DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18659 and DENND2A

DIOPT Version :10

Sequence 1:NP_665880.2 Gene:CG18659 / 35929 FlyBaseID:FBgn0027561 Length:908 Species:Drosophila melanogaster
Sequence 2:NP_056504.3 Gene:DENND2A / 27147 HGNCID:22212 Length:1009 Species:Homo sapiens


Alignment Length:463 Identity:119/463 - (25%)
Similarity:197/463 - (42%) Gaps:64/463 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 IKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFP----EGFR----DQEVLTGIP 61
            |:...::|||::..|:    |.:   .::|...||.  :.:.||    ..|:    .::.|..||
Human   557 IEYQERQLFEYFVVVS----LHK---KQAGAAYVPE--LTQQFPLKLERSFKFMREAEDQLKAIP 612

  Fly    62 SFAFPCDTTSTSVQ-----TYSFVHTTGDSKWRFGFCR------QDPRTNTAMVLITYLPWHDTF 115
            .|.||.......||     |:|||.|..|...|||:||      :..|......:::.|.....|
Human   613 QFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLF 677

  Fly   116 LKLLPVLAELRRTDPNGFRTFLSEAYNQGIPDCGGSLKV-YYSAGQSHFTFE--RPLQFQLPSMP 177
            .::|..:.:.|...|...:..:........|..|.::.| .:..|......|  |||..:|    
Human   678 SRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL---- 738

  Fly   178 ENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLP 242
            |:.:....::.:..:.::.|||::|.|||:||.:..|..||.|..|..|.:||..|||.:|||||
Human   739 EHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLP 803

  Fly   243 WEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHN-LPTEIVSQLKKH 306
            ....|.:.:|.|:|||:....|..:....|.||::::.....|....||..: ||.::...|:..
Human   804 PAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHI 868

  Fly   307 LNHTHD-------------H------IGDRISKIFLNALVQLIGGYRDAVEYHE-NSKTFNSQKF 351
            |...::             |      :.:.:|:.|:...|:::|.|...:...| ..:|...:.|
Human   869 LEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAF 933

  Fly   352 ---IESRPAHLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEKKKRGRNYAIM 413
               :.|:  .||.||...|:.|:|..||.:|........|.   ||:....|.|....|.:..:.
Human   934 RKAVSSK--SLRHFLEVFMETQMFRGFIQERELRRQDAKGL---FEVRAQEYLETLPSGEHSGVN 993

  Fly   414 KNLKDKTN 421
            |.||...|
Human   994 KFLKGLGN 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18659NP_665880.2 uDENN 10..95 CDD:214824 30/103 (29%)
DENN 98..282 CDD:460461 51/186 (27%)
dDENN 315..379 CDD:129037 18/67 (27%)
DENND2ANP_056504.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..153
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..334
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..479
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..532
uDENN 561..653 CDD:214824 30/100 (30%)
DENN 660..816 CDD:460461 43/159 (27%)
dDENN 896..962 CDD:129037 18/67 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.