DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8777 and TTC37

DIOPT Version :9

Sequence 1:	NP_610452.2	Gene:	CG8777 / 35921	FlyBaseID:	FBgn0033376	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_055454.1	Gene:	TTC37 / 9652	HGNCID:	23639	Length:	1564	Species:	Homo sapiens

Alignment Length:	1304	Identity:	361/1304 - (27%)
Similarity:	587/1304 - (45%)	Gaps:	127/1304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KESKALIKDIRETIKLGKHAEAIPKCQRLLKSEPENAMGYLLLGAAYQNIDKAEAAKNLRQCIKC 69
            ||.|..:|..|:.|:..::.||:..|:.:||.|..|...::.:|.|...:::.:.|::   ..|.
Human     4 KEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQS---AYKK 65

  Fly    70 TDGPAPAALL---GLAN-------CAPSNELPEIYDQLADLQPEQSLNYW----EKLFNL----A 116
            .....|..||   ||||       ....::||.:|.:|.||........|    :||.:|    .
Human    66 AAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEK 130

  Fly   117 SDSNVAPFCFTVLKKR-VQDTENGNFTKIQEYLGRIWVSNDFEIAPEDTQLYKTTMEALLQNSE- 179
            ....||.....::|.| .|..||....::...|.:....:..:...|..||..|..|..|..|:
Human   131 KHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQLLFTAFENALGLSDK 195

  Fly   180 -PSA-RSVVYKRYLKWLYKKQDYETCVRHAC-NMTESHPKDVYGFEWICKTYCEHHEQSEIVSWQ 241
             ||. ..|:|:.:::.|.|.......::.|| .|...:|...|..|.:|....|          .
Human   196 IPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPLEVLCLHLIE----------S 250

  Fly   242 QELRHPIQVYAEQLLELNPNSNLALL---VKAL-DLFAEGQVVASRQLALQAQKSQPA-----YK 297
            ..|....|.|..:|:|::..|...|:   :||| |...|..|   |.|. :..|..|.     |.
Human   251 GNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAV---RNLT-EGLKESPVCTSGWYH 311

  Fly   298 VTLELLARIHMELGAY---KLALQLWQEIGQE-NDAYA--LCLSHEKGVSKLR--------EAVT 348
            :. |...::|....|.   ..||::...:|.. |..|.  ||| |.|..:.::        ||:.
Human   312 LA-EAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCL-HLKAEALIKLSDYDSSEEAIR 374

  Fly   349 ILQTLENSEGNI------KSLA------------------RCYFKLGELHLLKDLPLDDLTKAEF 389
            .|..:.::: ||      ||||                  ..|..|.|:|.|:  .|...||.::
Human   375 TLDQISDAD-NIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALE--ALIHFTKKDY 436

  Fly   390 VLSP---SEALQEIADCKTFEAYLLCGKLHMAL-----KNYSDALNYVLKATRLRPHFAECFDYL 446
            :.:.   ..||::  |.:..|.:...|..:..:     |:.:.||.:.|||.||..:..:.|.||
Human   437 LQAEKCFQRALEK--DTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYL 499

  Fly   447 GKLYPLATGDFSRARKCYEKCISLNPLAEEAVDALSFIYQEQGEEELNETLLLNTLSHLGSNESI 511
            |..|....||.:|||.||.|...|:....|:..|...:..|..:.|: ...:|.|::...|..:.
Human   500 GHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEM-ALAILTTVTQKASAGTA 563

  Fly   512 RLQY-KLGLHFSHVKKWDSAIQCFRIAIKNDSRCISYWESLGDAYAGRGSYNSAIRVFQKILELS 575
            :..: :.||::....:...|:...:.|::.|.:..:.|||||:||..||.|.:|::.|.|..||:
Human   564 KWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELN 628

  Fly   576 PENNYALLQIASVKTTIRMYTESIEDYDTLLQRNPTYLPGLRGAAEAHIGIANSLKSQNLYGRSK 640
            ||:.|::.::|:::..:..|.|::..|..::::...|:|.|:|..|.|:.:|.:.....|.|::.
Human   629 PESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAV 693

