Protein Alignment Pgm2a and PGM2L1

DIOPT Version :9

• Sequence 1: NP_610453.1
• Gene: Pgm2a / 35923
• FlyBaseID: FBgn0033377
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_011543255.1
• Gene: PGM2L1 / 283209
• HGNCID: 20898
• Length: 643
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 305/629 - (48%)
• Similarity: 420/629 - (66%)
• Gaps: 38/629 - (6%)

  Fly    18 SGDPELDGEIRKWIRWDK-----------------C----ASTACQIMDAVRAKDWDTLRKRLCT 61
            :|||:||..|.:|:||||                 |    ..|..||.:.:|......||.|||.
Human    20 TGDPQLDTAIGQWLRWDKLQGRLAWCPGRRVEHDSCFLQNPKTKEQIENLLRNGMNKELRDRLCC 84

  Fly    62 RISFGTAGLRACMRAGFDSMNELVVIQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGR------Y 120
            |::|||||||:.|.|||..:|:|.|||:.||:.:|::..:   :|:..||.|.|||.|      .
Human    85 RMTFGTAGLRSAMGAGFCYINDLTVIQSTQGMYKYLERCF---SDFKQRGFVVGYDTRGQVTSSC 146

  Fly   121 NSHRFAELSAIVFLNNDFKVWLFKRYVATPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTN 185
            :|.|.|:|:|.|.|..|..|:||.|||.||.||:|:.:|:.:||||:|||||.||||||||||..
Human   147 SSQRLAKLTAAVLLAKDVPVYLFSRYVPTPFVPYAVQKLKAVAGVMITASHNRKEDNGYKVYWET 211

  Fly   186 GAQIIPPHDEGIQESILNNLEPKGSSWDDSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEAN 250
            ||||..|||:.|.:.|...:||...||:|:.:.::.:..||...:...|.:.|||  .|...|.|
Human   212 GAQITSPHDKEILKCIEECVEPWNGSWNDNLVDTSPLKRDPLQDICRRYMEDLKK--ICFYRELN 274

  Fly   251 GRCSLSFTYTAMHGVGYAFVKQAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIK 315
            .:.:|.|.:|:.||||:.:|:.||.....||.|.|.||::|||:|.|...||||||::.|:||::
Human   275 SKTTLKFVHTSFHGVGHDYVQLAFKVFGFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLR 339

  Fly   316 TAKANSSQIILANDPDADRLAVAEVREDGSYKLFSGNEVGALLGWWSLEL-HKMREPDCDVSNCV 379
            .|:..:::::||.||||||||.||::|:|.:|:|:|||:.||.|||..:. .|.:..:.||.|..
Human   340 LAEKENARVVLATDPDADRLAAAELQENGCWKVFTGNELAALFGWWMFDCWKKNKSRNADVKNVY 404

  Fly   380 MIASTVSSKILRAMAEREGFQFFETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDK 444
            |:|:|||||||:|:|.:|||.|.|||.||||:|::.|:|.:.||.|||||||:|||:.||:||||
Human   405 MLATTVSSKILKAIALKEGFHFEETLPGFKWIGSRIIDLLENGKEVLFAFEESIGFLCGTSVLDK 469

  Fly   445 DGVSAAGHLATMACYLRCKLCMTLQEKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLRTWDE 509
            ||||||..:|.||.||. .:.:||:::|..:||.||:|.:.:||.:|..||.|:.||||||.:|.
Human   470 DGVSAAVVVAEMASYLE-TMNITLKQQLVKVYEKYGYHISKTSYFLCYEPPTIKSIFERLRNFDS 533

  Fly   510 GKADTYPTSILNGEYEIENVRDLTTGFDSSTGDKKATLPTSSSSQMITFTFKNGLVVTLRTSGTE 574
            .|  .||.  ..|.:.|.:|||:|||:|||..:||:.||.|.:||||||||:||.|.||||||||
Human   534 PK--EYPK--FCGTFAILHVRDVTTGYDSSQPNKKSVLPVSKNSQMITFTFQNGCVATLRTSGTE 594

  Fly   575 PKMKYYAEMCGKPDEKNWAKLTNTMNTMVEAIVEEFYEPSKNGL 618
            ||:|||||||..||:.:.|.|...:..:::|::|.|.:||||||
Human   595 PKIKYYAEMCASPDQSDTALLEEELKKLIDALIENFLQPSKNGL 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	302/624 (48%)
		PGM2	62..604	CDD:100092	275/548 (50%)
PGM2L1	XP_011543255.1	PTZ00150	24..642	CDD:240294	302/625 (48%)
		PGM2	85..628	CDD:100092	276/552 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4282
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I1003
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S1166
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm8561
orthoMCL	1	0.900	-	-		OOG6_100912
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R913
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820