DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)2-10 and PIAS3

DIOPT Version :9

Sequence 1:NP_724749.1 Gene:Su(var)2-10 / 35927 FlyBaseID:FBgn0003612 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_006090.2 Gene:PIAS3 / 10401 HGNCID:16861 Length:628 Species:Homo sapiens


Alignment Length:614 Identity:238/614 - (38%)
Similarity:332/614 - (54%) Gaps:92/614 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 ECEQMVQMLRVVELQKILSFLNISFAGRKTDLQSRILSFLRTNLELLAP----KVQEVYAQSVQE 104
            |.:.||...||.|||.:|.|...:.:|||.:|.::.|..|:::   .||    |::|:|.:....
Human     6 ELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSS---CAPSVQMKIKELYRRRFPR 67

  Fly   105 QNATLQYIDPTRMYSHIQLPPTVQP--NPVGLVGSGQGVQVPGGQMNVVGGAPFLHTHSINSQLP 167
            :.     :.|:.: |.:.|||...|  :|..|......:..||   .::|....:..|....| |
Human    68 KT-----LGPSDL-SLLSLPPGTSPVGSPGPLAPIPPTLLAPG---TLLGPKREVDMHPPLPQ-P 122

  Fly   168 IHPDVRLKKLAFYDVLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHA 232
            :||||.:|.|.||:|.|.||:|:||...::||.:|..|.|.|||||..:|.::|::...:|.::.
Human   123 VHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYT 187

  Fly   233 IQVQLRFCLVETSCDQEDCFPPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSP 297
            |||||||||.||||.|||.||||:.||||.|||.||..:|..:...|||||.||:|:|...:||.
Human   188 IQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSA 252

  Fly   298 TVTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLTEDADCEIA 362
            ||.|||.|.|..::.|:|.|:||||::||:..|||:::.||::..|::|.|||||||.|.|.|:|
Human   253 TVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVA 317

  Fly   363 TTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDG 427
            ||.|:|||.||||||::.:||||.||:|||.|||:|||||||:||||.||||||.|.|::|:|||
Human   318 TTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDG 382

  Fly   428 YFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVIS-------DDIELI 485
            .|.|:|.|.   ||..|||..:||||             .|.||.::...:.       |.::  
Human   383 LFMEILSSC---SDCDEIQFMEDGSW-------------CPMKPKKEASEVCPPPGYGLDGLQ-- 429

  Fly   486 SDDAKPVKRDLSPAQDEQPTSTSNS-ETVDLTLSDSDDDMPLAKRRPPAKQ--AVASSTSNGSGG 547
                      .||.|...|:..... |.:|||:..|.|:..|    ||.|:  :|.|:......|
Human   430 ----------YSPVQGGDPSENKKKVEVIDLTIESSSDEEDL----PPTKKHCSVTSAAIPALPG 480

  Fly   548 GQRAYTPAQQPQQSESPEQQASRQSPEKQTVSEQQLQQ-QQHEQPATAAVHASLLESLAAAVADQ 611
            .:...|...||        .:..:||...|:....|.. ..||.|....:.|.:           
Human   481 SKGVLTSGHQP--------SSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADI----------- 526

  Fly   612 KHFQLLDLAAVAAAAAATASSGQSQNAGP 640
               |.|||.:....        :||:.||
Human   527 ---QGLDLFSFLQT--------ESQHYGP 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)2-10NP_724749.1 SAP 49..83 CDD:128789 13/33 (39%)
PINIT 171..307 CDD:291022 73/135 (54%)
zf-MIZ 368..417 CDD:280964 37/48 (77%)
PIAS3NP_006090.2 Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25406032 1..200 73/206 (35%)
SAP 11..>36 CDD:128789 11/24 (46%)
LXXLL motif 19..23 2/3 (67%)
PINIT 126..263 CDD:291022 73/136 (54%)
zf-MIZ 323..371 CDD:280964 36/47 (77%)
SUMO1-binding. /evidence=ECO:0000250 450..460 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..617
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147223
Domainoid 1 1.000 172 1.000 Domainoid score I3725
eggNOG 1 0.900 - - E1_KOG2169
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 396 1.000 Inparanoid score I1966
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1205949at2759
OrthoFinder 1 1.000 - - FOG0000526
OrthoInspector 1 1.000 - - otm40516
orthoMCL 1 0.900 - - OOG6_102691
Panther 1 1.100 - - O PTHR10782
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3884
SonicParanoid 1 1.000 - - X350
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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