DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mys45A and sdad1

DIOPT Version :9

Sequence 1:	NP_610455.1	Gene:	Mys45A / 35925	FlyBaseID:	FBgn0033379	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_775337.1	Gene:	sdad1 / 286746	ZFINID:	ZDB-GENE-021213-1	Length:	682	Species:	Danio rerio

Alignment Length:	728	Identity:	362/728 - (49%)
Similarity:	489/728 - (67%)	Gaps:	70/728 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NNNQLPENLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPSEENKSLDDIVMFVAQVAQC 69
            :||:||.|||||||||||||:||::||..||:|:.|.:|:|...|.:.||.|.::|||:|||..|
Zfish     5 HNNKLPTNLPQLQNLIKRDPKSYTEEFLQQYRHYQSNVEIFKHQPDKANKDLSELVMFLAQVGHC 69

  Fly    70 YPAVCEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPDKNLR 134
            |.....:||::|:|||.||.|||:..:|..|.||||:||||:||....:|.|||:||||.||.||
Zfish    70 YLEELSDFPQQLTDLLLNYHTVLESDLRMTFCKALIMLRNKDLVSPTSLLGLFFELLRCHDKLLR 134

  Fly   135 TFLQTHIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWNDSKTV 199
            ..|.|||||||||:|||||:.|:.::||.|||:||:|:||.|||:|.|:|:|||::|||||:|||
Zfish   135 KTLYTHIVTDIKNINAKHKNNKMKTTLQNFMYTMLRDSNPIAAKISLDVMVELYRRNIWNDAKTV 199

  Fly   200 NVIATVGCFSKVTKVLVTSLKFFLGHDEEDEEEDTDSENEVD---LKGALMANRVNKKTKKRTKQ 261
            ||| |..|||||||:||..||||||.| |||::|.|||:|.:   .:..:|.....|||.|..|:
Zfish   200 NVI-TTACFSKVTKILVAGLKFFLGKD-EDEKKDDDSESEDEGSTARDLMMRYSTGKKTSKNKKK 262

  Fly   262 LAQIKKQAVKAQKKKKNAPAFNFSGIHLVHNPQGMAEGLFKQLQATNERFEVKLMHLDVISRLIG 326
            |.:..| .:|..||||....||||.|||:|:|:..:|.|.|||:::|||||||:|.:::||||:|
Zfish   263 LEKAMK-VLKKHKKKKKVEVFNFSAIHLIHDPKDFSEKLLKQLESSNERFEVKIMMMELISRLVG 326

  Fly   327 IHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNSSDVM 391
            ||:||||.|||::.||||||||:||::|..|||:||:|||.:||||::.||||||:|:|||.:||
Zfish   327 IHELFLFNFYPFVQRFLQPHQREVTKILLCAAQSSHQLVPPEIIEPVIMTIANNFVTDRNSGEVM 391

  Fly   392 AIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDRGRQT 456
            .:|:||.:|:..||||:|.|||||||..||::|:|:|:|:||.||.|:|:..|.:|.:|||||.|
Zfish   392 TVGINAIKEVVARCPLSMSEDLLQDLTQYKSHKDKNVVMSARGLIQLFRDLNPKMLTRKDRGRPT 456

  Fly   457 EAQAERKVRAYGEREVHDTVLGAEALLKDSKTIDIESED-------DTDSNDGEWVNVAHSDGEG 514
            |:..|.|:..|||.|..|.:.||| :|:..|..|.|.||       ..|..|||||||.||
Zfish   457 ESSKEAKIHKYGELEAKDYIPGAE-VLEAEKAEDEEDEDGWESASMSDDDEDGEWVNVHHS---- 516

  Fly   515 GGADDDEEDEDEDEDDDDEDEDEENSNDEENEDEDNSDEGVESGEESAKAKKEKKDMRILNQKEA 579
                       .|||..:..|..::..:||.                 |||
Zfish   517 -----------SDEDQAEVAEKLQSIPEEER-----------------KAK-------------- 539

  Fly   580 AQELALTRIFTDEDFKRINAANLKKTVTSA----RKRPL----EQDRAEFVKLNSIEMIYKKRKH 636
            |..::.:|:.|.:|||:|..|.:.|.|.:|    :||..    |::|.|.:.|..||.::||.|.
Zfish   540 AAMVSTSRLLTQDDFKKIRVAQMAKEVGNAPGKGQKRKNVDSDEEERGELLSLRDIERLHKKPKS 604

  Fly   637 DKESRLETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRH--KARSKVKKSFKDKQQ 699
            |||:||.|..|||.||:.|..|.|::|.:.|.:|:||::.|||.|:||  ..|:|.|:||::||.
Zfish   605 DKETRLATAMAGRTDRKEFTKKRGKLNPYASTSNKEKKRKKNFMMMRHSQNVRTKGKRSFREKQI 669

  Fly   700 ALRKHLLHQKKMK 712
            |||..||.::|.|
Zfish   670 ALRDSLLKKRKFK 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mys45A	NP_610455.1	NUC130_3NT	62..111	CDD:285384	26/48 (54%)
Mys45A	NP_610455.1	SDA1	409..711	CDD:283052	123/318 (39%)
sdad1	NP_775337.1	NUC130_3NT	62..111	CDD:285384	26/48 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..248		8/21 (38%)
		SDA1	409..680	CDD:283052	123/317 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..545		25/105 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..587		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..682		40/80 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592783
Domainoid	1	1.000	362	1.000	Domainoid score	I905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6036
Inparanoid	1	1.050	673	1.000	Inparanoid score	I707
OMA	1	1.010	-	-		QHG54075
OrthoDB	1	1.010	-	-		D270594at33208
OrthoFinder	1	1.000	-	-		FOG0003039
OrthoInspector	1	1.000	-	-		oto39762
orthoMCL	1	0.900	-	-		OOG6_102265
Panther	1	1.100	-	-	LDO	PTHR12730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1296
SonicParanoid	1	1.000	-	-		X2028
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940