Protein Alignment Pgm2a and PRM15

DIOPT Version :10

• Sequence 1: NP_610453.1
• Gene: Pgm2a / 35923
• FlyBaseID: FBgn0033377
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_014005.1
• Gene: PRM15 / 855321
• SGDID: S000004891
• Length: 622
• Species: Saccharomyces cerevisiae
• Alignment Length: 620
• Identity: 241/620 - (38%)
• Similarity: 352/620 - (56%)
• Gaps: 42/620 - (6%)

  Fly    22 ELDGEIRKWIRWDKCASTACQIMDAVRAKDWDTLRKRLCTRISFGTAGLRACMRAGFDSMNELVV 86
            :|...|..|.:.|:...|..::....:..||:.|.||..:||.|||||||:.|:|||..||.|||
Yeast    12 DLKDPISLWFKQDRNPKTIEEVTALCKKSDWNELHKRFDSRIQFGTAGLRSQMQAGFSRMNTLVV 76

  Fly    87 IQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGRYNSHRFAELSAIVFLNNDFKVWLFK---RYVA 148
            ||.:|||..|:::|:||     ....|.|:|.|::|..||..:|..||...|||....   .:|.
Yeast    77 IQASQGLATYVRQQFPD-----NLVAVVGHDHRFHSKEFARATAAAFLLKGFKVHYLNPDHEFVH 136

  Fly   149 TPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTNGAQIIPPHDEGIQESILNNLEPKGSSWD 213
            ||:||||:.:|:...|||:|||||||.|||||||::||.|||||||..|.:||..||||..:.||
Yeast   137 TPLVPFAVDKLKASVGVMITASHNPKMDNGYKVYYSNGCQIIPPHDHAISDSIDANLEPWANVWD 201

  Fly   214 -----DSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEANGRCSLSFTYTAMHGVGY----AF 269
                 :.|:....::....:::.....::.|..:....|:...:....|.||.|||||:    ..
Yeast   202 FDDVLNKALKQGKLMYSREEMLKLYLEEVSKNLVEINPLKLEVKAKPWFVYTPMHGVGFDIFSTI 266

  Fly   270 VKQAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIKTAKANSSQIILANDPDADR 334
            ||:....:..|.::.|.|||.|||.|||...||||| |.:||:.|..|:.:...:::||||||||
Yeast   267 VKKTLCLVEGKDYLCVPEQQNPDPSFPTVGFPNPEE-KGALDIGINLAEKHDIDLLVANDPDADR 330

  Fly   335 LAVA-EVREDGSYKLFSGNEVGALLGWWSLELHKMREPDCD-VSNCVMIASTVSSKILRAMAERE 397
            .:|| :..:.|.::..:|||:|.|..::..:.:|..:.:.. |....|:.|||||::::.|||.|
Yeast   331 FSVAVKDMQSGEWRQLTGNEIGFLFAFYEYQKYKSMDKEFQHVHPLAMLNSTVSSQMIKKMAEIE 395

  Fly   398 GFQFFETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDKDGVSAAGHLATMACYLRC 462
            ||.:.:|||||||:||:||.|::.|..|.|.||||||:|......||||:||:  :..:..|.:.
Yeast   396 GFHYEDTLTGFKWIGNRAILLEKKGYYVPFGFEEAIGYMFPAMEHDKDGISAS--IVFLQAYCKW 458

  Fly   463 KLCMTLQ--EKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLRTWDEGKADTYPTSILNGEYE 525
            |:...|.  ..|.:.::.||.....:.|.:...|.|.:.||:.:|.....:..:||:|| ..|.|
Yeast   459 KIDHNLDPLNVLENGFKKYGVFKEYNGYYVVPNPTVTKDIFDYIRNVYTPEGASYPSSI-GEEIE 522

  Fly   526 IENVRDLTTGFDSSTGDKKATLPTSSSSQMITFTFK--NG-----LVVTLRTSGTEPKMKYYAEM 583
            :...||||||:.|.|.:.|.|||...:|||||.:.:  ||     :..|:|.||||||:|.|.|.
Yeast   523 VLYYRDLTTGYQSDTINHKPTLPVDPTSQMITVSARPSNGSENEHIRFTIRGSGTEPKLKVYIEA 587

  Fly   584 CGKPDEKN--WAKLT-NTMNTMVEAIVEEFYEPSK 615
            |...:::.  .|||| |.:.       .|::.|.:
Yeast   588 CANEEQRASFLAKLTWNVLR-------REWFRPDE 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	241/619 (39%)
PRM15	NP_014005.1	PGM2	52..596	CDD:100092	224/552 (41%)