Protein Alignment Su(var)2-10 and ZMIZ1

DIOPT Version :9

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: XP_005270044.1
• Gene: ZMIZ1 / 57178
• HGNCID: 16493
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 127/560 - (22%)
• Similarity: 194/560 - (34%)
• Gaps: 168/560 - (30%)

  Fly   114 PTRMYSHIQLP--PTVQPNPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKK 176
            |...|.|..:|  ||....|        |..:|          |:| :.|.:.:.|..||
Human   509 PVANYPHSPVPGNPTPPMTP--------GSSIP----------PYL-SPSQDVKPPFPPD----- 549

  Fly   177 LAFYDVLGTLIKP--STLVPRNTQRVQEVPFYFTLTPQQATEIASNRD--IRNSSKVEHAIQV-- 235
                      |||  |.|.|.......|:...|.:           ||  :....::||.:.|
Human   550 ----------IKPNMSALPPPPANHNDELRLTFPV-----------RDGVVLEPFRLEHNLAVSN 593

  Fly   236 ---QLRFCLVETSCDQED------CF-----------PPNVNVKVNNKLCQLPNVIPTNRPNVEP 280
               .||..:.:|...:.|      |:           |.:|.|.|                |..|
Human   594 HVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSV----------------NATP 642

  Fly   281 KRPPRPVNVTSNVKL------SP---TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKT 336
            ....|..|.||:..|      .|   |:..|:|...|     |:...:.||.:.:...:||.:..
Human   643 LTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCC-----SHLFVLQLVHRPSVRSVLQGLLK 702

  Fly   337 KGVKPADYTRGLIKEKL----------TEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHL 391
            |.:.||::....||...          |.:.:..:..|.:||||.||:...::.||.|...|.|:
Human   703 KRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHV 767

  Fly   392 QCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTP 456
            ||||...|||:|..:.||.||||:|.|:.:.|.:|.|...:| :::..|:..|:.:....||...
Human   768 QCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGIL-NAIQHSEFEEVTIDPTCSWRPV 831

  Fly   457 GLRSETQILDTPSKPAQKVEVISDDIELISDDAKPVKR--DLSPAQDEQPTSTSNSETVDLTLSD 519
            .::|:..|.|.|                   |..|.||  .:||:|...|    |...:...|..
Human   832 PIKSDLHIKDDP-------------------DGIPSKRFKTMSPSQMIMP----NVMEMIAALGP 873

  Fly   520 SDDDMPLAKRRPPAKQAVASSTSNGSGGGQRA--------------------YTPAQQPQQSESP 564
            .....||    ||......|:..:..|...:.                    :.|.|.....:.|
Human   874 GPSPYPL----PPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMP 934

  Fly   565 EQQASRQSPEKQTVSEQQLQQQQHEQPATAAVHASLLESL 604
            ...|:.:.|....:.|........:||     |.|:.:.|
Human   935 NNMAALEKPLSHPMQETMPHAGSSDQP-----HPSIQQGL 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789
		PINIT	171..307	CDD:291022	34/170 (20%)
		zf-MIZ	368..417	CDD:280964	24/48 (50%)
ZMIZ1	XP_005270044.1	Zmiz1_N	8..100	CDD:375500
		Med15	184..>563	CDD:312941	21/87 (24%)
		SP-RING_ZMIZ	745..792	CDD:319705	23/46 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840