DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgm2a and Pgm2

DIOPT Version :9

Sequence 1:	NP_610453.1	Gene:	Pgm2a / 35923	FlyBaseID:	FBgn0033377	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001099477.2	Gene:	Pgm2 / 289632	RGDID:	1306061	Length:	620	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	304/615 - (49%)
Similarity:	404/615 - (65%)	Gaps:	19/615 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSGDPELDGEIRKWIRWDKCASTACQIMDAVRAKDWDTLRKRLCTRISFGTAGLRACMRAGFDSM 81
            |..|..||.|..:|:|||:...|:..:...:...:.:.|.|....|:.||||||||.|.||...|
  Rat    17 LGMDARLDQETAQWLRWDRNPLTSESVKQLLAEGNKEELEKCFGARMEFGTAGLRAPMGAGISRM 81

  Fly    82 NELVVIQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGRY------NSHRFAELSAIVFLNNDFKV 140
            |:|.:|||.||.|.|:::|:   :|...||:|..:|||.      :|.|||.|:|..|::....|
  Rat    82 NDLTIIQTTQGFCRYLEKQF---SDLKQRGVVISFDGRAHPASGGSSRRFARLAATAFISQGVPV 143

  Fly   141 WLFKRYVATPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTNGAQIIPPHDEGIQESILNNL 205
            .||.....||.||:.:..|:..||:|:|||||||:||||||||.||||||.|||.||.::|..||
  Rat   144 HLFSDITPTPFVPYTVSHLKLCAGIMITASHNPKQDNGYKVYWDNGAQIISPHDRGISQAIEENL 208

  Fly   206 EPKGSSWDDSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEANGRCSLSFTYTAMHGVGYAFV 270
            ||...:||:|.:.|:::|.:|...:...||:.|||.  |.....|....:.|.:|::||||:.||
  Rat   209 EPWPQAWDESLIDSSSLLHNPSTSISNDYFEDLKKY--CFHRTVNRESQVKFVHTSVHGVGHEFV 271

  Fly   271 KQAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIKTAKANSSQIILANDPDADRL 335
            :.||...:|.|..:|.:|::|||||||...|||||||..|.||.:.|....::|:||||||||||
  Rat   272 QSAFKAFDLNPPEAVPQQKDPDPEFPTVKYPNPEEGKGVLTLSFELADKIKAKIVLANDPDADRL 336

  Fly   336 AVAEVREDGSYKLFSGNEVGALLGWWSLELHKMR-EPDCDVSNCVMIASTVSSKILRAMAEREGF 399
            ||||.::.|.:::|||||:|||||||.....|.: :...::.:..|::||||||||||:|.:|||
  Rat   337 AVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQGQSNLKDTYMLSSTVSSKILRAIALKEGF 401

  Fly   400 QFFETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDKDGVSAAGHLATMACYLRCK- 463
            .|.|||||||||||:|.:|...|||||||||||||:|....||||||||||...|.:..:|..|
  Rat   402 HFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVISAELVSFLATKN 466

  Fly   464 LCMTLQEKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLRTWDEGKADTYPTSILNGEYEIEN 528
            |.::||  |:.||..||:|.|.:||.||.....|:::||.||.:| || :.||.:.  |::||..
  Rat   467 LSLSLQ--LKAIYLEYGYHITTASYFICHDQGTIQKLFENLRNYD-GK-NKYPKTC--GKFEISA 525

  Fly   529 VRDLTTGFDSSTGDKKATLPTSSSSQMITFTFKNGLVVTLRTSGTEPKMKYYAEMCGKPDEKNWA 593
            |||||||:||:..||||.||||.|||||||||.||.|.|:||||||||:|||||:|..|...:..
  Rat   526 VRDLTTGYDSNQPDKKAVLPTSKSSQMITFTFVNGGVATMRTSGTEPKIKYYAELCAPPGNSDPE 590

  Fly   594 KLTNTMNTMVEAIVEEFYEPSKNGLQRRKE 623
            :|...::.:|.||.|.|::|.|..||.:.|
  Rat   591 QLKRELDELVGAIEEHFFQPQKYNLQPKAE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	301/607 (50%)
Pgm2a	NP_610453.1	PGM2	62..604	CDD:100092	282/549 (51%)
Pgm2	NP_001099477.2	PTZ00150	19..620	CDD:240294	302/611 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4186
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	589	1.000	Inparanoid score	I956
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm9036
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	LDO	PTHR45745
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840