DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-10 and zmiz2

DIOPT Version :9

Sequence 1:	NP_724749.1	Gene:	Su(var)2-10 / 35927	FlyBaseID:	FBgn0003612	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_005155538.1	Gene:	zmiz2 / 100333571	ZFINID:	ZDB-GENE-090313-285	Length:	902	Species:	Danio rerio

Alignment Length:	667	Identity:	156/667 - (23%)
Similarity:	231/667 - (34%)	Gaps:	210/667 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NAATSSSPGH----QSTSSAPIAVNPFD-STKYKECEQMVQMLRVVELQKILSFLNISFAGRKTD 74
            :|.:.|.|.|    |..|.|.....|.: |..||:.||                    |.|
Zfish   287 SAPSPSYPTHRMPLQQPSMAQYPAGPGNPSQYYKQAEQ--------------------FNG---- 327

  Fly    75 LQSRILSFLRTNLELLAPKVQEVYAQSVQEQNATLQYIDPTRMYSHIQLPPTVQPNPVGLVGSGQ 139
                                        |..|.:|.....|..||... .|||         :|.
Zfish   328 ----------------------------QGNNHSLSSAVTTGGYSSFN-QPTV---------NGP 354

  Fly   140 GVQVPGGQMNVVGGAPFLHTHSINSQLP-IHPDVRLKKLAFYDVLGTLIKP--STLVPRNTQRVQ 201
            |..:||...:.:.|.| ....:..|.:| :.|:..:|....:||     ||  |.|.|.......
Zfish   355 GRAMPGYPSSPLPGNP-TPPMTPGSSMPYMSPNQDVKSPFLHDV-----KPNISALQPPTGNPSD 413

  Fly   202 EVPFYFTLTPQQATEIASNRD--IRNSSKVEHAIQV-----QLRFCLVETSCDQED------CF- 252
            ::...|.:           ||  :....::||.:.|     |||..:.:|...:.|      |:
Zfish   414 DLRLTFPV-----------RDGVVLEPFRLEHNLAVSNHVFQLRDSVYKTLMMRPDLELQFKCYH 467

  Fly   253 ----------PPNVNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKL------SP---T 298
                      |.:|.|.|                |..|....|..|.||:..|      .|   |
Zfish   468 HEDRQMNTNWPASVQVSV----------------NATPLTIERGDNKTSHKPLYLKHVCQPGRNT 516

  Fly   299 VTNTITVQWCPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGVKPADYTRGLIKEKLT--------- 354
            :..|:|...|     |:...:.||.:.:...:||.:..|.:.||::....||...:
Zfish   517 IQITVTACCC-----SHLFVLQLVHRPSVRSVLQGLMKKRLLPAEHCVTKIKRNFSSGTIPGTPG 576

  Fly   355 ---EDADCEIATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDK 416
               ||.   :..|.:||||.||:...::.||.|...|.|:||||...|||:|..:.||.||||:|
Zfish   577 LNGEDG---VEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCFDLESYLQLNCERGTWRCPVCNK 638

  Fly   417 PAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSWSTPGLRSETQILDTPSKPAQKVEVISDD 481
            .|:.:.|.:|.|...:| ..:..||..||.:....||....::.:..|.:.|..||.|
Zfish   639 TALLEGLEVDQYMLGIL-IYIQNSDYEEITIDPVCSWKPVPVKPDLHIKEDPDGPALK------- 695

  Fly   482 IELISDDAKPVKRDLSPAQDEQPT----------STSNSETVDLTLSDSDDDMPLAKRRPPAKQA 536
                      ..|.|||:....|:          ::|..:::....|.|..|.|.......:.|.
Zfish   696 ----------RCRTLSPSHMILPSVMEMIAALGPASSPYQSLPAGGSSSTPDYPSQGGSGYSSQP 750

  Fly   537 VASSTSNGSGG---GQRAYTPAQQPQQSES--------PEQQASRQSPEKQTVSEQ--------Q 582
            ..|...|..|.   |:  :||...|...:|        ||:......|.:...|.:        |
Zfish   751 GFSDFPNAPGTPTLGE--FTPGPPPLSYQSDLPSGLLTPEKPVGHPMPGQMPHSSRMDPSHNPLQ 813

  Fly   583 LQQQQHEQPATAAVHAS 599
            .|||||:     |:|.|
Zfish   814 QQQQQHQ-----ALHGS 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-10	NP_724749.1	SAP	49..83	CDD:128789	2/33 (6%)
		PINIT	171..307	CDD:291022	35/170 (21%)
		zf-MIZ	368..417	CDD:280964	24/48 (50%)
zmiz2	XP_005155538.1	zf-MIZ	590..638	CDD:280964	24/47 (51%)
zmiz2	XP_005155538.1	ProSAAS	<676..769	CDD:284633	20/111 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000