DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18659 and Dennd1c

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_038939863.1	Gene:	Dennd1c / 363326	RGDID:	1590869	Length:	786	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	236/815 - (28%)
Similarity:	353/815 - (43%)	Gaps:	169/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |||........:|:::.|......||...            :|:..||..|::||.:..:|.|.|
  Rat     1 MGSTEIRHPSAVFDWFFEAGRPNSLEEDP------------LILRKFPPDFQEQEAMQMVPRFCF 53

  Fly    66 PCD----TTSTSVQTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLL----PVL 122
            |.|    ..|.:||.::|..|......||||||......:.:.::::|||.:.|.|:|    .:|
  Rat    54 PFDIEREPPSPAVQHFTFALTDLVGNRRFGFCRLRAGAWSCLCILSHLPWFEVFYKILNTVGDLL 118

  Fly   123 AELRRTDPNGF------RTFLSEAYNQGIPDCGGSLKVYYSAG---------QSHFTFERPLQFQ 172
            |:.:.|:....      ..:|...::.| |....|:..:...|         :....|..|....
  Rat   119 AQNQVTEAEELLQNLQQHPYLGPGFSGG-PKTDSSITSWSECGILPPALGNSKLLSCFVAPDAAG 182

  Fly   173 LPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIF 237
            |||:|||.||......|..:.::.:|||:|||||::.|:..|..|::|:.|:.|.||||.|:|:.
  Rat   183 LPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVL 247

  Fly   238 IPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQ 302
            ||.||....||..|||||||||...:.|.|....|.:||:||.|:...|:|||||..||.::||.
  Rat   248 IPTLPPHLLDYCCAPMPYLIGVHSSLAERVREKALEDVVVLNADSNTLETPFDDVQALPPDVVSL 312

  Fly   303 LKKHLNHTHDHIGDRISKIFLNALVQLIGGYRDA-VEYHENSKTFNSQKFIESRP-AHLRPFLAK 365
            |:..|.......|:.:|::||.|...|.|||||| |.......||:.:.|:..:| |.|:.|..|
  Rat   313 LRLRLRKVALSPGEGVSRLFLKAQALLFGGYRDALVCIPGQPVTFSEEAFLAQKPGAPLQAFHKK 377

  Fly   366 MMDLQIFAQFIDDRLTMLNSGLGFSDEFELE----------TVR----YAEKKKRGRNYAIMKNL 416
            .:.||:|.|||:.||..||:|.||||:||.|          |:|    :|:..|:|.: |::.::
  Rat   378 AVHLQLFKQFIESRLEKLNAGEGFSDQFEQEIIACCGASSGTLRSYQLWADSLKKGSD-ALLHSV 441

  Fly   417 KDKTNPAVKSAVKSVKEGSRGMKTAYKGFKTKLRENGN---QFGGTHFHFGLGSPNHSDRPDGTS 478
            |.||.|||::..:|.|.|.:||:...      :.::|:   |.||:     |.:|:.:.|.|
  Rat   442 KAKTRPAVRNMYRSAKSGLKGMQNLL------MIKDGDSCLQRGGS-----LRTPSLTSRSD--- 492

  Fly   479 GGYVRGGKAIGAAHHSAPSSPV-TSKRL--DGIASVTGSSGSGGSGAREPREFLRRGPV------ 534
                |..:.:..:.|...:.|: .|:||  :|             |..||.:  .|.|.
  Rat   493 ----RLQQRLPISQHFGQNRPLRPSRRLKPEG-------------GPSEPLQ--ERSPTLNSRDT 538

  Fly   535 --PLAMSSSSSHIQPNGHAY--------GASAGAHYGHHLAASPAV----SSASSLCSSSEMNLS 585
              |.|..:.......:|...        ..|.....|..|.||.::    ..||..|||
  Rat   539 QNPWAEDTLDGSFLGSGEELDLLSEILDSLSVEIKSGGQLRASQSLDCCQQGASESCSS------ 597

  Fly   586 QELQNHPLFKTPAVDRSLKPNAEHRRGAAP-----PARPPPPQSTP----ASYYNHPYAAHPHVE 641
              |.:.|:.....::       |.||...|     |....|.|.||    .||..:.......:.
  Rat   598 --LPDIPVGSPWQLE-------EDRRSQDPQLQSLPGDLSPLQDTPFSEVVSYSKNCPQPPSDIS 653

  Fly   642 SKPPRHTSTPTRPRQPLPTADSSSFDSPPDVQSP----------PIPPRRQGSSNAIVAATAAAV 696
            |.|....::...|.|..|...|||...|...|||          |.||:.|     ::|:|
  Rat   654 SLPTSSATSADPPSQRDPGPSSSSKLDPTPSQSPCSRTLRVPTQPTPPKSQ-----LLAST---- 709

  Fly   697 SAEISKLERNCWKDEPGNDSVRSSNASSSSATSSS 731
                          ||.:|:|:......|...|.|
  Rat   710 --------------EPNSDTVQKLQPIQSPLCSQS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	25/88 (28%)
		DENN	98..282	CDD:280329	67/202 (33%)
		dDENN	315..379	CDD:129037	27/65 (42%)
Dennd1c	XP_038939863.1	uDENN	9..87	CDD:214824	25/89 (28%)
		DENN	93..293	CDD:214823	68/200 (34%)
		dDENN	325..391	CDD:129037	27/65 (42%)
		Atrophin-1	596..>775	CDD:397323	40/173 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4788
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm46387
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	LDO	PTHR13196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.910