Protein Alignment Vang and vangl2

DIOPT Version :10

• Sequence 1: NP_001260819.1
• Gene: Vang / 35922
• FlyBaseID: FBgn0015838
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_705960.1
• Gene: vangl2 / 245949
• ZFINID: ZDB-GENE-020507-3
• Length: 526
• Species: Danio rerio
• Alignment Length: 597
• Identity: 253/597 - (42%)
• Similarity: 348/597 - (58%)
• Gaps: 87/597 - (14%)

  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGF 65
            |:|||..|.:|.:|..||:...                    ||:|       |..|.|||....
Zfish     1 MDNESQYSGYSYKSSHSRSSRK--------------------HRDR-------RDRHRSKSRDSS 38

  Fly    66 QRGDMA--------PYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMED 122
            .|||.:        |...:.:..||              .:|:||||.||.||| |||.|:|.||
Zfish    39 SRGDKSVTIQAPGEPLLDAESTRGD--------------DRDDNWGETTTVVTG-TSEHSVSNED 88

  Fly   123 INNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQ 187
            :... .:|.:......|||:.......:||..|..:|:|.:::|.:.:              |..
Zfish    89 LTRA-SKELEDSSPLECRRFAGPIVSGVLGLFALLTPLAFLLLPQLLW--------------RDS 138

  Fly   188 LLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIV 252
            |..|...|:|..||||.:||:|.|..||:|:|.:.:|:||.|::|.|::.||.:...:|||||.|
Zfish   139 LEPCGTPCEGLYVSLAFKLLVLLISSWALFLRPSRSTLPRFFVFRCLLMALVFLFVASYWLFYGV 203

  Fly   253 QVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVS 317
            :|....:         .||:.:||||.:.||.||||.|:|:||||:||.:|.:.:|::|:.||.|
Zfish   204 RVLEPRE---------RDYRGIVGYAVSLVDALLFIQYLALVLLEVRHLRPAFCLKVVRTTDGAS 259

  Fly   318 RSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQ 382
            |.|.:|.|||||||||||.|||.|||::||.|..:|    ||..:|..:.||.|.: |..||...
Zfish   260 RFYNVGHLSIQRAAVWVLDHYYTDFPVYNPALLNLP----KSILSKKMSGFKVYSL-GEENSTNN 319

  Fly   383 S--QSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPAPALP- 444
            |  ||||::||.|||||:||||.:|||.|.:|||:||:|||:.|.|||||||||:.::.|.|.|
Zfish   320 STGQSRAMIAAAARRRDNSHNEYYYEEAEMDRRVRKRKARLVVAVEEAFTHIKRLQDDEAAASPK 384

  Fly   445 -----LDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTE 504
                 :||:|||.|:|..||||:|||||.|||||.|:.|||:.||..|:.|:::|:||||.|||.
Zfish   385 HPREVMDPREAAQAIFAPMARAMQKYLRTTRQQPYHSMESIISHLQFCITHNMTPKAFLERYLTP 449

  Fly   505 SPVMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSN 569
            .|.||.::|....:.|:|:.:|.|:..:.....|.|.:.|.:|:|||..||..||.||.:||||:
Zfish   450 GPTMQYQRENGRGRQWTLVSEEPVTAALRQGLVFSLRRLDFALVVTVTPLPFLNLGEEFIDPKSH 514

  Fly   570 KFVLKLNSETSV 581
            |||::|.|||||
Zfish   515 KFVMRLQSETSV 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	43..581	CDD:461971	242/553 (44%)
vangl2	NP_705960.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		40/136 (29%)
		Strabismus	41..526	CDD:461971	233/528 (44%)
		PDZ-binding. /evidence=ECO:0000255	523..526		2/2 (100%)