DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-10 and Pias4

DIOPT Version :9

Sequence 1:	NP_724749.1	Gene:	Su(var)2-10 / 35927	FlyBaseID:	FBgn0003612	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_067476.2	Gene:	Pias4 / 59004	MGIID:	2136940	Length:	507	Species:	Mus musculus

Alignment Length:	540	Identity:	212/540 - (39%)
Similarity:	304/540 - (56%)	Gaps:	89/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQNA 107
            |.:.||...||.:||.:|.|:..|.:|.|.:|.:|.|..::.:.. .|..|::|:|.....:::|
Mouse     7 EAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSA 71

  Fly   108 -----TLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVP---GGQMNVVGGAPFLHTHSINS 164
                 ..:.:||..::|   :|.|    |:    ||..|..|   |..:|.:|..|   |.::.
Mouse    72 EPGPQAPRPLDPLALHS---MPRT----PL----SGPTVDYPVLYGKYLNGLGRLP---TKTLK- 121

  Fly   165 QLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKV 229
                 |:|||.||.|:::|..|:||:.|||::.:::||.|..|.|||:|...|.::|:::...|
Mouse   122 -----PEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVK- 180

  Fly   230 EHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVK 294
              |:||.||.|..:|||.|||.:|||:.||||:..|.:|...|:|:|.||||||.||:|:|..:.
Mouse   181 --AVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMY 243

  Fly   295 LSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADC 359
            || :.||.|||.| .:|.:||.:|:|||::|||:.||||:||.|||..:..:.|:||||..|.|.
Mouse   244 LS-SATNRITVTW-GNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDS 306

  Fly   360 EIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLV 424
            |||||.::|||.|||.||::.:||||.||:|||||||..||||||:||||.||||||||.||.|:
Mouse   307 EIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLI 371

  Fly   425 IDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDA 489
            |||...::|  |..:..| ||:...:|||..  :|:|.:...:|..|.         :.|.:.||
Mouse   372 IDGLLSKIL--SECEGAD-EIEFLAEGSWRP--IRAEKEPSCSPQGPI---------LVLGTSDA 422

  Fly   490 KPVKRDLSPAQD--------EQPTST--------------SNSETVDLTL----------SDSDD 522
                ..|:||..        ..|.|.              :.::.|||||          .|.||
Mouse   423 ----NGLAPASSTPGIGSGLSGPGSAGSGAGAAGSLENGKTGADVVDLTLDSSSSSEDEDEDEDD 483

  Fly   523 DM-----PLAKRRPPAKQAV 537
            |.     |..|||.|.::.:
Mouse   484 DEDEDEGPRPKRRCPFQKGL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	171..307	CDD:291022	65/135 (48%)
		zf-MIZ	368..417	CDD:280964	36/48 (75%)
Pias4	NP_067476.2	SAP	12..46	CDD:128789	13/33 (39%)
		LXXLL motif	20..24		2/3 (67%)
		PINIT	124..262	CDD:291022	67/142 (47%)
		zf-MIZ	315..364	CDD:280964	36/48 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..507		18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837154
Domainoid	1	1.000	95	1.000	Domainoid score	I7382
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205949at2759
OrthoFinder	1	1.000	-	-		FOG0000526
OrthoInspector	1	1.000	-	-		otm42590
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	1	1.000	-	-		X350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840