DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)2-10 and ZMIZ2

DIOPT Version :9

Sequence 1:	NP_724749.1	Gene:	Su(var)2-10 / 35927	FlyBaseID:	FBgn0003612	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_005249923.1	Gene:	ZMIZ2 / 83637	HGNCID:	22229	Length:	929	Species:	Homo sapiens

Alignment Length:	664	Identity:	164/664 - (24%)
Similarity:	242/664 - (36%)	Gaps:	198/664 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YAQSVQEQNATLQYID-------PTRMYSHIQLPPTVQ---------PNPVGL------VGSGQG 140
            |.|..|...:|.|:..       |:..|...:||  :|         |.|.||      ..:|||
Human   278 YLQGGQYAPSTAQFAPSPGQPPAPSPSYPGHRLP--LQQGMTQSLSVPGPTGLHYKPTEQFNGQG 340

  Fly   141 VQVPGGQMNVVGGAPFLH--THSI----NSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQR 199
            ....||.::.  ..|.|.  |.||    :|.||.:|...:             .||:.||..:..
Human   341 ASFNGGSVSY--SQPGLSGPTRSIPGYPSSPLPGNPTPPM-------------TPSSSVPYMSPN 390

  Fly   200 VQEV--PFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETS--CDQ------------ 248
             |||  ||...|.|        |.:..:||...|:     ::.|:..|  ||:
Human   391 -QEVKSPFLPDLKP--------NLNSLHSSPSAHS-----QWPLLPGSGPCDELRLTFPVRDGVV 441

  Fly   249 EDCFPPNVNVKVNNKLCQL-----------PNV-------------IPTNRP-------NVEPKR 282
            .:.|....|:.|:|.:.||           |::             :.||.|       |..|..
Human   442 LEPFRLQHNLAVSNHVFQLRDSVYKTLIMRPDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLT 506

  Fly   283 PPRPVNVTSNVKL------SP---TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKG 338
            ..|..|.||:..|      .|   |:..|:|...|     |:...:.||.:.:...:||.:..|.
Human   507 IERGDNKTSHKPLYLKHVCQPGRNTIQITVTACCC-----SHLFVLQLVHRPSVRSVLQGLLKKR 566

  Fly   339 VKPADYTRGLIKEKLT------------EDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHL 391
            :.||::....||...:            ||.   :..|.:||||.||:...::.||.|...|.|:
Human   567 LLPAEHCITKIKRNFSSGTIPGTPGPNGEDG---VEQTAIKVSLKCPITFRRIQLPARGHDCRHI 628

  Fly   392 QCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTP 456
            ||||...|||:|..:.||.||||:|.|:.:.|.:|.|...:| ..:..||..||.:....||...
Human   629 QCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGIL-IYIQNSDYEEITIDPTCSWKPV 692

  Fly   457 GLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSD 521
            .::.:..|.:.|..||.|                 ..|.:|||....|:      .:::..:...
Human   693 PVKPDMHIKEEPDGPALK-----------------RCRTVSPAHVLMPS------VMEMIAALGP 734

  Fly   522 DDMPLAKRRPPAKQAVASSTSNGS---GGGQ---------------RAYTPAQQP--QQSESPEQ 566
            ...|.|..:||:..|.:.....||   |.|.               ..:||...|  .||:.|
Human   735 GAAPFAPLQPPSVPAPSDYPGQGSSFLGPGTFPESFPPTTPSTPTLAEFTPGPPPISYQSDIP-- 797

  Fly   567 QASRQSPEKQTVS-EQQLQQQQH----EQPATAAVHASLLESLAAAVADQKHFQLLDLAAVAAAA 626
             :|..:.||.|.. ..|:....|    ..|.|..:|.|   :|.|....|.|..       ....
Human   798 -SSLLTSEKSTACLPSQMAPAGHLDPTHNPGTPGLHTS---NLGAPPGPQLHHS-------NPPP 851

  Fly   627 AATASSGQSQNAGP 640
            |:..|.||: :.||
Human   852 ASRQSLGQA-SLGP 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789
		PINIT	171..307	CDD:291022	40/191 (21%)
		zf-MIZ	368..417	CDD:280964	24/48 (50%)
ZMIZ2	XP_005249923.1	zf-MIZ	605..653	CDD:280964	24/47 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840