  Fly   641 AHFQLALEHLQSAFLQREAQGMVWLWRLSANIFVQTAQLPHSLANLDVAGNLAKREEPIAYLSRK 705
            .:.:.|||:...| ||..|. :..||:|:.:.......:..|..|:.|.|.|..::|....|.:.
Human   694 DYIEKALEYFTCA-LQHRAD-VSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKN 756

  Fly   706 DLLQLAQRFYLCALKLKQNTYLWYELSLASYYSAILIPE------DANGHLETATKACKMAIKEC 764
            :||.|..|.|..||||...:..|.:|.:..|..|..:.|      |....||.:....|.|::..
Human   757 ELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLD 821

  Fly   765 SNRWQNWNLLGVINMNSENENLPLAQHCFIQAVVLEKKCYTAWTNLGVLYIKLNEVRLANEAFTR 829
            ||....||.|||:...|...|..|||||||:::..|:....|||||||||:....:..|:|||..
Human   822 SNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKM 886

  Fly   830 AQQSSPVYANAWIGQAMVAELIGDREEAFDLFRHCQQFDYHPEAALGFAHWVCEMLSTPGSFDKP 894
            ||...|.|...|||||::||.:|. .:..|||||..:.:.|.|.|||:|:|||..|....:.:..
Human   887 AQSLDPSYLMCWIGQALIAEAVGS-YDTMDLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETE 950

  Fly   895 RIKHAIEHMYADVLALDAINWYVQNEETDATPASLSFQGFLYARKNLYRQAIEAFTRACKLCEPG 959
            ..::.|..|.|...|...:|.||:..:..| || .:..|:|.....|.::|..|:.||..|.:..
Human   951 LYQYNILQMNAIPAAQVILNKYVERIQNYA-PA-FTMLGYLNEHLQLKKEAANAYQRAILLLQTA 1013

  Fly   960 ADRDK---LYTNLGYLYLKIDQPEQAAHALNTVAHATFKPIIGLAQAYYLAGQLQESYSIYNSVL 1021
            .|:|.   ...|.|.|.....:.::|..|..:......:.|||.|.|.::.|..:||...|...|
Human  1014 EDQDTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERAL 1078

  Fly  1022 GNVVDHGDDKAATILVAMASMIYDFQGEAD-TKTLLYQCVLLKEVPIQALFSALALGILHRDNAL 1085
             ::|:...|| |.||.|:|...|. ||:.| .||||::|.:|||...::|.:..|||:..:|..|
Human  1079 -SIVESEQDK-AHILTALAITEYK-QGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATL 1140

  Fly  1086 IHTILTELNAYAFKKEYCADISYLTAHYILINEGARRALCYLQTRIRMFPNSRSLRSVVLKFLLD 1150
            ....|.||..:...|:.......||:....:...:......:...:...|...:|.|::.:.:..
Human  1141 SKAALNELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLSRVVAQ 1205

  Fly  1151 YFSDDQSYRLATSNMGRITLTLGHTKQQNSILASEEALTTIYASQAVSAVDKTCSMKLLQRAILL 1215
            |...:....:...|:..| |...|.|:  ::|.:  |:..:....:.:..:|..::|.:|:|.||
Human  1206 YAQRNAKGGVVAGNVAHI-LDSNHGKK--ALLYT--AVNQLAMGSSSAEDEKNTALKTIQKAALL 1265

