DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mys45A and pro-3

DIOPT Version :9

Sequence 1:	NP_610455.1	Gene:	Mys45A / 35925	FlyBaseID:	FBgn0033379	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001379304.1	Gene:	pro-3 / 180256	WormBaseID:	WBGene00012676	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	284/778 - (36%)
Similarity:	430/778 - (55%)	Gaps:	101/778 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPS---EENKSLDDIVMFVAQVAQCYPAV 73
            ||..:|.:|::|||||.:||..|:.:|:..:::..|.|.   :|.:||.|.|:|::.:|:.||..
Worm    46 NLGLMQEIIRKDPESYKEEFLEQFNYFVQTMKLLHLQPEQSRQEMQSLVDSVLFLSGLAKHYPKE 110

  Fly    74 CEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPDKNLRTFLQ 138
            .::|...|.:||:.....|||.:|..|.|||:||||::::..:.::|.||:|::..||.||.||.
Worm   111 SKQFSDSLFELLREQGAGLDPEVRMAFCKALVLLRNQDMIDPIILMETFFELVKVEDKVLRKFLL 175

  Fly   139 THIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWNDSKTVNVIA 203
            :.|...:|.:..|.||:|:...:|...:|.:||:....|:.:..:.|:.:::..|.|::|.||||
Worm   176 SSISAHLKRVYHKKKDVKMLGKIQNLCFSKMKDSRSIVARAAQLVCIDAFRRKFWRDARTANVIA 240

  Fly   204 TVGCFSKVTKVLVTSLKFFLGHD------EEDEEEDTDSE-NEVDLKGALMANRVNKKTKKRTKQ 261
            . .||.||.|:.|||:|||||.:      |:.:|.|:|:| |...||..:.:.|..|||:||.|.
Worm   241 Q-ACFHKVAKIQVTSMKFFLGSENENGDAEDSDEMDSDAEDNTKTLKEVMTSFRNVKKTRKREKN 304

  Fly   262 LAQIKKQAVKAQKKKK--NAPAFNFSGIHLVHNPQGMAEGLFKQLQATN-ERFEVKLMHLDVISR 323
            :.:.||...|.:|.||  .:...|...|..:::||...:.||..::|.. :.|||:|..:.:.:|
Worm   305 VERAKKMISKKKKAKKEGRSKECNLMAIQSLYDPQEFVDRLFGAVEAKKMDNFEVRLFKIALCAR 369

  Fly   324 LIGIHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNSS 388
            :||||.|....||.|:.|||||.||.||::|.:||||.||:||.|.:|.:::.|||||:|:|||.
Worm   370 IIGIHRLHTLSFYSYLHRFLQPKQRDVTKILLYAAQACHEMVPPDTVEQLIRVIANNFVTDRNSP 434

  Fly   389 DVMAIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDRG 453
            :.|.:|:||.|||...||.|..|:||:||:.|||||.|:|.|||||||||:|...|.||.:||||
Worm   435 EAMTVGINAIREILSNCPFAATEELLRDLSEYKTYKNKNVSMAARSLITLFRAVNPKLLARKDRG 499

  Fly   454 RQTEAQAE-RKVRAYGEREVHDTVLGAEAL----------------------LKDSKTIDIESED 495
            :..|...| .:...:...:|||.:.|||.|                      :.|..|.|::::|
Worm   500 KPQEKDDEDEEYNGFARPKVHDFISGAEILDEDAADGEQGHLEEDGTDSELDVSDVDTDDVDTDD 564

  Fly   496 DTD--------------SNDGEWVNVAHSDGEGGGADDDEEDEDEDEDDDDEDEDEENSNDEENE 546
            |.|              .||.|      ||.      ||||.|||:|.||:|:|.|.:..:||..
Worm   565 DADEPVAKKKRVEQKSVENDAE------SDA------DDEEIEDEEEMDDEEEEIEISDEEEEEI 617

  Fly   547 DEDNSDEGVESGEESAKAKKEKKDMRILNQKEAAQELALTRIFTDEDFKRINAANLKKTVTS--- 608
            |::..:|.|...|.|...:|:        .|..|.:.::.||.|.||||.|.|..|||.:..
Worm   618 DDEAEEEAVVEEEASEAVEKD--------PKLKASKNSMDRIMTQEDFKNIKAYQLKKQLIGEKR 674

  Fly   609 --------------------ARKRPLEQDRAEFVKLNSIEMIYKKRKHDKESRLETVQAGRQDRE 653
                                |.|..|::......:|:.||..|||::..||.|:..|.|||.|.:
Worm   675 LKKQMGKGRSQADERIVDEMAEKLELKRSSDGLARLSDIEHFYKKKRQSKEERMADVMAGRADED 739

  Fly   654 RFGWKDGRVNE---HCSKTNREKRKTKNFGMLRHKARSKVK-KSFKDKQQALRKHLLHQKKMK 712
               :|.||..:   |..:||.:..|.|.|.|:::|.|.:.: :||:|:|::||.:|:.|...|
Worm   740 ---YKFGRPKKNGAHVGRTNDQNSKKKVFAMVKNKIRGRNRQRSFRDQQKSLRHYLMRQSGRK 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mys45A	NP_610455.1	NUC130_3NT	62..111	CDD:285384	20/48 (42%)
Mys45A	NP_610455.1	SDA1	409..711	CDD:283052	121/365 (33%)
pro-3	NP_001379304.1	NUC130_3NT	99..148	CDD:400466	20/48 (42%)
pro-3	NP_001379304.1	SDA1	456..795	CDD:398789	120/361 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165283
Domainoid	1	1.000	227	1.000	Domainoid score	I1424
eggNOG	1	0.900	-	-		E1_KOG2229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6036
Inparanoid	1	1.050	465	1.000	Inparanoid score	I859
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54075
OrthoDB	1	1.010	-	-		D270594at33208
OrthoFinder	1	1.000	-	-		FOG0003039
OrthoInspector	1	1.000	-	-		oto19061
orthoMCL	1	0.900	-	-		OOG6_102265
Panther	1	1.100	-	-	LDO	PTHR12730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1296
SonicParanoid	1	1.000	-	-		X2028
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800