DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vang and vangl2

DIOPT Version :9

Sequence 1:	NP_001260819.1	Gene:	Vang / 35922	FlyBaseID:	FBgn0015838	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_705960.1	Gene:	vangl2 / 245949	ZFINID:	ZDB-GENE-020507-3	Length:	526	Species:	Danio rerio

Alignment Length:	597	Identity:	253/597 - (42%)
Similarity:	348/597 - (58%)	Gaps:	87/597 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGF 65
            |:|||..|.:|.:|..||:...                    ||:|       |..|.|||....
Zfish     1 MDNESQYSGYSYKSSHSRSSRK--------------------HRDR-------RDRHRSKSRDSS 38

  Fly    66 QRGDMA--------PYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMED 122
            .|||.:        |...:.:..||              .:|:||||.||.||| |||.|:|.||
Zfish    39 SRGDKSVTIQAPGEPLLDAESTRGD--------------DRDDNWGETTTVVTG-TSEHSVSNED 88

  Fly   123 INNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQ 187
            :... .:|.:......|||:.......:||..|..:|:|.:::|.:.:              |..
Zfish    89 LTRA-SKELEDSSPLECRRFAGPIVSGVLGLFALLTPLAFLLLPQLLW--------------RDS 138

  Fly   188 LLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIV 252
            |..|...|:|..||||.:||:|.|..||:|:|.:.:|:||.|::|.|::.||.:...:|||||.|
Zfish   139 LEPCGTPCEGLYVSLAFKLLVLLISSWALFLRPSRSTLPRFFVFRCLLMALVFLFVASYWLFYGV 203

  Fly   253 QVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVS 317
            :|....:         .||:.:||||.:.||.||||.|:|:||||:||.:|.:.:|::|:.||.|
Zfish   204 RVLEPRE---------RDYRGIVGYAVSLVDALLFIQYLALVLLEVRHLRPAFCLKVVRTTDGAS 259

  Fly   318 RSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQ 382
            |.|.:|.|||||||||||.|||.|||::||.|..:|    ||..:|..:.||.|.: |..||...
Zfish   260 RFYNVGHLSIQRAAVWVLDHYYTDFPVYNPALLNLP----KSILSKKMSGFKVYSL-GEENSTNN 319

  Fly   383 S--QSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPAPALP- 444
            |  ||||::||.|||||:||||.:|||.|.:|||:||:|||:.|.|||||||||:.::.|.|.|
Zfish   320 STGQSRAMIAAAARRRDNSHNEYYYEEAEMDRRVRKRKARLVVAVEEAFTHIKRLQDDEAAASPK 384

  Fly   445 -----LDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTE 504
                 :||:|||.|:|..||||:|||||.|||||.|:.|||:.||..|:.|:::|:||||.|||.
Zfish   385 HPREVMDPREAAQAIFAPMARAMQKYLRTTRQQPYHSMESIISHLQFCITHNMTPKAFLERYLTP 449

  Fly   505 SPVMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSN 569
            .|.||.::|....:.|:|:.:|.|:..:.....|.|.:.|.:|:|||..||..||.||.:||||:
Zfish   450 GPTMQYQRENGRGRQWTLVSEEPVTAALRQGLVFSLRRLDFALVVTVTPLPFLNLGEEFIDPKSH 514

  Fly   570 KFVLKLNSETSV 581
            |||::|.|||||
Zfish   515 KFVMRLQSETSV 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	44..581	CDD:284135	241/552 (44%)
vangl2	NP_705960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		40/136 (29%)
		Strabismus	41..526	CDD:284135	233/528 (44%)
		PDZ-binding. /evidence=ECO:0000255	523..526		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592398
Domainoid	1	1.000	428	1.000	Domainoid score	I581
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1675
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		otm24581
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800