Protein Alignment Phax and PHAX

DIOPT Version :9

• Sequence 1: NP_610456.4
• Gene: Phax / 35926
• FlyBaseID: FBgn0033380
• Length: 453
• Species: Drosophila melanogaster
• Sequence 2: NP_115553.2
• Gene: PHAX / 51808
• HGNCID: 10241
• Length: 394
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 126/475 - (26%)
• Similarity: 196/475 - (41%)
• Gaps: 118/475 - (24%)

  Fly    10 DLEDGELSESDDDGVYTPLQRPDGAEKV----------ASPLTTCHQIQTALEDESQSNSDSSTA 64
            |:|||:||:||.|....|..||....||          .:..|.|..:......||..:|:.|.:
Human     7 DMEDGQLSDSDSDMTVAPSDRPLQLPKVLGGDSAMRAFQNTATACAPVSHYRAVESVDSSEESFS 71

  Fly    65 ESSEDGCIKKLRTESTGPDGHKKRKKRIRRTVMRRVPPTDAE--------MQPNRARFKKY-NVW 120
            :|.:|.|:.|           :||:|...       ||...|        .:|..|..||. |:|
Human    72 DSDDDSCLWK-----------RKRQKCFN-------PPPKPEPFQFGQSSQKPPVAGGKKINNIW 118

  Fly   121 ASALQE---DALSENM--RGCDVTRSGRDRNVENYDFSLRYRLNGENTLKRRLSNSSEDGGECSH 180
            .:.|||   ||::..:  .|.:.| ..|.|..|.|::.|..:|..|:  :....:..::..|..|
Human   119 GAVLQEQNQDAVATELGILGMEGT-IDRSRQSETYNYLLAKKLRKES--QEHTKDLDKELDEYMH 180

  Fly   181 PAHKRGRPSSRPITGNQQRGL-VKSRTGHRSRRGTSSASGSSDFCEPRHILDLNEVG------ER 238
            ...|.|........|:.:|.. ||.|.|:|.                    ::|..|      |.
Human   181 GGKKMGSKEEENGQGHLKRKRPVKDRLGNRP--------------------EMNYKGRYEITAED 225

  Fly   239 DPSDVATEMASKLYEEKDELLVRVVEVLGIDVCLELYKETQRIEADGGMMIKNGIRRRTPGGVFL 303
            ....||.|::.:|.|.|.:|:.|||.::|....:||..||..:|.:||:.|.||.||||||||||
Human   226 SQEKVADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFL 290

  Fly   304 FLIKHHDNITQEQQKRIFSEDRQSLSKSRKQIETLMRDRKVEELKKCLSKQVTELPTLNQRKEYY 368
            .|:|:..:|::||.|.||..:.|...:::|    ..|.|:.:.|.|   |....:.:||     :
Human   291 NLLKNTPSISEEQIKDIFYIENQKEYENKK----AARKRRTQVLGK---KMKQAIKSLN-----F 343

  Fly   369 MQGDEQSEDKQPGSLSNPPPSPVGAEQEHDSPEYRTHEININLVDNAELPSTSKAAAAAQGAPLK 433
            .:.|:.|.:.....                     |:|...:|.::.|..:.:|..|       :
Human   344 QEDDDTSRETFASD---------------------TNEALASLDESQEGHAEAKLEA-------E 380

  Fly   434 DLISYDHDFLDVNCGDMDFF 453
            :.|..||..      |:|.|
Human   381 EAIEVDHSH------DLDIF 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phax	NP_610456.4	RNA_GG_bind	243..326	CDD:287260	39/82 (48%)
PHAX	NP_115553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		12/25 (48%)
		Necessary for interaction with CBP80. /evidence=ECO:0000250	2..329		107/366 (29%)
		Nuclear localization signal. /evidence=ECO:0000250	81..84		1/13 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..111		8/34 (24%)
		Nuclear export signal. /evidence=ECO:0000250	130..139		0/8 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..211		8/27 (30%)
		Nuclear localization signal. /evidence=ECO:0000250	198..201		1/2 (50%)
		Sufficient for poly U RNA-binding	228..328		43/103 (42%)
		RNA_GG_bind	230..313	CDD:402048	39/82 (48%)
		Necessary for poly U RNA-binding and snRNA export. /evidence=ECO:0000250	279..287		6/7 (86%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152750
Domainoid	1	1.000	78	1.000	Domainoid score	I8822
eggNOG	1	0.900	-	-		E1_KOG3948
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1223195at2759
OrthoFinder	1	1.000	-	-		FOG0006484
OrthoInspector	1	1.000	-	-		oto91215
orthoMCL	1	0.900	-	-		OOG6_107898
Panther	1	1.100	-	-	LDO	PTHR13135
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4292
SonicParanoid	1	1.000	-	-		X5458
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790