Protein Alignment Su(var)2-10 and SIZ1

DIOPT Version :10

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_010697.3
• Gene: SIZ1 / 852018
• SGDID: S000002817
• Length: 904
• Species: Saccharomyces cerevisiae
• Alignment Length: 534
• Identity: 132/534 - (24%)
• Similarity: 221/534 - (41%)
• Gaps: 120/534 - (22%)

  Fly    43 KECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAPKVQEVYAQSVQEQNA 107
            :|...::::|:|.||:.|...::...:|||..||..|.:||:.  .|:..|......|:|:....
Yeast    28 EETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQN--ALVVGKSDPYRVQAVKFLIE 90

  Fly   108 TLQYIDPTRMYSHI------------------QLPPTVQPNPVGLVGSGQGVQVPGGQMNVVGGA 154
            .::..:|..:|..:                  :.|||||.            |.|    :|:..:
Yeast    91 RIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQ------------QSP----SVIRQS 139

  Fly   155 PF----LHTHSINSQL--PIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFY--FTLTP 211
            |.    ..|.|..|:.  |.:||......:|            .||  |...:|.|||  ..|.|
Yeast   140 PTQRRKTSTTSSTSRAPPPTNPDASSSSSSF------------AVP--TIHFKESPFYKIQRLIP 190

  Fly   212 Q--QATEIASNRDIRNS----SKVEHAI----QVQLRFCL-------VETSCDQEDCFP-PNV-- 256
            :  ...|:...|.:.::    ||.::.:    ..:.|..|       :.:..::...|| ||.
Yeast   191 ELVMNVEVTGGRGMCSAKFKLSKADYNLLSNPNSKHRLYLFSGMINPLGSRGNEPIQFPFPNELR 255

  Fly   257 --NVKVNNKLCQLPNVIPTNRP-NVEPKRPPRPVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLA 318
              ||::.:.:....:...|.:| ::.|..  :|....:||:|....|           |:.|.|.
Yeast   256 CNNVQIKDNIRGFKSKPGTAKPADLTPHL--KPYTQQNNVELIYAFT-----------TKEYKLF 307

  Fly   319 VYLVKKLTSTQLLQRM--KTKGVKPADYTRGLIKEKLTEDADCEIATTMLKVSLNCPLGKMKMLL 381
            .|:|:.:|..|||:::  ..|.:|.|  |...:|:.|.||.:..:.||...:||.||:...:|..
Yeast   308 GYIVEMITPEQLLEKVLQHPKIIKQA--TLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKY 370

  Fly   382 PCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQ 446
            |.::..|.|||||||..:|....:.|||.||||......:||.|..:..::|.:  .:.:..:::
Yeast   371 PSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQN--CQKNVEQVE 433

  Fly   447 LHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSE 511
            |..||.|        |.||:.           .||.:..|:|........:...|...:|:..||
Yeast   434 LTSDGKW--------TAILED-----------DDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSE 479

  Fly   512 TVDLTLSDSDDDMP 525
            .:.:.| |||||.|
Yeast   480 PIIINL-DSDDDEP 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	11/33 (33%)
		PINIT	175..323	CDD:464136	34/172 (20%)
		SP-RING_PIAS	369..416	CDD:438444	22/46 (48%)
SIZ1	NP_010697.3	SAP	34..68	CDD:128789	11/33 (33%)
		PINIT	178..312	CDD:464136	30/146 (21%)
		SP-RING_ScSiz-like	354..409	CDD:438447	22/54 (41%)