Protein Alignment Su(var)2-10 and Pias1

DIOPT Version :9

• Sequence 1: NP_724749.1
• Gene: Su(var)2-10 / 35927
• FlyBaseID: FBgn0003612
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001100299.3
• Gene: Pias1 / 300772
• RGDID: 1307843
• Length: 651
• Species: Rattus norvegicus
• Alignment Length: 654
• Identity: 244/654 - (37%)
• Similarity: 351/654 - (53%)
• Gaps: 107/654 - (16%)

  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLE-LLAPKVQEVYAQSVQEQNA 107
            |.:|||..|||.|||.:|.:...:..|||.:|.::.|..|:.... .:..|::|:|.:...::..
  Rat     6 ELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIM 70

  Fly   108 TLQYIDPTRMYSHIQLPPTVQPN-----------------PVGLVGSGQGVQVPGGQMNVVGGAP 155
            |...:....::|. .:|.|:.|:                 ||.|:|....:::|
  Rat    71 TPADLSIPNVHSS-PMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELP----------- 123

  Fly   156 FLHTHSINSQLPIHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASN 220
                |..::..|:|||::|:||.|||:|..||||::|...|:||.:|..|.|.|||||..:|:|:
  Rat   124 ----HLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSS 184

  Fly   221 RDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPR 285
            .|| :.:|.:..:||||||||.||||.|||.||||:.||||.|.|.||..:|..:..||||||.|
  Rat   185 MDI-SGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSR 248

  Fly   286 PVNVTSNVKLSPTVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIK 350
            |:|:||.|:||.||.|||.|.|..:..|:|.:||||||:|:||.||||::.||::..|::|.|||
  Rat   249 PINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIK 313

  Fly   351 EKLTEDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCD 415
            ||||.|.|.|||||.|:|||.||||||::.:||||.||||||||||:||:||||:||||.|||||
  Rat   314 EKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCD 378

  Fly   416 KPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISD 480
            |.|.|::|:|||.|.|:|...   :|..|||..:||||:.  :||:.::.:
  Rat   379 KKAPYEHLIIDGLFMEILKYC---TDCDEIQFKEDGSWAP--MRSKKEVQE-------------- 424

  Fly   481 DIELISDDAKPVKRDLSPAQDEQPTSTSNS-------ETVDLTLSDSDDDMPLAKRRPPAKQAV- 537
                ::.....|...||...:.|..|.:.|       |.:|||:..|.|:   .:..||||:..
  Rat   425 ----VTASYNGVDGCLSSTLEHQVASHNQSSNKNKKVEVIDLTIDSSSDE---EEEEPPAKRTCP 482

  Fly   538 -ASSTSNGSGGGQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQQQHEQPATAA------ 595
             .|.||..|..|..:.     |.|:....:..|..:.:...::...:|..:|....|..
  Rat   483 SLSPTSPLSNKGILSL-----PHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQG 542

  Fly   596 -------------VHASLLESLAAAVADQKHF-------------QLLDLAAVAAAAAATASSGQ 634
                         .:.|||.:.||||:|.:..             ..||..:...:.:..|::|.
  Rat   543 LDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGS 607

  Fly   635 SQNA 638
            |..:
  Rat   608 SSGS 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	13/33 (39%)
		PINIT	171..307	CDD:291022	77/135 (57%)
		zf-MIZ	368..417	CDD:280964	38/48 (79%)
Pias1	NP_001100299.3	SAP	11..45	CDD:128789	13/33 (39%)
		PINIT	137..285	CDD:405075	82/148 (55%)
		COG5222	<313..428	CDD:227547	71/137 (52%)
		SP-RING_PIAS	332..379	CDD:319704	36/46 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340871
Domainoid	1	1.000	172	1.000	Domainoid score	I3620
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22953
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1890
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205949at2759
OrthoFinder	1	1.000	-	-		FOG0000526
OrthoInspector	1	1.000	-	-		otm44659
orthoMCL	1	0.900	-	-		OOG6_102691
Panther	1	1.100	-	-	O	PTHR10782
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760