Protein Alignment CG18659 and Dennd1a

DIOPT Version :9

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_006498061.1
• Gene: Dennd1a / 227801
• MGIID: 2442794
• Length: 1078
• Species: Mus musculus
• Alignment Length: 1156
• Identity: 307/1156 - (26%)
• Similarity: 427/1156 - (36%)
• Gaps: 326/1156 - (28%)

  Fly     1 MGSRIKNDVKKLFEFWCEVT-PTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFA 64
            ||||||.:.:..||.:.||. |..|   ||.|   .|.|.     ..|||.:.|||||..:..|.
Mouse     1 MGSRIKQNPETTFEVYVEVAYPRTG---GTLS---DPEVQ-----RQFPEDYSDQEVLQTLTKFC 54

  Fly    65 FPCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAE- 124
            ||....|.:|    |.::||.|..|||.||||||......:...:::||||.:.|.|||.:||:
Mouse    55 FPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADY 119

  Fly   125 LRRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQLPSMPENHNLNLYYNFV 189
            ..:...:.:...|...:...|||.|  :.|:.|. .|:||.  |...:|||:|||.||..|:..|
Mouse   120 TTKRQESQWNELLETLHRLPIPDPG--VSVHLSV-HSYFTV--PDSRELPSIPENRNLTEYFVAV 179

  Fly   190 EPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFKDYLGAPMP 254
            :...|:.::|:||.||||:.....|..|::||..:.|.||||.|||::|||||....||..||||
Mouse   180 DVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMP 244

  Fly   255 YLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQLKKHLNHTHDHIGDRIS 319
            ||||:...::|.|.:..|.:|||||.||...|:||||:.:||.:::|.||..|.......||.::
Mouse   245 YLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVA 309

  Fly   320 KIFLNALVQLIGGYRDAVEYH-ENSKTFNSQKFIES-RPAHLRPFLAKMMDLQIFAQFIDDRLTM 382
            :.||.|.....|.||:|::.. |...||:.:.|:.. |...::.||.....||:|.||||.||.:
Mouse   310 RAFLKAQAAFFGSYRNALKIEPEEPITFSEEAFVSHYRSGAMKQFLQNATQLQLFKQFIDGRLDL 374

  Fly   383 LNSGLGFSDEF--ELETVRYAEKKK---------RGRNYAIMKNLKDKTNPAVKSAVKSVKEGSR 436
            ||||.||||.|  |:....||...|         |..:.||:..:|.|.|||:|:..|..|:.::
Mouse   375 LNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAK 439

  Fly   437 -GMKTAYKGFKTK-LRENGNQFGGTH--------------------------FHFGLGSPNHSDR 473
             |:|......|.| :.|||.......                          .|||.....|..|
Mouse   440 MGIKEVKNRLKQKDITENGCVSSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQQQRLHPTR 504

  Fly   474 PDGTSGGYVRGGKAIGAAHHSAPSSPVTSKRLDGIASVTGSSGSGGSGAREPREFLRRGPVPLAM 538
            |                     |...:...|                ..|.||..:.|.|
Mouse   505 P---------------------PPPKIQRSR----------------PVRPPRPHVVRRP----- 527

  Fly   539 SSSSSHIQPNGHAYGASAGAHYG---HHLAASPAVSSASSLCSSSE---MNLSQELQNHPLFKTP 597
               .|:|...|.....|:..|..   .|.|...:..|:...|...|   ...::.|.....|:.|
Mouse   528 ---KSNITVEGRRTSVSSPEHLVKPLRHYAVFLSEDSSDEECRREEAPSTGFTESLLFSAPFEWP 589

  Fly   598 AVDRSLK--PNAEHRRGAAP---------PARPPPPQS--------------------------- 624
            ...|:||  .:||.....:|         |...||.::
Mouse   590 QPYRTLKESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLEDVFSSLDVEAPLQPLGQAKS 654

  Fly   625 -----TPASYYNHPYA-----------------------AHPH------------VESKP----P 645
                 .|......|.:                       |||:            :.|||    |
Mouse   655 LEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPYTKLWSLGQDDMAIPSKPSITSP 719

  Fly   646 RHTST--PTRPRQPLPTADSSSFDSPPDVQSPPIP-------PRRQGSSNAIVAATAAAVSAEIS 701
            ...|.  .|.|..||...:.....||...:..|||       ||.||.....:.......:|..:
Mouse   720 EKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPA 784

  Fly   702 KLER-----NCWKDEPGNDSVRSSNASSSSATSSSSGASFVTAASTFSHLNVSDPPIPTPRAKRE 761
            ||:.     ..:..|| ....|...|:.|.|..|......|....|    .:..||.|.|.|
Mouse   785 KLQAAGGPLGDFSSEP-LQMDRERQAALSPALLSGLLPRAVPQGPT----ELLQPPSPAPGA--- 841

  Fly   762 QQQPLEDSMNDLISLDDSNNTSFD------------------------------------LEDFD 790
                .....:.|::|.|..||::.                                    |..|.
Mouse   842 ----AGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFV 902

  Fly   791 PLNQNARPLPPLSTAFAKKCSTLPAGVN----SSVVASSV------------------------- 826
            |......|..|||:..|:...|.||.:.    .|::.||.
Mouse   903 PSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIP 967

  Fly   827 ----SNPLYPY----FAPKHMAT----------------VAAVTGRTP--PMHPPPQIQ---RNT 862
                ::||.|.    .||..:.|                :|...|.:|  |..||..:|   :.:
Mouse   968 MGAHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPS 1032

  Fly   863 IAAKPDDDFE-LLRKYGLD----QFTLNANGTEKSQQLTTGKGMNNWTTFD 908
            :..:..|.|| ||||...|    .....|..:...:||     ...|.||:
Mouse  1033 VPTQARDPFEDLLRKTKQDVSPSPAPALAPASTSVEQL-----RRQWETFE 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	36/89 (40%)
		DENN	98..282	CDD:280329	74/184 (40%)
		dDENN	315..379	CDD:129037	23/65 (35%)
Dennd1a	XP_006498061.1	uDENN	9..91	CDD:214824	37/92 (40%)
		DENN	95..273	CDD:214823	75/182 (41%)
		dDENN	305..371	CDD:129037	23/65 (35%)
		PHA03247	<711..1037	CDD:223021	67/337 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848726
Domainoid	1	1.000	136	1.000	Domainoid score	I4893
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm44288
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	O	PTHR13196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4852
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770