DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18659 and Dennd2b

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_038934122.1	Gene:	Dennd2b / 308944	RGDID:	1308995	Length:	1153	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	126/474 - (26%)
Similarity:	200/474 - (42%)	Gaps:	83/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRD-------QEVLTGIPSFAFP- 66
            ::|||::..|:    |::..|..:..|.|.     ..||:..|.       :|.|..||.|.||
  Rat   691 RELFEYFVVVS----LKKKPSRNTYLPEVS-----YQFPKLDRPTKQMREAEERLKAIPQFCFPD 746

  Fly    67 ----CDTTSTSVQTYSFVHTTGDSKWRFGFCR------QDPRTNTAMVLITYLPWHDTFLK---- 117
                ...:..|.:|:||:.|..|...|||:||      :.||......:|:.|.....|.|
  Rat   747 AKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPNGKGPRLPEVYCVISRLGCFGLFSKEVEK 811

  Fly   118 ----LLP--------VLAELRRTDPNGFRT-----FLSEAYNQGIPDCGGSLKV---YYSAGQSH 162
                |.|        ||.|:.|.  .|...     |:........|..|.::||   ...||...
  Rat   812 ALPTLFPLGCWWCAQVLDEVERR--RGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEV 874

  Fly   163 FTFERPLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAF 227
            ....||:..:|    |:.:....:..:..:::|.:||::|.|||:||.:..|..||||..|..|.
  Rat   875 LELRRPMDSRL----EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVAL 935

  Fly   228 LYPMVWQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDV 292
            |||..|||.||||||....|.:..|.|:|:|:....|..:....:.|.:::|..:..|....||.
  Rat   936 LYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDE 1000

  Fly   293 HN-LPTEIVSQLKKHLNHTHDHIGD---------------RISKIFLNALVQLIGGYRDAVEYHE 341
            .. ||.::.:.|::.|...::.|..               .:|::|:...|:.:|.|...:.:.|
  Rat  1001 DTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTHSE 1065

  Fly   342 -NSKTFNSQKFIES-RPAHLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEK- 403
             ..:.|..:.|.:| ....:|.||...|:.|:||.||.||........|.   ||....:|.|:
  Rat  1066 KGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL---FEQRVEQYLEEL 1127

  Fly   404 ---KKRGRNYAIMKNLKDK 419
               ::.|.| ..::.|.:|
  Rat  1128 PDTEQSGMN-KFLRGLGNK 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	29/102 (28%)
		DENN	98..282	CDD:280329	59/207 (29%)
		dDENN	315..379	CDD:129037	18/80 (23%)
Dennd2b	XP_038934122.1	uDENN	694..781	CDD:214824	28/95 (29%)
		DENN	788..988	CDD:396629	58/205 (28%)
		dDENN	1039..1105	CDD:129037	18/65 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910