DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phax and Phax

DIOPT Version :9

Sequence 1:	NP_610456.4	Gene:	Phax / 35926	FlyBaseID:	FBgn0033380	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_064380.3	Gene:	Phax / 56698	MGIID:	1891839	Length:	385	Species:	Mus musculus

Alignment Length:	474	Identity:	124/474 - (26%)
Similarity:	196/474 - (41%)	Gaps:	111/474 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MELHANDVDLEDGELSESDDDGVYTPLQRP-------DGAEKVASPLTTCHQIQTALEDESQSNS 59
            |.|.|.  |:|:|:||:||.|....|..||       .|.....:|::  |.......|.|:.:.
Mouse     1 MALEAG--DMEEGQLSDSDSDMTVVPSDRPLQMAKVLGGGSAACAPVS--HYRTVKHVDSSEESL 61

  Fly    60 DSSTAESSEDGCIKKLRTESTGPDGHKKRKKRIRRTVMRRVP----PTDAEMQPNRARFKKYNVW 120
            |      |:|.|           ...|:::::...|..:..|    |:..:...|..: |..|:|
Mouse    62 D------SDDDC-----------SLWKRKRQKCHNTPPKPEPFPFGPSGQKTALNGGK-KVNNIW 108

  Fly   121 ASALQE---DALSENMRGCDVTRS-GRDRNVENYDFSLRYRLNGENTLKRRLSNSSEDGGECSHP 181
            .:.|||   ||::..:....:..| .|.|..|.|::.|..:| .:...:.......:|..|..|.
Mouse   109 GAVLQEQNQDAVATELGILGMEGSIDRSRQSETYNYLLAKKL-AKKESQEYTKELDKDLDEYMHG 172

  Fly   182 AHKRGRPSSRPITGNQQRGL-VKSRTGHRSRRGTSSASGSSDFCEPRHILDLN-----EVGERD- 239
            ..|.|........|:.:|.. |:.|.|:|                    :::|     |:.|.|
Mouse   173 DKKPGSKEDENGQGHLKRKRPVRDRLGNR--------------------VEMNYKGRYEITEEDA 217

  Fly   240 PSDVATEMASKLYEEKDELLVRVVEVLGIDVCLELYKETQRIEADGGMMIKNGIRRRTPGGVFLF 304
            |..||.|:|.:|.|.|.:|:.|||.:||....:||..||..:|.:||:.|.||.||||||||||.
Mouse   218 PEKVADEIAFRLQEPKKDLIARVVRILGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLN 282

  Fly   305 LIKHHDNITQEQQKRIFSEDRQSLSKSRKQIETLMRDRKVEELKKCLSKQVTELPTLNQRKEYYM 369
            |:|:..:|::||.|.||..:.|...:::|    ..|.|:.:.|.|   |....:.:||     :.
Mouse   283 LLKNTPSISEEQIKDIFYVENQKEYENKK----AARKRRTQLLGK---KMKQAIKSLN-----FQ 335

  Fly   370 QGDEQSEDKQPGSLSNPPPSPVGAEQEHDSPEYRTHEININLVDNAELPSTSKAAAAAQGAPLKD 434
            :.|:.|.:.....                     |:|...:|.:..|.|..:|..|       ::
Mouse   336 EDDDTSRETFASD---------------------TNEALASLDEAQEGPGETKLDA-------EE 372

  Fly   435 LISYDHDFLDVNCGDMDFF 453
            .|..||.      .|:|.|
Mouse   373 AIEVDHP------QDLDIF 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phax	NP_610456.4	RNA_GG_bind	243..326	CDD:287260	41/82 (50%)
Phax	NP_064380.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		12/26 (46%)
		Necessary for interaction with CBP80	2..320		97/339 (29%)
		Nuclear localization signal	71..74		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..101		3/29 (10%)
		Nuclear export signal	120..129		5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..192		5/27 (19%)
		Nuclear localization signal	189..192		0/2 (0%)
		Sufficient for poly U RNA-binding	219..319		44/105 (42%)
		RNA_GG_bind	221..304	CDD:287260	38/88 (43%)
		Necessary for poly U RNA-binding and snRNA export	270..278		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..385		9/49 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842799
Domainoid	1	1.000	80	1.000	Domainoid score	I8608
eggNOG	1	0.900	-	-		E1_KOG3948
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4889
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006484
OrthoInspector	1	1.000	-	-		oto94797
orthoMCL	1	0.900	-	-		OOG6_107898
Panther	1	1.100	-	-	LDO	PTHR13135
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4292
SonicParanoid	1	1.000	-	-		X5458
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780