DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18659 and DENND2A

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	NP_001304981.1	Gene:	DENND2A / 27147	HGNCID:	22212	Length:	1009	Species:	Homo sapiens

Alignment Length:	463	Identity:	119/463 - (25%)
Similarity:	197/463 - (42%)	Gaps:	64/463 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFP----EGFR----DQEVLTGIP 61
            |:...::|||::..|:    |.:   .::|...||.  :.:.||    ..|:    .::.|..||
Human   557 IEYQERQLFEYFVVVS----LHK---KQAGAAYVPE--LTQQFPLKLERSFKFMREAEDQLKAIP 612

  Fly    62 SFAFPCDTTSTSVQ-----TYSFVHTTGDSKWRFGFCR------QDPRTNTAMVLITYLPWHDTF 115
            .|.||.......||     |:|||.|..|...|||:||      :..|......:::.|.....|
Human   613 QFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLF 677

  Fly   116 LKLLPVLAELRRTDPNGFRTFLSEAYNQGIPDCGGSLKV-YYSAGQSHFTFE--RPLQFQLPSMP 177
            .::|..:.:.|...|...:..:........|..|.::.| .:..|......|  |||..:|
Human   678 SRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL---- 738

  Fly   178 ENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLP 242
            |:.:....::.:..:.::.|||::|.|||:||.:..|..||.|..|..|.:||..|||.:|||||
Human   739 EHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLP 803

  Fly   243 WEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHN-LPTEIVSQLKKH 306
            ....|.:.:|.|:|||:....|..:....|.||::::.....|....||..: ||.::...|:..
Human   804 PAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHI 868

  Fly   307 LNHTHD-------------H------IGDRISKIFLNALVQLIGGYRDAVEYHE-NSKTFNSQKF 351
            |...::             |      :.:.:|:.|:...|:::|.|...:...| ..:|...:.|
Human   869 LEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAF 933

  Fly   352 ---IESRPAHLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEKKKRGRNYAIM 413
               :.|:  .||.||...|:.|:|..||.:|........|.   ||:....|.|....|.:..:.
Human   934 RKAVSSK--SLRHFLEVFMETQMFRGFIQERELRRQDAKGL---FEVRAQEYLETLPSGEHSGVN 993

  Fly   414 KNLKDKTN 421
            |.||...|
Human   994 KFLKGLGN 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	30/103 (29%)
		DENN	98..282	CDD:280329	51/186 (27%)
		dDENN	315..379	CDD:129037	18/67 (27%)
DENND2A	NP_001304981.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..532
		uDENN	561..653	CDD:214824	30/100 (30%)
		DENN	660..816	CDD:307995	43/159 (27%)
		dDENN	896..962	CDD:129037	18/67 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810