DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)2-10 and Zmiz2

DIOPT Version :9

Sequence 1:	NP_724749.1	Gene:	Su(var)2-10 / 35927	FlyBaseID:	FBgn0003612	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_082877.2	Gene:	Zmiz2 / 52915	MGIID:	106374	Length:	920	Species:	Mus musculus

Alignment Length:	609	Identity:	143/609 - (23%)
Similarity:	215/609 - (35%)	Gaps:	186/609 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YAQSVQEQNATLQYI-------DPTRMYSHIQLP-------PTVQPNPVGL------VGSGQGVQ 142
            |.|..|....|.||.       .|...|:..:||       ....|.|.||      ..:|||..
Mouse   278 YLQGGQYAANTAQYAPGPGQPPGPASSYAGHRLPLQQGMAQSLSAPGPTGLHYKPTEQFNGQGAS 342

  Fly   143 VPGGQMNV-----------VGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRN 196
            ..||.::.           :.|.|       :|.||.:|...:             .||:.||..
Mouse   343 FNGGSISYSQPGLSGPSRSIPGYP-------SSPLPGNPTPPM-------------TPSSNVPYM 387

  Fly   197 TQRVQEV--PFYFTLTPQQAT------------EIASNRDIRNS-----SKVEHAIQV-----QL 237
            :.. |||  ||...|.|..::            |:.....:|:.     .:::|.:.|     ||
Mouse   388 SPS-QEVKSPFLPDLKPGLSSLHPSPSASVHCDELRLTFPVRDGVVLEPFRLQHNLAVSNHVFQL 451

  Fly   238 RFCLVETSCDQED------CF-----------PPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPR 285
            |..:.:|...:.|      |:           |.:|.|.|                |..|....|
Mouse   452 RDSVYKTLMLRPDLELQFKCYHHEDRQMNTNWPASVQVSV----------------NATPLSIER 500

  Fly   286 PVNVTSNVKL------SP---TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKP 341
            ..|.||:..|      .|   |:..|:|...|     |:...:.||.:.:...:||.:..|.:.|
Mouse   501 GDNKTSHKPLYLKHVCQPGRNTIQITVTACCC-----SHLFVLQLVHRPSVRSVLQGLLKKRLLP 560

  Fly   342 ADYTRGLIKEKLT------------EDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCF 394
            |::....||...:            ||.   :..|.:||||.||:...::.||.|...|.|:|||
Mouse   561 AEHCITKIKRNFSSGTIPGTPGPNGEDG---VEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCF 622

  Fly   395 DASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLR 459
            |...|||:|..:.||.||||:|.|:.:.|.:|.|...:| ..:..||..||.:....||....::
Mouse   623 DLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGIL-IYIQNSDYEEITIDPTCSWKPVPVK 686

  Fly   460 SETQILDTPSKPAQKVEVISDDIELISDDAKPVKRDLSPAQDEQPTSTSNSETVDLTLSDSDDDM 524
            .:..|.:.|..|..|                 ..|.:|||....|:      .:::..:......
Mouse   687 PDLHIKEEPDGPVLK-----------------RCRTVSPAHVLMPS------VMEMIAALGPGAA 728

  Fly   525 PLAKRRPPAKQAVASSTSNGS---GGGQ---------------RAYTPAQQP--QQSESPEQQAS 569
            |.|..:||:....:...|.||   |.|.               ..:|....|  .||:.|   :|
Mouse   729 PFAPLQPPSAPTPSDYPSQGSNFMGPGTFPESFPSATPTTPNLAEFTQGPPPISYQSDIP---SS 790

  Fly   570 RQSPEKQT-VSEQQLQQQQHEQPA 592
            ..:|:|.| ....|:....|..||
Mouse   791 LLTPDKSTPCLPGQMAPAGHLDPA 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789
		PINIT	171..307	CDD:291022	36/185 (19%)
		zf-MIZ	368..417	CDD:280964	24/48 (50%)
Zmiz2	NP_082877.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..262
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..308		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..408		26/111 (23%)
		Interaction with AR. /evidence=ECO:0000250	435..506		16/86 (19%)
		SP-RING_ZMIZ	597..644	CDD:319705	23/46 (50%)
		SP-RING finger	600..642	CDD:319705	19/41 (46%)
		PHA03307	714..>887	CDD:223039	23/110 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..920		20/86 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840