Protein Alignment Su(var)2-10 and Pias4

DIOPT Version :10

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_067476.2
• Gene: Pias4 / 59004
• MGIID: 2136940
• Length: 507
• Species: Mus musculus
• Alignment Length: 540
• Identity: 212/540 - (39%)
• Similarity: 304/540 - (56%)
• Gaps: 89/540 - (16%)

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQNA 107
            |.:.||...||.:||.:|.|:..|.:|.|.:|.:|.|..::.:.. .|..|::|:|.....:::|
Mouse     7 EAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSA 71

  Fly   108 -----TLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVP---GGQMNVVGGAPFLHTHSINS 164
                 ..:.:||..::|   :|.|    |:    ||..|..|   |..:|.:|..|   |.::.
Mouse    72 EPGPQAPRPLDPLALHS---MPRT----PL----SGPTVDYPVLYGKYLNGLGRLP---TKTLK- 121

  Fly   165 QLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKV 229
                 |:|||.||.|:::|..|:||:.|||::.:::||.|..|.|||:|...|.::|:::...|
Mouse   122 -----PEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVK- 180

  Fly   230 EHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVK 294
              |:||.||.|..:|||.|||.:|||:.||||:..|.:|...|:|:|.||||||.||:|:|..:.
Mouse   181 --AVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMY 243

  Fly   295 LSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADC 359
            || :.||.|||.| .:|.:||.:|:|||::|||:.||||:||.|||..:..:.|:||||..|.|.
Mouse   244 LS-SATNRITVTW-GNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDS 306

  Fly   360 EIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLV 424
            |||||.::|||.|||.||::.:||||.||:|||||||..||||||:||||.||||||||.||.|:
Mouse   307 EIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLI 371

  Fly   425 IDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDA 489
            |||...::|  |..:..| ||:...:|||..  :|:|.:...:|..|.         :.|.:.||
Mouse   372 IDGLLSKIL--SECEGAD-EIEFLAEGSWRP--IRAEKEPSCSPQGPI---------LVLGTSDA 422

  Fly   490 KPVKRDLSPAQD--------EQPTST--------------SNSETVDLTL----------SDSDD 522
                ..|:||..        ..|.|.              :.::.|||||          .|.||
Mouse   423 ----NGLAPASSTPGIGSGLSGPGSAGSGAGAAGSLENGKTGADVVDLTLDSSSSSEDEDEDEDD 483

  Fly   523 DM-----PLAKRRPPAKQAV 537
            |.     |..|||.|.::.:
Mouse   484 DEDEDEGPRPKRRCPFQKGL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	175..323	CDD:464136	69/147 (47%)
		SP-RING_PIAS	369..416	CDD:438444	34/46 (74%)
Pias4	NP_067476.2	SAP	12..46	CDD:128789	13/33 (39%)
		LXXLL motif	20..24		2/3 (67%)
		PINIT	127..270	CDD:464136	69/147 (47%)
		SP-RING_PIAS4	311..368	CDD:438470	40/56 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..507		18/78 (23%)