DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18659 and dennd1c

DIOPT Version :9

Sequence 1:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster
Sequence 2:	XP_005168459.1	Gene:	dennd1c / 101886409	ZFINID:	ZDB-GENE-090313-329	Length:	864	Species:	Danio rerio

Alignment Length:	885	Identity:	238/885 - (26%)
Similarity:	359/885 - (40%)	Gaps:	142/885 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSRIKNDVKKLFEFW-----CEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGI 60
            ||||||.:..|.| :|     |.:           :|...|.|     :..|||.|.|:|....:
Zfish     1 MGSRIKKNPDKTF-YWFFQASCPI-----------ARDKDPDV-----LFQFPEDFNDEESRKSL 48

  Fly    61 PSFAFPCD----TTSTSVQTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPV 121
            |.|.||.|    ..|.:||.::||.|..:...||||||....:.|.:.:::||||.:.|.|||..
Zfish    49 PRFCFPYDIERVKDSVAVQHFTFVLTDLEGCQRFGFCRLTSSSQTCLCILSYLPWFEVFYKLLNN 113

  Fly   122 LAEL-RRTDPNGFRTFLSEAYNQGIPDCGGSL----------------------KVYYSAGQSHF 163
            |||. .:...|.....||..|...:|...||:                      |...|||..:|
Zfish   114 LAECSSKGQTNEMTELLSALYKHPVPPANGSITLQMGAKLMIGSEMPGICGHAPKGEESAGIPYF 178

  Fly   164 TFERPLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFL 228
            ....|.  .|||:||:.||......|:...::.::|:||.||||:.....|..|::|:.|.|..|
Zfish   179 IAPDPK--ALPSIPESRNLTELVVAVDVGNLLQLYASMLFERRILIYCSKLSTLTACVHACNGML 241

  Fly   229 YPMVWQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVH 293
            :||.||||||||||....||..||||||||:...:.|.|.|..|.:|||||.||...|||.:|:.
Zfish   242 FPMYWQHIFIPVLPPHLLDYCCAPMPYLIGIHSSLAERVKSRALEDVVILNIDTNTLESPHEDLK 306

  Fly   294 NLPTEIVSQLKKHLNHTHDHIGDRISKIFLNALVQLIGGYRDAVEY-HENSKTFNSQKFIESRPA 357
            .:|.::|:.||..|.......|..::..||.|...|.||||||::. .:....|.::.|:..:..
Zfish   307 KIPADVVAGLKVRLKRQAAAAGSGVAHAFLRAQALLFGGYRDALQAPADGPVVFCTELFLNHKSP 371

  Fly   358 HLRPFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRYAEKKKRGRNYAIMKNLKDKTNP 422
            .:|.||...:.||.|.:|||.||.|||.|...||.||.|.::........:
Zfish   372 SMREFLESAVHLQCFKEFIDGRLEMLNEGKEPSDVFEEELLQCGASSGGAK-------------- 422

  Fly   423 AVKSAVKSVKEGSRGMKTAYKGFKTKLRENGNQFGGTHFHFGLGSPN---HSDRPDGTSGGYVRG 484
            ..:..|.::|:|...:...:|....|         .|.:|...|..|   ..|:|:..:  ..||
Zfish   423 LCRQWVGNLKKGGGALIVTWKSTANK---------ATKYHSKFGLKNLLSSKDQPEACT--LQRG 476

  Fly   485 GKAIGAAHHSAPSSPVTSKRLDGIASVTGSSGSGGSGAREPREFLRRGPVPLAMSSSSSHIQPNG 549
            |.......:....|.....||. |....|.|.......:..|:..::.||             |.
Zfish   477 GSVCEPHTYRLIQSDCLQNRLP-ITQHFGKSRPRRPAQKHHRQKEQKTPV-------------NN 527

  Fly   550 HAYGASAGAHYGHHLAASPAVSSA-----SSLCSSSEMNLSQELQNHPLFKTPAVDRSLKPNAEH 609
            ..|..|| |......:.|..|...     |.|..:.||:|..|     :|.|.:...|.:|...:
Zfish   528 TTYEDSA-ADAVDQCSGSSDVQEEEEEDFSLLADAEEMDLLGE-----IFDTLSAQSSREPGLLY 586

  Fly   610 RRGAAPPARPPPPQSTPASYYNHPYAAHPHVESKPPRHTSTPTRPRQPLPTADSSSFDSPPDVQS 674
            ...:....|     |..:.:.:|...|:|..||..|...::.:     |.:.:....:.|.....
Zfish   587 GTRSLDLFR-----SDSSEFISHKGLANPSQESLSPSFANSGS-----LMSWEEELEEGPDGEGE 641

  Fly   675 PPIPPRRQGSSN-----------AIVAATAAAVSAEISKLERNCWKDEPGNDSVRS-----SNAS 723
            .|.....:|:.|           :|:....:  ..|:::||::.  .|.| :::||     .:||
Zfish   642 GPGGGEEEGTVNEEKGTFNEEEESIIMIDGS--ENELNELEKDL--TELG-ETLRSDLQDLEDAS 701

  Fly   724 SSSATSSSSGASFVTAASTFSHLNVSDPPIPTPRAKREQQQPLEDSMNDLISLDDSNNTSFDLED 788
            ..|:..........|..:.....::....|...|.:.:..:..|:..|:   ..|::|.....|.
Zfish   702 VESSQEVQENTQDYTQMNGTMEESLDTETIAEERTETQTDKEEEELQNE---TPDASNGHTHEES 763

  Fly   789 FD---PLNQNARPLPPLSTAFAKKCSTLPAGVNSSVVASS 825
            ..   .::|...|....:.|...|.|:..|...|.|:..|
Zfish   764 ISLKVKIDQREEPEEKSAEAQLPKVSSTVALFQSKVLVDS 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	29/93 (31%)
		DENN	98..282	CDD:280329	77/206 (37%)
		dDENN	315..379	CDD:129037	22/64 (34%)
dennd1c	XP_005168459.1	uDENN	9..89	CDD:214824	30/96 (31%)
		DENN	93..296	CDD:214823	78/204 (38%)
		dDENN	328..393	CDD:129037	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594244
Domainoid	1	1.000	132	1.000	Domainoid score	I5070
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001916
OrthoInspector	1	1.000	-	-		otm24251
orthoMCL	1	0.900	-	-		OOG6_103678
Panther	1	1.100	-	-	LDO	PTHR13196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.740