DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vang and vangl1

DIOPT Version :9

Sequence 1:	NP_001260819.1	Gene:	Vang / 35922	FlyBaseID:	FBgn0015838	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_991313.1	Gene:	vangl1 / 403076	ZFINID:	ZDB-GENE-040621-2	Length:	527	Species:	Danio rerio

Alignment Length:	597	Identity:	244/597 - (40%)
Similarity:	342/597 - (57%)	Gaps:	86/597 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRER-DRSRHS-HRSTHSSKSAK 63
            |:.:|:.|.:|..|.|||..|...                    || .|.||. |....||:|.|
Zfish     1 MDTDSIHSGYSHHSNRSRGSNKQS--------------------ERSSRDRHKPHSRDSSSRSDK 45

  Fly    64 GF---------QRGDMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSIS 119
            ..         |:.|.:...|..                    ||:||||.|||||| ||:.|:|
Zfish    46 NVTISATSVQPQQPDQSSAPTDA--------------------QDDNWGETTTAVTG-TSDHSLS 89

  Fly   120 MEDINNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTV 184
            .||:...............|.|::..:...|||.....:|::.:::|.:.:       ||..||
Zfish    90 QEDLAGFGKDTEGPVEKLNCIRFLPLALTLLLGLLVLVTPLSFLILPQLMW-------PERLQT- 146

  Fly   185 RTQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLF 249
                  |...|:|..:|||.:||:|.:..||:|||.|.|::|.|.::|||:.||..:...:||||
Zfish   147 ------CGTACEGLFLSLAFKLLILLLAGWALFMRPTRASLPGIAVFRALLGLLTLLLLLSYWLF 205

  Fly   250 YIVQVTNGAKIVVETGGDAVD--YKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRS 312
            :      |.:|:     |:.|  |:.:|.:|.:.||.||||||:||||||:||.|||:.:.::||
Zfish   206 F------GVRIL-----DSQDDNYQGIVQFAVSLVDALLFIHYLAVVLLEIRHLQPCFSLCVVRS 259

  Fly   313 PDGVSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVS 377
            .||.:..|.:|||||||||:..|:|||.||.:.||.|    ::.:||:..|.....|.|.|||..
Zfish   260 TDGETHHYNMGQLSIQRAALVTLEHYYKDFTVHNPAL----LTAAKSRAAKHLAGLKVYNVDGAG 320

  Fly   378 NSQQQSQSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNE---P 439
            :....:||||.:||.||:||:||||.:|||.|::|||:||:|||:.|.||||||::|:.:|   .
Zfish   321 SDAATAQSRAKMAAAARQRDTSHNELYYEEAEHDRRVRKRKARLVVAVEEAFTHVRRLQDEEKKK 385

  Fly   440 APALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTE 504
            .|...:||:|||.|:|||||||||||||.||||..|:.:||..|||.|:.::::|:||||.|||.
Zfish   386 PPGDEMDPREAAQAIFPSMARALQKYLRTTRQQHCHSMDSIQAHLAFCITNNMTPKAFLESYLTA 450

  Fly   505 SPVMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSN 569
            .|.:|..:|....:.|:|:.:..|:.|:.|...|||..:|.||:||...:||..|:||.|.|||:
Zfish   451 GPTLQYGRESSQTRHWTLVSEASVTSPLRNGSEFQLKSSDFSLVVTSKTIPHLKLSEEYVHPKSH 515

  Fly   570 KFVLKLNSETSV 581
            ||||:|.|||||
Zfish   516 KFVLQLQSETSV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	44..581	CDD:284135	233/552 (42%)
vangl1	NP_991313.1	Strabismus	27..527	CDD:284135	231/549 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592399
Domainoid	1	1.000	428	1.000	Domainoid score	I581
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1675
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		otm24581
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	O	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800