Protein Alignment GstE13 and CLIC2

DIOPT Version :10

• Sequence 1: NP_610457.1
• Gene: GstE13 / 35928
• FlyBaseID: FBgn0033381
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 192
• Identity: 42/192 - (21%)
• Similarity: 76/192 - (39%)
• Gaps: 53/192 - (27%)

  Fly    30 ELKPVDFAKKEHLSEE------FVKLNPQHQIPVFVDSDGEVYVDSHAIVCFLVAKYAGNDQLYP 88
            ||| .||.|.|...|:      :..|:|:             |.:|..:.|.|.||::.    |.
Human    78 ELK-TDFIKIEEFLEQTLAPPRYPHLSPK-------------YKESFDVGCNLFAKFSA----YI 124

  Fly    89 RDLKRRAHIDHRMHYENGVL--FQVVKDIVARNIYGGEGEYNPRSLTLCHNAYSDLEHFLQQGSF 151
            ::.::.|:    .::|..:|  |:.:.|.:...:.   .|.:|.|..         |..:.:..|
Human   125 KNTQKEAN----KNFEKSLLKEFKRLDDYLNTPLL---DEIDPDSAE---------EPPVSRRLF 173

  Fly   152 VVGNELSVADVSIHTTLVTL--------DLLIPVERE---KYPQTKQWMERMDKLLPDNEEI 202
            :.|::|::||.|:...|..:        |..||.|..   :|.......|......|:::||
Human   174 LDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEI 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstE13	NP_610457.1	GstA	5..192	CDD:440390	39/180 (22%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		8/18 (44%)
		N-terminal	1..94		8/16 (50%)
		O-ClC	12..245	CDD:129941	42/192 (22%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		2/23 (9%)
		C-terminal	107..247		31/149 (21%)
		Foot loop	151..171		4/31 (13%)