DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18659 and Dennd1b

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_006529779.1	Gene:	Dennd1b / 329260	MGIID:	2447812	Length:	786	Species:	Mus musculus

Alignment Length:	875	Identity:	246/875 - (28%)
Similarity:	356/875 - (40%)	Gaps:	211/875 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |..|.:.:.::.|:...:|       :..:|.:..|.|     :..|||.|.|||||..:|.|.|
Mouse     1 MDRRTRENPERTFDLVLKV-------KCHASENEDPEV-----LWKFPEDFGDQEVLQSVPKFCF 53

  Fly    66 PCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAE-L 125
            |.|....|.    |.::||.|..:||.||||||........:.:::||||.:.:.|||..||: |
Mouse    54 PFDVERVSQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRICLCILSYLPWFEVYYKLLNTLADYL 118

  Fly   126 RRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQS-----------------HFTFERPLQFQL 173
            .:.........|...||..:|.  .:..|..|..|.                 |..|..|....|
Mouse   119 AKELEEDLNETLKSLYNHPVPK--ANTPVNLSVNQELFIASEQVLKDDPSLIPHSCFITPDITGL 181

  Fly   174 PSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFI 238
            |::||:.||..|:..|:...|:.::|:||.|||||.||..|..|::|:..:.|.||||.||||:|
Mouse   182 PTIPESRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYI 246

  Fly   239 PVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQL 303
            ||||....||..||||||||:...::|.|.:..|.:||:||.||...||||:|:.:||:::||.|
Mouse   247 PVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVVLNVDTNTLESPFNDLSSLPSDVVSAL 311

  Fly   304 KKHLNHTHDHIGDRISKIFLNALVQLIGGYRDAVEYHENSK-TFNSQKFIESRPAHLRPFLAKMM 367
            |..|.......||.:::.||.|...|.|.||||:.|..... ||..:.|::.|.:.::.||...:
Mouse   312 KNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAV 376

  Fly   368 DLQIFAQFIDDRLTMLNSGLGFSDEFELETVR---------------YAEKKKRGRNYAIMKNLK 417
            :||:|.||||.||..||:|.||||.||.|...               |..||    ..|:.....
Mouse   377 NLQLFKQFIDGRLAKLNAGRGFSDIFEEEITSGGFCGGSPRSYQQWVYTVKK----GGALFNTAV 437

  Fly   418 DKTNPAVKSAVKSVKEGSR-GMKTAYKGFKTKLRENGNQFGGTH----------FHFGLG----- 466
            .|..|||::|.|..|..:| |:|......|.|  :|..::|...          .|...|
Mouse   438 TKATPAVRTAYKFAKSHARLGLKEVKSRLKHK--DNEEEYGTCSGLVQYTPVYTLHNEKGENREK 500

  Fly   467 ---SPNHSDRP----DGT------------------------SGGYVRGGKAIGAAHHSAPSS-- 498
               |..|..||    |||                        :..|.........|...||.|
Mouse   501 HKLSQTHLKRPHKSLDGTLYDDDDDDDDIERASKISSEDGEETRAYFYESDDSVEAQVKAPYSGE 565

  Fly   499 -PVTSKRLDGIASVTGSSGSGGSGAREPREFLRRGPVPLAMSSSSSHIQPNGHAYGASAGAHYGH 562
             .:..:.||.::  |.||..|.....:..:|.|        |......:|.
Mouse   566 MDLLGEILDTLS--THSSDQGKLAPAKSLDFFR--------SMDDIDYKPT-------------- 606

  Fly   563 HLAASPAVSSASSLCSS---SEMNLSQELQNHPLFKTPAVDRSLKPNAEHRRGAAPPARPPPPQS 624
            :.:.:|:.::.:.||:|   .|.||.|:                 .:|.|.|     ..||.|:.
Mouse   607 NKSNAPSENNLALLCASGDQGEWNLGQD-----------------DSALHGR-----QLPPSPRK 649

  Fly   625 TPAS--YYNHPYAAHPHVESKP--PRHTSTPTRPRQPLPTADSSSFDSPPDVQSPPIPPRRQGSS 685
            ..:|  .....:........||  ....|.||...:|.||:         .::|.|..|
Mouse   650 RVSSGGLTESLFILKEESREKPLCADSVSGPTVVGKPAPTS---------GLRSQPAAP------ 699

  Fly   686 NAIVAATAAAVSAEISKLERNC--WKDEPGNDSVRSSNASSSSATSSSSGASFVTAASTFSHLNV 748
                         |.|:.||..  .|..||...::|.:.|.....|..         |||
Mouse   700 -------------EASQTERGRAEVKQTPGQAPLQSEDLSVPGPGSRQ---------STF----- 737

  Fly   749 SDPPIPTPRAKREQQQPLED--SMNDLISL 776
                :|..:|.:|..:|.:|  .:.:::||
Mouse   738 ----VPWEKAGKEDTKPSKDVGLLQEVVSL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	31/88 (35%)
		DENN	98..282	CDD:280329	73/201 (36%)
		dDENN	315..379	CDD:129037	25/64 (39%)
Dennd1b	XP_006529779.1	uDENN	9..89	CDD:214824	32/91 (35%)
		DENN	92..291	CDD:214823	74/200 (37%)
		dDENN	323..388	CDD:129037	25/64 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848724
Domainoid	1	1.000	136	1.000	Domainoid score	I4893
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm44288
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	O	PTHR13196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4852
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770