Protein Alignment Su(var)2-10 and PIAS1

DIOPT Version :9

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: XP_011520428.1
• Gene: PIAS1 / 8554
• HGNCID: 2752
• Length: 660
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 243/657 - (36%)
• Similarity: 351/657 - (53%)
• Gaps: 110/657 - (16%)

  Fly    42 YKECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQ 105
            |.|| |||..|||.|||.:|.:...:..|||.:|.::.|..|:.... .:..|::|:|.:...::
Human    14 YYEC-QMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQK 77

  Fly   106 NATLQYIDPTRMYSHIQLPPTVQPN-----------------PVGLVGSGQGVQVPGGQMNVVGG 153
            ..|...:....::|. .:|.|:.|:                 ||.|:|....:::|
Human    78 IMTPADLSIPNVHSS-PMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELP--------- 132

  Fly   154 APFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIA 218
                  |..::..|:|||::|:||.|||:|..||||::|...|:||.:|..|.|.|||||..:|:
Human   133 ------HLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQIS 191

  Fly   219 SNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRP 283
            |:.|| :.:|.:..:||||||||.||||.|||.||||:.||||.|.|.||..:|..:..||||||
Human   192 SSMDI-SGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRP 255

  Fly   284 PRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGL 348
            .||:|:||.|:||.||.|||.|.|..:..|:|.:||||||:|:||.||||::.||::..|::|.|
Human   256 SRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRAL 320

  Fly   349 IKEKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPV 413
            ||||||.|.|.|||||.|:|||.||||||::.:||||.||||||||||:||:||||:||||.|||
Human   321 IKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPV 385

  Fly   414 CDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVI 478
            |||.|.|::|:|||.|.|:|...   :|..|||..:||:|:.  :||:.::.:
Human   386 CDKKAPYEHLIIDGLFMEILKYC---TDCDEIQFKEDGTWAP--MRSKKEVQE------------ 433

  Fly   479 SDDIELISDDAKPVKRDLSPAQDEQPTS---TSNS----ETVDLTL---SDSDDDMPLAKRRPPA 533
                  :|.....|...||...:.|..|   :||.    |.:|||:   ||.:::.|.|||..|:
Human   434 ------VSASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRTCPS 492

  Fly   534 KQAVASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAA--- 595
            ....:...:.|.         ...|.|:....:..|..:.:...::...:|..:|....|..
Human   493 LSPTSPLNNKGI---------LSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYD 548

  Fly   596 ----------------VHASLLESLAAAVADQKHF-------------QLLDLAAVAAAAAATAS 631
                            .:.|||.:.||||:|.:..             ..||..:...:.:...:
Human   549 LQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPTT 613

  Fly   632 SGQSQNA 638
            :|.|..:
Human   614 NGSSSGS 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	171..307	CDD:291022	77/135 (57%)
		zf-MIZ	368..417	CDD:280964	38/48 (79%)
PIAS1	XP_011520428.1	SAP	20..54	CDD:128789	13/33 (39%)
		PINIT	144..280	CDD:291022	77/136 (57%)
		zf-MIZ	340..388	CDD:280964	37/47 (79%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147224
Domainoid	1	1.000	172	1.000	Domainoid score	I3725
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22953
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1966
Isobase	1	0.950	-	0	Normalized mean entropy	S2460
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205949at2759
OrthoFinder	1	1.000	-	-		FOG0000526
OrthoInspector	1	1.000	-	-		otm40516
orthoMCL	1	0.900	-	-		OOG6_102691
Panther	1	1.100	-	-	O	PTHR10782
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	1	1.000	-	-		X350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.740