Protein Alignment Su(var)2-10 and Pias4

DIOPT Version :9

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001094227.1
• Gene: Pias4 / 362827
• RGDID: 1308737
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 208/540 - (38%)
• Similarity: 300/540 - (55%)
• Gaps: 89/540 - (16%)

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQNA 107
            |.:.||...||.:||.:|.|:..|.:|.|.:|.:|.|..::.:.. .|..|::|:|.....:::|
  Rat     7 EAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSA 71

  Fly   108 -----TLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQGVQVP---GGQMNVVGGAPFLHTHSINS 164
                 ..:.:||..::|   :|.|    |:    ||..|..|   |..:|.:|..|   |.::.
  Rat    72 EPGPQAPRPLDPLALHS---MPRT----PL----SGPTVDYPVLYGKYLNGLGRLP---TKALK- 121

  Fly   165 QLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKV 229
                 |:|||.||.|:::|..|:||:.|||::.:::||.|..|.|||:|...|.::|:::...|
  Rat   122 -----PEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVK- 180

  Fly   230 EHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVK 294
              |:||.||.|..:|||.|||.:|||:.||||:..|.:|...|:|:|.||||||.||:|:|..:.
  Rat   181 --AVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMY 243

  Fly   295 LSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADC 359
            || :.||.|||.| .:|.:||.:|:|||::|||:.||||:||.|||..:..:.|:||||..|.|.
  Rat   244 LS-SATNRITVTW-GNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDS 306

  Fly   360 EIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLV 424
            |||||.::|||.|||.||::.:||||.||:|||||||..||||||:||||.||||||||.||.|:
  Rat   307 EIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLI 371

  Fly   425 IDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDDIELISDDA 489
            |||...::|...   .|..||:...:|||..  :|:|.:...:|..|.         :.|.:.||
  Rat   372 IDGLLSKILSEC---EDADEIEFLAEGSWRP--IRAEKEPSCSPQGPI---------LVLGTSDA 422

  Fly   490 KPVKRDLSPAQDEQ----------------------PTSTSNSETVDLTLSDS------------ 520
                ..|:||....                      ....:.::.|||||..|
  Rat   423 ----NGLAPASSTPGMGSGLSGPGGAGGGAGAAGGLENGKTGADVVDLTLDSSSSSEDEDEDEDD 483

  Fly   521 ---DDDMPLAKRRPPAKQAV 537
               ||:.|..|||.|.::.:
  Rat   484 DEDDDEGPRPKRRCPFQKGL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	171..307	CDD:291022	65/135 (48%)
		zf-MIZ	368..417	CDD:280964	36/48 (75%)
Pias4	NP_001094227.1	SAP	12..46	CDD:128789	13/33 (39%)
		PINIT	124..262	CDD:291022	67/142 (47%)
		zf-MIZ	315..364	CDD:280964	36/48 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340872
Domainoid	1	1.000	95	1.000	Domainoid score	I7210
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205949at2759
OrthoFinder	1	1.000	-	-		FOG0000526
OrthoInspector	1	1.000	-	-		otm44659
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.810