DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgm2a and pgm2l1

DIOPT Version :9

Sequence 1:	NP_610453.1	Gene:	Pgm2a / 35923	FlyBaseID:	FBgn0033377	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_002943713.3	Gene:	pgm2l1 / 100496817	XenbaseID:	XB-GENE-6076458	Length:	642	Species:	Xenopus tropicalis

Alignment Length:	625	Identity:	304/625 - (48%)
Similarity:	414/625 - (66%)	Gaps:	17/625 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCQSGGQMLCEIKNMALSGDPELDGEIRKWIRWDKCASTACQIMDAVRAKDWDTLRKRLCTRISF 65
            |.::||.:...:...:.:|:||||..:.:|:||||...|..||...:|......||:|||.|:||
Frog    23 MGETGGDVNSNLLIPSSTGEPELDLAVWQWLRWDKNPKTKAQIETLLRNGKNKELRERLCCRMSF 87

  Fly    66 GTAGLRACMRAGFDSMNELVVIQTAQGLCEYIKEQYPDPADWSGRGIVFGYDGR------YNSHR 124
            ||||||:.|.|||..:|:|.:|||:||:..|::..:|   |...||:|.|||.|      .:|.|
Frog    88 GTAGLRSAMGAGFSCINDLTIIQTSQGMYHYLERSFP---DLKKRGLVIGYDTRGQVTSNSSSIR 149

  Fly   125 FAELSAIVFLNNDFKVWLFKRYVATPMVPFAILRLQCLAGVMVTASHNPKEDNGYKVYWTNGAQI 189
            ||:|||.|||:....|.||.|||.||.||:|:.:|..:||||||||||.|||||:||||.|||||
Frog   150 FAKLSAAVFLSRGVPVQLFSRYVPTPFVPYAVQKLGAVAGVMVTASHNRKEDNGFKVYWENGAQI 214

  Fly   190 IPPHDEGIQESILNNLEPKGSSWDDSAMCSNTMLEDPYDIVVPPYFDILKKQLPCTSLEANGRCS 254
            ..|||:.|.:.|..:.||...||.::...|:.:..||.:.:...|.:.|  |..|.....|.:..
Frog   215 TSPHDKEILKCIEQHAEPWDESWQENLPDSSPLARDPLEEITRSYMEEL--QSLCFHRHINMKTP 277

  Fly   255 LSFTYTAMHGVGYAFVKQAFARINLKPFISVCEQQEPDPEFPTTPMPNPEEGKTSLDLSIKTAKA 319
            |.|.:::.||||:.:|:.||......|.|.|.||::|||:|.|...||||||:..|:||::.|:.
Frog   278 LKFVHSSFHGVGHDYVQGAFRVFGFSPPIPVPEQKDPDPDFSTVKCPNPEEGECVLELSLRLAEK 342

  Fly   320 NSSQIILANDPDADRLAVAEVREDGSYKLFSGNEVGALLGWWSLELHKMREPD-CDVSNCVMIAS 383
            ..:::::|.|||||||||||:::.|.:|:|:|||:.||||||.........|| .||.:..|:|:
Frog   343 EGARVVVATDPDADRLAVAELQDMGRWKVFTGNELAALLGWWMFYCWDKSCPDRSDVRDVCMLAT 407

  Fly   384 TVSSKILRAMAEREGFQFFETLTGFKWMGNKAIELQQAGKTVLFAFEEAIGFMVGTTVLDKDGVS 448
            ||||.||||:|.:|||.|.|||.||||:||:...|...||||:|||||:||||.||:|.||||||
Frog   408 TVSSSILRAIANKEGFHFEETLPGFKWIGNRVKSLLDEGKTVVFAFEESIGFMCGTSVPDKDGVS 472

  Fly   449 AAGHLATMACYLRCKLCMTLQEKLRDIYETYGFHTTVSSYVICRCPPVIEQIFERLRTWDEGKAD 513
            ||..:|.||.:|... .:|::::|..:|||||:|.:.:||.:|..|..|.:||||||.::..|
Frog   473 AAVVVAEMAAFLDSN-NVTMEQQLESLYETYGYHISKTSYFLCYDPATIRRIFERLRNYNGPK-- 534

  Fly   514 TYPTSILNGEYEIENVRDLTTGFDSSTGDKKATLPTSSSSQMITFTFKNGLVVTLRTSGTEPKMK 578
            .||.  ..|.|.|.:|||:|||:|||..:||:.||.|.||||:||:|:||.|.||||||||||:|
Frog   535 RYPE--FCGPYGILHVRDVTTGYDSSQLNKKSVLPVSKSSQMVTFSFQNGCVATLRTSGTEPKIK 597

  Fly   579 YYAEMCGKPDEKNWAKLTNTMNTMVEAIVEEFYEPSKNGL 618
            |||||||.|.:...:.|...:..:::|:||.|.|||:|||
Frog   598 YYAEMCGTPGQGEKSFLEEELKKVIDALVENFLEPSRNGL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgm2a	NP_610453.1	PTZ00150	23..623	CDD:240294	298/603 (49%)
Pgm2a	NP_610453.1	PGM2	62..604	CDD:100092	272/548 (50%)
pgm2l1	XP_002943713.3	PTZ00150	45..638	CDD:240294	298/603 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4031
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I997
OMA	1	1.010	-	-		QHG53730
OrthoDB	1	1.010	-	-		D1041556at2759
OrthoFinder	1	1.000	-	-		FOG0002126
OrthoInspector	1	1.000	-	-		mtm9452
Panther	1	1.100	-	-	O	PTHR45745
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1578
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080