Protein Alignment tsu and HNRNPDL

DIOPT Version :10

• Sequence 1: NP_610454.2
• Gene: tsu / 35924
• FlyBaseID: FBgn0033378
• Length: 165
• Species: Drosophila melanogaster
• Sequence 2: NP_112740.1
• Gene: HNRNPDL / 9987
• HGNCID: 5037
• Length: 420
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 46/213 - (21%)
• Similarity: 88/213 - (41%)
• Gaps: 59/213 - (27%)

  Fly     1 MADVLDIDNAEEF----------EVDEDGDQGI------------------------VRLKEKAK 31
            |.|:.:..|.|||          ...:||...|                        ..:|....
Human   120 MEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPV 184

  Fly    32 HRKGRGFG----SDSNTREAIHSYERVRNEDDDEL-EPGPQRSVEG----WILFVTSIHEEAQED 87
            ..:.||||    .|:.:.:.:  .|...::.|.:| :|...::::|    ..:||..:..:..|:
Human   185 TGRSRGFGFVLFKDAASVDKV--LELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEE 247

  Fly    88 EIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEY---ETHKQALAAKEALNGAEIMGQTIQVDWC 149
            :|:|.|..:|||:||.|.:|.:|...:|:..:.|   |..|:.|.::....|:   |:      |
Human   248 QIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGS---GK------C 303

  Fly   150 FVK--GPKRVKKSEKRRR 165
            .:|  .||.|.:.:::::
Human   304 EIKVAQPKEVYRQQQQQQ 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tsu	NP_610454.2	PBP2_NikA_DppA_OppA_like	10..>80	CDD:445520	19/112 (17%)
		RRM_RBM8	67..154	CDD:409762	24/95 (25%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..120		46/213 (22%)
		RRM1_hnRPDL	149..224	CDD:410152	11/76 (14%)
		RRM2_hnRPDL	234..308	CDD:409998	23/82 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..348		1/9 (11%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220	342..420
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..420