Protein Alignment CG18659 and dennd1b

DIOPT Version :10

• Sequence 1: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: XP_012817957.1
• Gene: dennd1b / 101735275
• XenbaseID: XB-GENE-981228
• Length: 730
• Species: Xenopus tropicalis
• Alignment Length: 711
• Identity: 216/711 - (30%)
• Similarity: 307/711 - (43%)
• Gaps: 133/711 - (18%)

  Fly     1 MGSRIKNDVKKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFPEGFRDQEVLTGIPSFAF 65
            |.||.:...::.|:...:|       ...||.:..|     |::..|||.|.||::|..:|.|.|
 Frog     1 MDSRTREKPERTFDLVIKV-------ECPSSENEDP-----VLLWKFPEDFSDQDLLCMVPKFCF 53

  Fly    66 PCD----TTSTSVQTYSFVHTTGDSKWRFGFCRQDPRTNTAMVLITYLPWHDTFLKLLPVLAE-L 125
            |..    |.|...|.::||.|..:||.||||||........:.:::||||.:.:.|||..||: |
 Frog    54 PFAIERVTQSQIGQHFTFVLTDIESKQRFGFCRLTSGGKICLCILSYLPWFEIYYKLLNTLADYL 118

  Fly   126 RRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFERPLQFQ-----------------L 173
            .:...|.....|...||..:|:  ....|..|..|..|....|...:                 |
 Frog   119 VKEQENDLNDMLKSWYNHPVPE--AHTPVSLSLNQQLFISSEPALIKQPSPLLHSYFITPDVTGL 181

  Fly   174 PSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFI 238
            |::||:.||..|:..|:...|:.::|:||.|||||||||.|..|::|:.|:.:.||||.||||:|
 Frog   182 PTIPESRNLTEYFVAVDVNNMLQIYASMLHERRIIFTSRKLSTLTACVHASASLLYPMYWQHIYI 246

  Fly   239 PVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPTEIVSQL 303
            ||||....||..|||||||||...::|.|.|..|.:|||||.|....|:||:|:..||:::|:.|
 Frog   247 PVLPPHLLDYCCAPMPYLIGVHLSLMERVKSRSLDDVVILNVDNNSLETPFNDLCLLPSDVVATL 311

  Fly   304 KKHLNHTHDHIGDRISKIFLNALVQLIGGYRDAVEYHENSK-TFNSQKFIESRPAHLRPFLAKMM 367
            |..|.......||.:|:.||.|...|.|.||||:.|..... ||..:.|:..|...::.||...:
 Frog   312 KSKLKKQSTSTGDGVSRAFLRAQASLFGSYRDALRYKPGEPVTFCEESFVCHRSNTMKLFLETAV 376

  Fly   368 DLQIFAQFIDDRLTMLNSGLGFSDEFELETV--------RYAEKKKRGR---NYAIMKNLKDKTN 421
            :||:|.||||.||..||||.||:|.||.|..        ::....|:|.   |.|::     |.:
 Frog   377 NLQLFKQFIDSRLEKLNSGRGFTDLFEEEITSGNSSSYQQWVHTMKKGGSLINTAVI-----KAS 436

  Fly   422 PAVKSAVKSVKEGSRGMKTAYKGFKTKLRE---------------NGNQFGGTHFHFGLGS---- 467
            ||:|||.|..|..:   |...|..|:||:.               :.|.|...|.|...|.
 Frog   437 PAMKSAYKFAKNQA---KQGIKEVKSKLKHKDIEEEDSEYNLQCTHSNTFPLNHSHRQSGQRRKL 498

  Fly   468 ------------PNHS------DRPDGTS----------GGYVRGGKA----IGAAHHSAPSSPV 500
                        .|||      |..|..|          .||......    :..:........:
 Frog   499 SQTRTNRPLTHLGNHSSVQEDADLGDSASKLSSEDSEEASGYFDDSDTSYDDVSLSSRPGGEMDL 563

  Fly   501 TSKRLDGIASVTGSSGSGGSGAREPREFLR------------------RGPVPLAMSSSSSHIQP 547
            ..:.||.:::.:...|:|...|.:..:|.|                  ..|.|:.:.|.
 Frog   564 LGEILDSLSTHSSDPGAGRLTAAKSLDFFRSAEDLDYKVLNKTCPPTETNPSPMCLDSR------ 622

  Fly   548 NGHAYGASAGAHYGHHLAASPAV-SSASSLCSSSEMNLSQELQNHPLFKTPAVDRSLKPNA 607
            |....|......|..||..||.. |.....|..::...| |.....|..|.|...:::|.:
 Frog   623 NEWNLGQDDSVLYRKHLPPSPRKRSQDEQTCQGNDRRKS-EFPTIILTDTTAAGNTVRPTS 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	30/88 (34%)
		DENN	98..282	CDD:460461	78/201 (39%)
		dDENN	315..379	CDD:129037	26/64 (41%)
dennd1b	XP_012817957.1	uDENN	9..89	CDD:214824	31/91 (34%)
		DENN	94..291	CDD:214823	79/198 (40%)
		dDENN	323..388	CDD:129037	26/64 (41%)