DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)2-10 and Pias1

DIOPT Version :9

Sequence 1:NP_724749.1 Gene:Su(var)2-10 / 35927 FlyBaseID:FBgn0003612 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_062637.2 Gene:Pias1 / 56469 MGIID:1913125 Length:651 Species:Mus musculus


Alignment Length:654 Identity:245/654 - (37%)
Similarity:352/654 - (53%) Gaps:107/654 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQNA 107
            |.:|||..|||.|||.:|.:...:..|||.:|.::.|..|:.... .:..|::|:|.:...::..
Mouse     6 ELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIM 70

  Fly   108 TLQYIDPTRMYSHIQLPPTVQPN-----------------PVGLVGSGQGVQVPGGQMNVVGGAP 155
            |...:....::|. .:|||:.|:                 ||.|:|....:::|           
Mouse    71 TPADLSIPNVHSS-PMPPTLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELP----------- 123

  Fly   156 FLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASN 220
                |..::..|:|||::|:||.|||:|..||||::|...|:||.:|..|.|.|||||..:|:|:
Mouse   124 ----HLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSS 184

  Fly   221 RDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPR 285
            .|| :.:|.:..:||||||||.||||.|||.||||:.||||.|.|.||..:|..:..||||||.|
Mouse   185 MDI-SGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSR 248

  Fly   286 PVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIK 350
            |:|:||.|:||.||.|||.|.|..:..|:|.:||||||:|:||.||||::.||::..|::|.|||
Mouse   249 PINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIK 313

  Fly   351 EKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCD 415
            ||||.|.|.|||||.|:|||.||||||::.:||||.||||||||||:||:||||:||||.|||||
Mouse   314 EKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCD 378

  Fly   416 KPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISD 480
            |.|.|::|:|||.|.|:|...   :|..|||..:||||:.  :||:.::.:              
Mouse   379 KKAPYEHLIIDGLFMEILKYC---TDCDEIQFKEDGSWAP--MRSKKEVQE-------------- 424

  Fly   481 DIELISDDAKPVKRDLSPAQDEQPTSTSNS-------ETVDLTLSDSDDDMPLAKRRPPAKQAV- 537
                ::.....|...||...:.|..|.:.|       |.:|||:..|.|:   .:..||||:.. 
Mouse   425 ----VTASYNGVDGCLSSTLEHQVASHNQSSNKNKKVEVIDLTIDSSSDE---EEEEPPAKRTCP 482

  Fly   538 -ASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAA------ 595
             .|.||..|..|..:.     |.|:....:..|..:.:...::...:|..:|....|..      
Mouse   483 SLSPTSPLSNKGILSL-----PHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQG 542

  Fly   596 -------------VHASLLESLAAAVADQKHF-------------QLLDLAAVAAAAAATASSGQ 634
                         .:.|||.:.||||:|.:..             ..||..:...:.:..|::|.
Mouse   543 LDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGS 607

  Fly   635 SQNA 638
            |..:
Mouse   608 SSGS 611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)2-10NP_724749.1 SAP 49..83 CDD:128789 13/33 (39%)
PINIT 171..307 CDD:291022 77/135 (57%)
zf-MIZ 368..417 CDD:280964 38/48 (79%)
Pias1NP_062637.2 SAP 11..45 CDD:128789 13/33 (39%)
LXXLL motif 19..23 2/3 (67%)
Nuclear localization signal. /evidence=ECO:0000255 56..64 3/7 (43%)
PINIT 137..280 CDD:373014 79/143 (55%)
COG5222 <313..428 CDD:227547 71/137 (52%)
SP-RING_PIAS 332..379 CDD:319704 36/46 (78%)
SP-RING finger 335..377 CDD:319704 32/41 (78%)
Nuclear localization signal. /evidence=ECO:0000255 368..380 9/11 (82%)
SUMO1-binding. /evidence=ECO:0000250 462..473 4/13 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..511 13/53 (25%)
4 X 4 AA repeats of N-T-S-L 520..615 16/92 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..630 3/12 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837153
Domainoid 1 1.000 172 1.000 Domainoid score I3705
eggNOG 1 0.900 - - E1_KOG2169
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22953
Inparanoid 1 1.050 400 1.000 Inparanoid score I1924
Isobase 1 0.950 - 0 Normalized mean entropy S2460
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1205949at2759
OrthoFinder 1 1.000 - - FOG0000526
OrthoInspector 1 1.000 - - otm42590
orthoMCL 1 0.900 - - OOG6_102691
Panther 1 1.100 - - O PTHR10782
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3884
SonicParanoid 1 1.000 - - X350
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

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