DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vang and vangl2

DIOPT Version :9

Sequence 1:	NP_001260819.1	Gene:	Vang / 35922	FlyBaseID:	FBgn0015838	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001027481.1	Gene:	vangl2 / 613073	XenbaseID:	XB-GENE-973460	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	255/595 - (42%)
Similarity:	352/595 - (59%)	Gaps:	88/595 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENESVKSEH---SGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSA 62
            |:|:|..|.:   ||.||.||.|                         |||     |..|.|||.
Frog     1 MDNDSQYSGYSYKSGHSRSSRKH-------------------------RDR-----RERHRSKSR 35

  Fly    63 KGFQRGDMAPYQTSVNMTGDG-------SHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISM 120
            :| .|||     .||.:...|       |..|::        :|:||||.||.||| |||.|||.
Frog    36 EG-SRGD-----KSVTIQAPGEPLLDNESTRGED--------RDDNWGETTTVVTG-TSEHSISH 85

  Fly   121 EDINNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVR 185
            :||..: .::.:......|.|::.......|...:|.:|:|.:::|.:.:              |
Frog    86 DDITRI-TKDMEDSAKLDCSRHLGVVIGGALALLSFLTPIAFMLLPQILW--------------R 135

  Fly   186 TQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFY 250
            ..|..|...|:|..:|:|.:||:|.:|.||:|.||..|..||:|::|||:::||.:...:|||||
Frog   136 EDLEQCGTACEGLFISVAFKLLILLLGSWALFFRRPKAFFPRVFVFRALLMVLVFLLVVSYWLFY 200

  Fly   251 IVQVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDG 315
            .|::.....         .:|:.:|.||.:.||.|||:||:||||||||..||.:.:|::||.||
Frog   201 GVRILESRD---------KNYQGIVQYAVSLVDALLFVHYLAVVLLELRQLQPQFTVKVVRSTDG 256

  Fly   316 VSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQ 380
            .||.|.:|.|||||.|||:|::||.|||::||.|..:|    ||..:|..:.||.|.: |..|:.
Frog   257 ASRFYNIGHLSIQRVAVWILENYYHDFPVYNPALLNLP----KSILSKKMSGFKVYSL-GEENTT 316

  Fly   381 QQS--QSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPA--P 441
            ..|  |||||:||.|||||:||||.:|||.|:||||:||:|||:.|.|||||||||:.:|..  |
Frog   317 NNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRKARLVVAVEEAFTHIKRLQDEDQKNP 381

  Fly   442 ALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESP 506
            ...:||:|||.|:|.|||||:|||||.|:|||.||.||||.||..|:.||::|:||||.||...|
Frog   382 REIMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILHHLEFCITHDMTPKAFLERYLGPGP 446

  Fly   507 VMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKF 571
            .:|..|:|...:.|:|:.:|.|:..:.:...|.|.:.|.||:|:..|:|.|.|:||.|||||:||
Frog   447 TIQYHKDRWLAKQWTLVSEEPVTNGLKDGVVFVLKRQDFSLVVSTKKIPFFKLSEEFVDPKSHKF 511

  Fly   572 VLKLNSETSV 581
            |::|.|||||
Frog   512 VMRLQSETSV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	44..581	CDD:284135	242/547 (44%)
vangl2	NP_001027481.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		40/124 (32%)
		Strabismus	24..521	CDD:369014	242/545 (44%)
		PDZ-binding. /evidence=ECO:0000255	518..521		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I606
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1685
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		oto104256
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110