DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mys45A and SDAD1

DIOPT Version :9

Sequence 1:	NP_610455.1	Gene:	Mys45A / 35925	FlyBaseID:	FBgn0033379	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_060585.2	Gene:	SDAD1 / 55153	HGNCID:	25537	Length:	687	Species:	Homo sapiens

Alignment Length:	725	Identity:	359/725 - (49%)
Similarity:	486/725 - (67%)	Gaps:	56/725 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRPNNNQLPENLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPSEENKSLDDIVMFVAQ 65
            |...|||:||.|||||||||||||.:|.:||..||.|:.|.:|:|.|.|::.:|.|.::|||:||
Human     1 MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQ 65

  Fly    66 VAQCYPAVCEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPD 130
            ::.|||.....||:.:.|||....|||||.:|..|.|||||||||||:....:|||||:|.||.|
Human    66 ISHCYPEYLSNFPQEVKDLLSCNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELFRCHD 130

  Fly   131 KNLRTFLQTHIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWND 195
            |.||..|.|||||||||:|||||:.|:|..||.|||:||:|:|..|||||.|:|||||::|||||
Human   131 KLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWND 195

  Fly   196 SKTVNVIATVGCFSKVTKVLVTSLKFFLGHDEEDEEEDTDSENEVD---LKGALMANRVNKKTKK 257
            :|||||| |..|||||||:||.:|.||||.| |||::|:|||:|.|   .:..|:.....||:.|
Human   196 AKTVNVI-TTACFSKVTKILVAALTFFLGKD-EDEKQDSDSESEDDGPTARDLLVQYATGKKSSK 258

  Fly   258 RTKQLAQIKKQAVKAQKKKKNAPAFNFSGIHLVHNPQGMAEGLFKQLQATNERFEVKLMHLDVIS 322
            ..|:|.:..| .:|.|||||....||||.|||:|:||..||.|.|||:...||||||:|.:::||
Human   259 NKKKLEKAMK-VLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLECCKERFEVKMMLMNLIS 322

  Fly   323 RLIGIHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNS 387
            ||:|||:||||.|||::.||||||||:||::|.|||||||.|||.:||:.:|.|:||||:|::||
Human   323 RLVGIHELFLFNFYPFLQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNS 387

  Fly   388 SDVMAIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDR 452
            .:||.:|:||.:||..||||||.|:||||||.|||:|:|:|||:||:||.|:|...|.:|.||.|
Human   388 GEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFR 452

  Fly   453 GRQTEAQAERKVRAYGEREVHDTVLGAEALLKDSKTIDIESEDDTDSNDGEWVNVAHSDGEGGGA 517
            |:.|||..|.:|:.|||.:..|.:.|||.|       ::|.|::.::::..|.:.:.|
Human   453 GKPTEASIEARVQEYGELDAKDYIPGAEVL-------EVEKEENAENDEDGWESTSLS------- 503

  Fly   518 DDDEEDEDEDEDDDDEDEDEENSNDEENEDEDNSDEGVESGEESAKAKKEKKDMRILNQKEAAQE 582
                    |:||.|.|..|.::|:|||.::                ..|:...|.:..:|..|..
Human   504 --------EEEDADGEWIDVQHSSDEEQQE----------------ISKKLNSMPMEERKAKAAA 544

  Fly   583 LALTRIFTDEDFKRINAANLKKTVTSA----RKRPL------EQDRAEFVKLNSIEMIYKKRKHD 637
            ::.:|:.|.|||::|..|.::|.:.:|    :||..      |:.|.|.:.|..||.::||.|.|
Human   545 ISTSRVLTQEDFQKIRMAQMRKELDAAPGKSQKRKYIEIDSDEEPRGELLSLRDIERLHKKPKSD 609

  Fly   638 KESRLETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRH--KARSKVKKSFKDKQQA 700
            ||:||.|..||:.||:.|..|..:.|...|.||:||:|.|||.|:|:  ..|||.|:||::||.|
Human   610 KETRLATAMAGKTDRKEFVRKKTKTNPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLA 674

  Fly   701 LRKHLLHQKK 710
            ||..||.::|
Human   675 LRDALLKKRK 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mys45A	NP_610455.1	NUC130_3NT	62..111	CDD:285384	26/48 (54%)
Mys45A	NP_610455.1	SDA1	409..711	CDD:283052	117/314 (37%)
SDAD1	NP_060585.2	NUC130_3NT	62..111	CDD:311883	26/48 (54%)
		SDA1	409..684	CDD:310124	116/312 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..525		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..669		32/64 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157088
Domainoid	1	1.000	356	1.000	Domainoid score	I992
eggNOG	1	0.900	-	-		E1_KOG2229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6036
Inparanoid	1	1.050	663	1.000	Inparanoid score	I768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54075
OrthoDB	1	1.010	-	-		D270594at33208
OrthoFinder	1	1.000	-	-		FOG0003039
OrthoInspector	1	1.000	-	-		oto91417
orthoMCL	1	0.900	-	-		OOG6_102265
Panther	1	1.100	-	-	LDO	PTHR12730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1296
SonicParanoid	1	1.000	-	-		X2028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800