DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)2-10 and Zmiz1

DIOPT Version :9

Sequence 1:NP_724749.1 Gene:Su(var)2-10 / 35927 FlyBaseID:FBgn0003612 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_899031.2 Gene:Zmiz1 / 328365 MGIID:3040693 Length:1072 Species:Mus musculus


Alignment Length:605 Identity:135/605 - (22%)
Similarity:208/605 - (34%) Gaps:188/605 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 QSVQEQNATLQYIDPT-------------------------RMYSH--IQLPPTVQPNPVG---- 133
            |.:..|.:|.||..||                         ..||.  :..||  :|.||.    
Mouse   454 QRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPP--RPVPVANYPH 516

  Fly   134 --LVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKP--STLVP 194
              :.|:......||..:     .|:| :.|.:.:.|..||               |||  |.|.|
Mouse   517 SPVPGNPTPPMTPGSSI-----PPYL-SPSQDVKPPFPPD---------------IKPNMSALPP 560

  Fly   195 RNTQRVQEVPFYFTLTPQQATEIASNRD--IRNSSKVEHAIQV-----QLRFCLVETSCDQED-- 250
            .......|:...|.:           ||  :....::||.:.|     .||..:.:|...:.|  
Mouse   561 PPANHNDELRLTFPV-----------RDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLE 614

  Fly   251 ----CF-----------PPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKL----- 295
                |:           |.:|.|.|                |..|....|..|.||:..|     
Mouse   615 LQFKCYHHEDRQMNTNWPASVQVSV----------------NATPLTIERGDNKTSHKPLHLKHV 663

  Fly   296 -SP---TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKL--- 353
             .|   |:..|:|...|     |:...:.||.:.:...:||.:..|.:.||::....||...   
Mouse   664 CQPGRNTIQITVTACCC-----SHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSV 723

  Fly   354 -------TEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNC 411
                   |.:.:..:..|.:||||.||:...::.||.|...|.|:||||...|||:|..:.||.|
Mouse   724 AASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRC 788

  Fly   412 PVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVE 476
            |||:|.|:.:.|.:|.|...:| :::..|:..|:.:....||....::|:..|.|.|        
Mouse   789 PVCNKTALLEGLEVDQYMWGIL-NAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDP-------- 844

  Fly   477 VISDDIELISDDAKPVKR--DLSPAQDEQPTSTSNSETVDLTLSDSDDDMPLAKRRPPAKQAVAS 539
                       |..|.||  .:||:|...|    |...:...|.......||    ||.....:|
Mouse   845 -----------DGIPSKRFKTMSPSQMIMP----NVMEMIAALGPGPSPYPL----PPPPGGTSS 890

  Fly   540 STSNGSGGGQRA--------------------YTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQ 584
            :..:..|...:.                    :.|.|.....:.|...|:.:.|....:.|....
Mouse   891 NDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPH 955

  Fly   585 QQQHEQPATAAVHASLLESL 604
            ....:||     |.|:.:.|
Mouse   956 AGSSDQP-----HPSIQQGL 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)2-10NP_724749.1 SAP 49..83 CDD:128789
PINIT 171..307 CDD:291022 34/170 (20%)
zf-MIZ 368..417 CDD:280964 24/48 (50%)
Zmiz1NP_899031.2 Sufficient for transactivation activity, sufficient for interaction with NOTCH1. /evidence=ECO:0000250|UniProtKB:Q9ULJ6 1..120
Zmiz1_N 8..100 CDD:375500
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..141
PHA03247 <119..546 CDD:223021 20/99 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..538 19/91 (21%)
SP-RING_ZMIZ 746..793 CDD:319705 23/46 (50%)
Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q9ULJ6 844..1072 28/159 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..1072 17/105 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3884
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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