFAPKHMATVAAVTGRTPP-MHPP 855
                ||.||....|....|..|          ....|.||  ..:|.:.|......||. |:||
Zfish   856 ----RPNPPNLANFPPPVSMNP----------FTQPPQYP--PQRHYSPVVPGNPFTPAFMNPP 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	33/92 (36%)
		DENN	98..282	CDD:280329	74/184 (40%)
		dDENN	315..379	CDD:129037	26/64 (41%)
dennd1a	XP_005161553.1	uDENN	9..89	CDD:214824	34/95 (36%)
		DENN	93..271	CDD:214823	75/182 (41%)
		dDENN	303..368	CDD:129037	26/64 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594245
Domainoid	1	1.000	132	1.000	Domainoid score	I5070
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm24251
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	O	PTHR13196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4852
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870