Protein Alignment Su(var)2-10 and pias4a

DIOPT Version :10

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_998568.2
• Gene: pias4a / 406712
• ZFINID: ZDB-GENE-040426-2734
• Length: 505
• Species: Danio rerio
• Alignment Length: 550
• Identity: 191/550 - (34%)
• Similarity: 274/550 - (49%)
• Gaps: 88/550 - (16%)

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNL--ELLAPKVQEVYAQSVQEQN 106
            |...||:..||.:||.:|:.:..|.:|.|.||..|.|..::|..  ||| ..|:::|.....:.:
Zfish     7 EAMNMVKSFRVSDLQTLLASMGRSKSGLKQDLVGRALRLVQTEYSPELL-KNVRQLYETRFPKAS 70

  Fly   107 ATLQYIDPTRMYSHIQLPPTVQPNPVGL----VGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLP 167
            |.|.          .:.|.||..|...|    .|:|||.....|   :...||           |
Zfish    71 AWLA----------ARRPETVAVNYPALNSSPRGTGQGTDYLNG---IPKPAP-----------P 111

  Fly   168 IHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHA 232
            ...:|:|..|.||..|.||:.|:.||.:|::::||....|.|||.|..:|.::.::|...|   :
Zfish   112 PAAEVKLVPLPFYHNLETLLPPTELVAQNSEKLQESQCVFDLTPNQVDQIRNSSELRPGMK---S 173

  Fly   233 IQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSP 297
            :||.||.|..::...|||.:|||:.||||...|.:|...|:|:|.|||:||.||||:|..:.||
Zfish   174 VQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEPRRPCRPVNITPWLHLS- 237

  Fly   298 TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIA 362
            ||||.:|:.| .::.:.|.:|||||:..||.:|..::|...|:..|..|..|::||..|.:.|||
Zfish   238 TVTNRVTITW-GNFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQDKLRFDPESEIA 301

  Fly   363 TTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDG 427
            ||.|:|||.|||.||::.:|||..||:|||||||..:|||||:||||.||||||||.::.|.|||
Zfish   302 TTGLRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQMNEKKPTWTCPVCDKPAPFELLTIDG 366

  Fly   428 YFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDAKPV 492
            ...|:|..:  ..|..||:...||||                                    :|:
Zfish   367 LLSEILKET--PEDVEEIEYLTDGSW------------------------------------RPI 393

  Fly   493 KRDLSPAQDEQPTSTSNSETVDLTLSDSDDDMP-------LAKRRPPAKQAVASSTSNGSGGGQR 550
            :.|....::.:.:.|.:...||:.:.:::...|       ..|.......|...|||.|||||..
Zfish   394 RDDKEKERERENSRTPDYPVVDICVPEANGHSPAHSGTNQTGKSGSGGASAGTGSTSGGSGGGTV 458

  Fly   551 AYTPAQQPQQSE-------SPEQQASRQSP 573
            .........:.|       |.|...|:.||
Zfish   459 VDLTLDDSSEEEGGGGAEDSEETDDSQDSP 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	175..323	CDD:464136	63/147 (43%)
		SP-RING_PIAS	369..416	CDD:438444	32/46 (70%)
pias4a	NP_998568.2	SAP	12..46	CDD:128789	13/33 (39%)
		LXXLL motif. /evidence=ECO:0000250|UniProtKB:Q8N2W9	20..24		2/3 (67%)
		PINIT	119..262	CDD:464136	63/147 (43%)
		SP-RING_PIAS4	303..360	CDD:438470	39/56 (70%)
		Required for nuclear localization. /evidence=ECO:0000269|PubMed:22345667	374..505		28/152 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..505		20/93 (22%)