DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2a and Pgm2l1

DIOPT Version :9

Sequence 1:	NP_610453.1	Gene:	Pgm2a / 35923	FlyBaseID:	FBgn0033377	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001102924.1	Gene:	Pgm2l1 / 685076	RGDID:	1583226	Length:	621	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	305/608 - (50%)
Similarity:	419/608 - (68%)	Gaps:	16/608 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSGDPELDGEIRKWIRWDKCASTACQIMDAVRAKDWDTLRKRLCTRISFGTAGLRACMRAGFDSM 81
            |:|||:||..|.:|:||||...|..||.:.:|......||.|||.|::|||||||:.|.|||..:
  Rat    19 LTGDPQLDTAIGQWLRWDKNPKTKEQIENLLRNGMNKELRDRLCCRMTFGTAGLRSAMGAGFCYI 83

  Fly    82 NELVVIQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGR------YNSHRFAELSAIVFLNNDFKV 140
            |:|.|||:.||:.:|::..:   :|:..||.|.|||.|      .:|.|.|:|:|.|.|..|..|
  Rat    84 NDLTVIQSTQGMYKYLERCF---SDFKQRGFVVGYDTRGQVTSSCSSQRLAKLTAAVLLAKDVPV 145

  Fly   141 WLFKRYVATPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTNGAQIIPPHDEGIQESILNNL 205
            :||.|||.||.||:|:..|:.:||||:|||||.||||||||||..||||..|||:.|.:.|...:
  Rat   146 YLFSRYVPTPFVPYAVQELKAVAGVMITASHNRKEDNGYKVYWETGAQITSPHDKEILKCIEECV 210

  Fly   206 EPKGSSWDDSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEANGRCSLSFTYTAMHGVGYAFV 270
            ||...||:|:.:.::.:.:||...:...|.:.|||  .|...:.|.:.:|.|.:|:.||||:.:|
  Rat   211 EPWDDSWNDNLVDTSPLKKDPLQDICRRYMEDLKK--ICFYRDLNSKTTLKFVHTSFHGVGHDYV 273

  Fly   271 KQAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIKTAKANSSQIILANDPDADRL 335
            :.||.....||.|.|.||::|||:|.|...||||||::.|:||::.|:..:::|:||.|||||||
  Rat   274 QLAFQVFGFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLRLAEKENARIVLATDPDADRL 338

  Fly   336 AVAEVREDGSYKLFSGNEVGALLGWWSLELHKMREPDCDVSNCVMIASTVSSKILRAMAEREGFQ 400
            ||||::|:|.:|:|:|||:.||.|||..:..|..:|:.||.|..|:|:|||||||:|:|.:|||.
  Rat   339 AVAELQENGHWKVFTGNELAALFGWWMFDCWKKSKPNADVKNVYMLATTVSSKILKAIALKEGFH 403

  Fly   401 FFETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDKDGVSAAGHLATMACYLRCKLC 465
            |.|||.||||:|::..:|...||.|||||||:|||:.||:||||||||||..:|.||.:|..:.
  Rat   404 FEETLPGFKWIGSRIKDLLGHGKEVLFAFEESIGFLCGTSVLDKDGVSAAVVVAEMAAFLDARK- 467

  Fly   466 MTLQEKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLRTWDEGKADTYPTSILNGEYEIENVR 530
            :||.|:|..:|||||:|.:.:||.:|..||.|:.||||:|.::..|  .||.  ..|.:.|.:||
  Rat   468 VTLMEQLMKVYETYGYHMSKTSYFLCYDPPTIKTIFERIRNFESPK--EYPK--FCGAFAILHVR 528

  Fly   531 DLTTGFDSSTGDKKATLPTSSSSQMITFTFKNGLVVTLRTSGTEPKMKYYAEMCGKPDEKNWAKL 595
            |:|||:|||..:||:.||.|.:||||||||:||.|.||||||||||:|||||||..|.:.:.|.|
  Rat   529 DITTGYDSSQPNKKSVLPVSKNSQMITFTFQNGCVATLRTSGTEPKIKYYAEMCASPGQSDTALL 593

  Fly   596 TNTMNTMVEAIVEEFYEPSKNGL 618
            ...:..:::|::|.|.|||||||
  Rat   594 EEELKKLIDALIENFLEPSKNGL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	301/602 (50%)
Pgm2a	NP_610453.1	PGM2	62..604	CDD:100092	274/547 (50%)
Pgm2l1	NP_001102924.1	PTZ00150	24..620	CDD:240294	301/603 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4186
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I956
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm9036
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840