DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstE13 and MARS1

DIOPT Version :9

Sequence 1:	NP_001188889.1	Gene:	GstE13 / 35928	FlyBaseID:	FBgn0033381	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	204	Identity:	38/204 - (18%)
Similarity:	67/204 - (32%)	Gaps:	80/204 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QIPVFVDSDGEVYVDSHAIVC---FLVAKYAGND-----------QLYPRDLKRRAHIDHRMHYE 104
            ::|| :..|...|:.|.:.:|   ||::.:..:|           :|.|.              .
Human    47 KVPV-LQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPA--------------L 96

  Fly   105 NGVLFQVVKDIVARNIYGGEGEYNPRSLTLCHNAYSDLEHFL--QQGSFVVGNELSVADV----- 162
            :..|:.:|       :.|.:||   ..|.....|.:.::|.|  |...|:.|...|:||:
Human    97 SAALYYLV-------VQGKKGE---DVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGA 151

  Fly   163 ----------------SIHTTLVTLDLLIPVER------------------EKYPQTKQWMERMD 193
                            ::|:...||....|.:|                  :|.||......|..
Human   152 LYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAV 216

  Fly   194 KLLPDNEEI 202
            ...|:.||:
Human   217 TNEPEEEEL 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstE13	NP_001188889.1	GST_N_Delta_Epsilon	4..78	CDD:239343	8/26 (31%)
GstE13	NP_001188889.1	GST_C_Delta_Epsilon	92..211	CDD:198287	27/152 (18%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	6/21 (29%)
		GstA	<47..189	CDD:223698	31/166 (19%)
		GST_C_MetRS_N	77..179	CDD:198340	21/125 (17%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810