DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tsu and NCL

DIOPT Version :9

Sequence 1:	NP_610454.2	Gene:	tsu / 35924	FlyBaseID:	FBgn0033378	Length:	165	Species:	Drosophila melanogaster
Sequence 2:	NP_005372.2	Gene:	NCL / 4691	HGNCID:	7667	Length:	710	Species:	Homo sapiens

Alignment Length:	147	Identity:	46/147 - (31%)
Similarity:	72/147 - (48%)	Gaps:	25/147 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EKA--------KHRKGRG-----FGSDSNTREAIHSYERVRNEDDD---ELEPGPQ-----RSVE 71
            |||        ::.|.:|     |.|..:.:||::|..:...|...   ||: ||:     ||..
Human   507 EKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQ-GPRGSPNARSQP 570

  Fly    72 GWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEALNG 136
            ...|||..:.|:..|:.::|.|  .|.:: ..:..||.||.|||:..|::.:.:.|.|||||:..
Human   571 SKTLFVKGLSEDTTEETLKESF--DGSVR-ARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMED 632

  Fly   137 AEIMGQTIQVDWCFVKG 153
            .||.|..:.:||...||
Human   633 GEIDGNKVTLDWAKPKG 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsu	NP_610454.2	PBP2_NikA_DppA_OppA_like	10..>80	CDD:413028	20/72 (28%)
tsu	NP_610454.2	RRM_RBM8	67..154	CDD:409762	31/92 (34%)
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..303
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	307..381	CDD:240849
		RRM	379..628	CDD:223796	36/124 (29%)
		RRM2_NCL	390..465	CDD:240850
		RRM3_NCL	485..557	CDD:240851	11/49 (22%)
		RRM4_NCL	572..649	CDD:240852	27/79 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..710		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910