DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)2-10 and pias4a

DIOPT Version :9

Sequence 1:	NP_724749.1	Gene:	Su(var)2-10 / 35927	FlyBaseID:	FBgn0003612	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_998568.2	Gene:	pias4a / 406712	ZFINID:	ZDB-GENE-040426-2734	Length:	505	Species:	Danio rerio

Alignment Length:	550	Identity:	191/550 - (34%)
Similarity:	274/550 - (49%)	Gaps:	88/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNL--ELLAPKVQEVYAQSVQEQN 106
            |...||:..||.:||.:|:.:..|.:|.|.||..|.|..::|..  ||| ..|:::|.....:.:
Zfish     7 EAMNMVKSFRVSDLQTLLASMGRSKSGLKQDLVGRALRLVQTEYSPELL-KNVRQLYETRFPKAS 70

  Fly   107 ATLQYIDPTRMYSHIQLPPTVQPNPVGL----VGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLP 167
            |.|.          .:.|.||..|...|    .|:|||.....|   :...||           |
Zfish    71 AWLA----------ARRPETVAVNYPALNSSPRGTGQGTDYLNG---IPKPAP-----------P 111

  Fly   168 IHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHA 232
            ...:|:|..|.||..|.||:.|:.||.:|::::||....|.|||.|..:|.::.::|...|   :
Zfish   112 PAAEVKLVPLPFYHNLETLLPPTELVAQNSEKLQESQCVFDLTPNQVDQIRNSSELRPGMK---S 173

  Fly   233 IQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSP 297
            :||.||.|..::...|||.:|||:.||||...|.:|...|:|:|.|||:||.||||:|..:.||
Zfish   174 VQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEPRRPCRPVNITPWLHLS- 237

  Fly   298 TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIA 362
            ||||.:|:.| .::.:.|.:|||||:..||.:|..::|...|:..|..|..|::||..|.:.|||
Zfish   238 TVTNRVTITW-GNFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQDKLRFDPESEIA 301

  Fly   363 TTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDG 427
            ||.|:|||.|||.||::.:|||..||:|||||||..:|||||:||||.||||||||.::.|.|||
Zfish   302 TTGLRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQMNEKKPTWTCPVCDKPAPFELLTIDG 366

  Fly   428 YFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPV 492
            ...|:|..:  ..|..||:...||||                                    :|:
Zfish   367 LLSEILKET--PEDVEEIEYLTDGSW------------------------------------RPI 393

  Fly   493 KRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMP-------LAKRRPPAKQAVASSTSNGSGGGQR 550
            :.|....::.:.:.|.:...||:.:.:::...|       ..|.......|...|||.|||||..
Zfish   394 RDDKEKERERENSRTPDYPVVDICVPEANGHSPAHSGTNQTGKSGSGGASAGTGSTSGGSGGGTV 458

  Fly   551 AYTPAQQPQQSE-------SPEQQASRQSP 573
            .........:.|       |.|...|:.||
Zfish   459 VDLTLDDSSEEEGGGGAEDSEETDDSQDSP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	171..307	CDD:291022	59/135 (44%)
		zf-MIZ	368..417	CDD:280964	34/48 (71%)
pias4a	NP_998568.2	SAP	12..46	CDD:128789	13/33 (39%)
		LXXLL motif. /evidence=ECO:0000250\|UniProtKB:Q8N2W9	20..24		2/3 (67%)
		PINIT	116..254	CDD:291022	60/142 (42%)
		zf-MIZ	307..356	CDD:280964	34/48 (71%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:22345667	374..505		28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..505		20/93 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205949at2759
OrthoFinder	1	1.000	-	-		FOG0000526
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	1	1.000	-	-		X350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840