  Fly  1216 SPTD 1219
            ||.|
Human  1266 SPGD 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8777	NP_610452.2	TPR_11	18..68	CDD:290150	11/49 (22%)
		TPR repeat	40..69	CDD:276809	4/28 (14%)
		TPR repeat	262..292	CDD:276809	10/33 (30%)
		TPR repeat	297..322	CDD:276809	5/27 (19%)
		TPR repeat	361..398	CDD:276809	13/57 (23%)
		TPR_11	407..472	CDD:290150	24/69 (35%)
		TPR repeat	407..434	CDD:276809	8/31 (26%)
		TPR repeat	439..470	CDD:276809	13/30 (43%)
		TPR_11	510..576	CDD:290150	20/66 (30%)
		TPR repeat	511..539	CDD:276809	4/28 (14%)
		TPR repeat	544..574	CDD:276809	13/29 (45%)
		TPR_11	548..610	CDD:290150	22/61 (36%)
		TPR repeat	579..607	CDD:276809	5/27 (19%)
		TPR repeat	620..648	CDD:276809	6/27 (22%)
		TPR repeat	771..798	CDD:276809	14/26 (54%)
		TPR repeat	803..833	CDD:276809	15/29 (52%)
		TPR_11	806..868	CDD:290150	30/61 (49%)
		TPR repeat	838..866	CDD:276809	13/27 (48%)
		TPR repeat	926..954	CDD:276809	9/27 (33%)
		TPR_11	932..989	CDD:290150	15/59 (25%)
		TPR repeat	962..989	CDD:276809	6/29 (21%)
		TPR repeat	994..1021	CDD:276809	9/26 (35%)
TTC37	NP_055454.1	TPR 1	6..39		10/32 (31%)
		TPR_16	10..72	CDD:290168	14/64 (22%)
		TPR repeat	39..69	CDD:276809	5/32 (16%)
		TPR 2	40..73		5/35 (14%)
		TPR repeat	116..144	CDD:276809	5/27 (19%)
		TPR 3	272..305		11/36 (31%)
		TPR repeat	275..300	CDD:276809	9/28 (32%)
		TPR_11	278..335	CDD:290150	16/61 (26%)
		TPR repeat	305..335	CDD:276809	6/30 (20%)
		TPR 4	307..339		6/32 (19%)
		PEP_TPR_lipo	322..1272	CDD:274350	278/968 (29%)
		TPR repeat	340..374	CDD:276809	10/34 (29%)
		TPR 5	386..419		5/32 (16%)
		TPR repeat	388..414	CDD:276809	4/25 (16%)
		TPR 6	420..453		9/36 (25%)
		TPR repeat	420..448	CDD:276809	7/29 (24%)
		TPR repeat	453..488	CDD:276809	8/34 (24%)
		TPR 7	455..492		10/36 (28%)
		TPR 8	493..527		14/33 (42%)
		TPR repeat	493..522	CDD:276809	13/28 (46%)
		TPR repeat	530..555	CDD:276808	5/25 (20%)
		TPR 9	564..597		5/32 (16%)
		TPR repeat	566..592	CDD:276809	4/25 (16%)
		TPR repeat	597..627	CDD:276809	13/29 (45%)
		TPR 10	598..631		16/32 (50%)
		TPR repeat	632..660	CDD:276809	5/27 (19%)
		TPR 11	633..665		5/31 (16%)
		TPR repeat	666..701	CDD:276809	9/34 (26%)
		TPR 12	679..713		10/35 (29%)
		TPR repeat	776..819	CDD:276809	10/42 (24%)
		TPR 13	790..824		8/33 (24%)
		TPR repeat	824..856	CDD:276809	14/31 (45%)
		TPR 14	826..860		15/33 (45%)
		TPR 15	861..894		16/32 (50%)
		TPR_1	861..894	CDD:278916	16/32 (50%)
		TPR repeat	861..887	CDD:276809	13/25 (52%)
		TPR repeat	979..1009	CDD:276809	10/31 (32%)
		TPR 16	980..1013		11/34 (32%)
		TPR 17	1020..1054		5/33 (15%)
		TPR repeat	1020..1044	CDD:276809	5/23 (22%)
		TPR repeat	1054..1079	CDD:276809	10/25 (40%)
		TPR 18	1056..1084		9/28 (32%)
		TPR 19	1326..1359
		TPR 20	1400..1433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151629
Domainoid	1	1.000	107	1.000	Domainoid score	I6528
eggNOG	1	0.900	-	-		E1_KOG1127
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40966
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2152
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59463
OrthoDB	1	1.010	-	-		D347760at2759
OrthoFinder	1	1.000	-	-		FOG0003468
OrthoInspector	1	1.000	-	-		oto91073
orthoMCL	1	0.900	-	-		OOG6_103307
Panther	1	1.100	-	-	LDO	PTHR15704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1342
SonicParanoid	1	1.000	-	-		X4459
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800