DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mys45A and Sdad1

DIOPT Version :9

Sequence 1:	NP_610455.1	Gene:	Mys45A / 35925	FlyBaseID:	FBgn0033379	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_766301.1	Gene:	Sdad1 / 231452	MGIID:	2140779	Length:	687	Species:	Mus musculus

Alignment Length:	721	Identity:	359/721 - (49%)
Similarity:	485/721 - (67%)	Gaps:	56/721 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NNNQLPENLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPSEENKSLDDIVMFVAQVAQC 69
            |||:||.|||||||||||||.:|.:||..||.|:.|.:|:|.|.|::.:|.|.::|||:||:.||
Mouse     5 NNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNMEIFKLQPNKPSKELAELVMFMAQIGQC 69

  Fly    70 YPAVCEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPDKNLR 134
            ||.....||:.|.|||....|||||.:|..|.|||||||||||:....:|||||:||||.||.||
Mouse    70 YPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLR 134

  Fly   135 TFLQTHIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWNDSKTV 199
            ..|.|||||||||:|||||:.|:|..||.|||:||:|:|..|||||.|:|||||::|||||:|||
Mouse   135 KTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTV 199

  Fly   200 NVIATVGCFSKVTKVLVTSLKFFLGHDEEDEEEDTDSENEVD---LKGALMANRVNKKTKKRTKQ 261
            ||| |..||||:||:||.:|.||||.||| |::|:|||:|.|   .:..|:.....||..|..|:
Mouse   200 NVI-TTACFSKITKILVAALTFFLGKDEE-EKQDSDSESEEDGPTARDLLVQYATGKKGSKNKKK 262

  Fly   262 LAQIKKQAVKAQKKKKNAPAFNFSGIHLVHNPQGMAEGLFKQLQATNERFEVKLMHLDVISRLIG 326
            |.:..| .:|.|||||....||||.|||:|:||..||.|.|||::..||||||:|.:::||||:|
Mouse   263 LEKAMK-VLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESCKERFEVKMMLMNLISRLVG 326

  Fly   327 IHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNSSDVM 391
            ||:||||.|||::.||||||||:||::|.|||||||.|||.:||:.:|.|:||||:|::||.:||
Mouse   327 IHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLVTVANNFVTDKNSGEVM 391

  Fly   392 AIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDRGRQT 456
            .:|:||.:||..||||||.|:||||||.|||:|:|:|||:||:||.|:|...|.:|.||.||:.|
Mouse   392 TVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPT 456

  Fly   457 EAQAERKVRAYGEREVHDTVLGAEALLKDSKTIDIESEDDTDSNDGEWVNVAHSDGEGGGADDDE 521
            ||..|.:::.|||.:..|.:.|||.|       ::|..|:|:.::..|.:.:.|
Mouse   457 EASIEARIQEYGELDAKDYIPGAEVL-------ELEKGDNTEDDEDGWESASLS----------- 503

  Fly   522 EDEDEDEDDDDEDEDEENSNDEENEDEDNSDEGVESGEESAKAKKEKKDMRILNQKEAAQELALT 586
                |:|::|.|..|..:|:|||              :::...|.:...|.  .:|..|..::.:
Mouse   504 ----EEEEEDGEWVDVHHSSDEE--------------QQAIATKLDSMPME--ERKAKAAAISTS 548

  Fly   587 RIFTDEDFKRINAANLKKTVTS----ARKRPL------EQDRAEFVKLNSIEMIYKKRKHDKESR 641
            |:.|.:||::|..|.:||.:.:    |:||..      |:.|.|.:.|..||.::||.|.|||:|
Mouse   549 RVLTQDDFQKIRMAQMKKEMDAAPGKAQKRKYLEIDSDEESRGELLSLRDIERLHKKPKSDKETR 613

  Fly   642 LETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRH--KARSKVKKSFKDKQQALRKH 704
            |.|..|||.||:.|..|..::|...|.||:||:|.|||.|:|:  ..|||..:||::||.|||..
Mouse   614 LATAMAGRTDRKEFVRKKTKINPFSSSTNKEKKKQKNFMMMRYSQNVRSKTARSFREKQLALRDA 678

  Fly   705 LLHQKK 710
            ||.::|
Mouse   679 LLKKRK 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mys45A	NP_610455.1	NUC130_3NT	62..111	CDD:285384	28/48 (58%)
Mys45A	NP_610455.1	SDA1	409..711	CDD:283052	116/314 (37%)
Sdad1	NP_766301.1	NUC130_3NT	62..111	CDD:285384	28/48 (58%)
		SDA1	409..684	CDD:283052	115/312 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..509		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..651		24/46 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847495
Domainoid	1	1.000	356	1.000	Domainoid score	I971
eggNOG	1	0.900	-	-		E1_KOG2229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6036
Inparanoid	1	1.050	659	1.000	Inparanoid score	I760
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54075
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003039
OrthoInspector	1	1.000	-	-		oto94998
orthoMCL	1	0.900	-	-		OOG6_102265
Panther	1	1.100	-	-	LDO	PTHR12730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1296
SonicParanoid	1	1.000	-	-		X2028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790