Protein Alignment Vang and Vangl1

DIOPT Version :10

• Sequence 1: NP_001260819.1
• Gene: Vang / 35922
• FlyBaseID: FBgn0015838
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_006233116.1
• Gene: Vangl1 / 690366
• RGDID: 1597324
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 602
• Identity: 259/602 - (43%)
• Similarity: 361/602 - (59%)
• Gaps: 84/602 - (13%)

  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGF 65
            |:.||..|.:|..|..|:..                      ||:.:|:|..|:|.. :|..:|.
  Rat     1 MDTESTYSGYSYYSSHSKKS----------------------HRQGERTRERHKSPR-NKDGRGS 42

  Fly    66 QRG--DMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMEDINNMWH 128
            ::.  ..||....: :..|.:|.|.|.:      ||:||||.|||:|| |||.|||.|||..: .
  Rat    43 EKSVTIQAPTGEPL-LANDSAHTGTEEV------QDDNWGETTTAITG-TSEHSISQEDIARI-S 98

  Fly   129 RESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQLLACSE 193
            ::.:......|:||:..:....||...|.:|:|.:::|.:.:              |.:|..|..
  Rat    99 KDMEDSVGLDCKRYLGLTIASFLGLLVFLTPIAFILLPQILW--------------REELKPCGA 149

  Fly   194 QCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIVQVTNGA 258
            .|:|.|:|::.:||:|.||.||:|.|:..|.:||:|::|||:|:|:.:...:|||||      |.
  Rat   150 ICEGLLISVSFKLLILLIGTWALFFRKQRADVPRVFVFRALLLVLIFLFVVSYWLFY------GV 208

  Fly   259 KIVVETGGDAVD--YKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVSRSYM 321
            :|:     |:.|  ||.:|.||.:.||.||||||:|:||||||..||.:.::::||.||.||.|.
  Rat   209 RIL-----DSRDQNYKDIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYS 268

  Fly   322 LGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEV------------- 373
            ||.|||||||:.||::||.||.|:||.|    ::.||.:..|.....|.|.|
  Rat   269 LGHLSIQRAALVVLENYYKDFTIYNPNL----LTASKFRAAKHMAGLKVYNVDAALMAKLKLCVA 329

  Fly   374 DGVSNSQQQSQSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNE 438
            ||.||: ...||||::||.||||||||||.:|||.|:|||||||||||:.|.||||.||:|:..|
  Rat   330 DGPSNN-ATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRRARLVVAVEEAFIHIQRLQAE 393

  Fly   439 ---PAPALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEP 500
               .:|...:||:|||.|:|||||||||||||.||||..|:.||||:|||.|:.:.::|:||||.
  Rat   394 EQQKSPGEVMDPREAAQAIFPSMARALQKYLRTTRQQHYHSMESILQHLAFCITNSMTPKAFLER 458

  Fly   501 YLTESPVMQSEKERRWVQS-WSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVV 564
            ||:..|.:|.:|: ||:.: |.||.||.|:..:.:...|.|...|.||:|.|.|:|...|:||.:
  Rat   459 YLSAGPTLQYDKD-RWLSTQWRLISDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIVLSEEFI 522

  Fly   565 DPKSNKFVLKLNSETSV 581
            ||||:||||:|.|||||
  Rat   523 DPKSHKFVLRLQSETSV 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	43..581	CDD:461971	250/558 (45%)
Vangl1	XP_006233116.1	Strabismus	25..539	CDD:461971	248/554 (45%)