DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8777 and SKI3

DIOPT Version :9

Sequence 1:NP_610452.2 Gene:CG8777 / 35921 FlyBaseID:FBgn0033376 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_015515.1 Gene:SKI3 / 856319 SGDID:S000006393 Length:1432 Species:Saccharomyces cerevisiae


Alignment Length:1437 Identity:284/1437 - (19%)
Similarity:530/1437 - (36%) Gaps:338/1437 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VKESKALIKDIRETIKLGKHAEAIPKCQRL----LK-------------SEPENAMGYLLLGAAY 51
            :|:.::.::.|.: |||.|...  |.||:.    ||             |.|::|:  |.|....
Yeast   118 LKQEQSQVELIND-IKLLKKTH--PDCQKAFYQHLKPGSLMAETIGRHLSTPQDAL--LNLIKIL 177

  Fly    52 QNIDKAEAAKNLRQ---CIKCTDGPAPAALLGLA-NCAPSNELPEIYDQ----LADLQPEQSL-N 107
            .||:..|..|.|.|   .:|.:|......|...: ....::|:.::|:|    |||.|....: |
Yeast   178 SNIETTEIGKTLSQNRLKLKASDPDYQIKLNSFSWEIIKNSEIDQLYNQLVNILADDQKRSEIEN 242

  Fly   108 YWEKLFNLASDSNVAPFCFTVLKKRVQDTENGNFTKIQEYLGRIWVSNDFEIAPEDTQLYKTTME 172
            .|            ..:...|||....|.:...|||::|.:..:.:.|...:.........|..|
Yeast   243 QW------------LEYRIKVLKSMPLDVKKDFFTKVKEMVEDMVLVNHQSLLAWQKYFEWTDYE 295

  Fly   173 ALLQNSEPSARSVVYKRYLK---------WL---------------------YKKQDYETCVRHA 207
            . |.|.:.......:|::.|         ||                     :||.:.||.::..
Yeast   296 D-LDNMDAPLIIKYFKKFPKDPLAMILYSWLSSKLSKYDIKSLESANKPPEGHKKTEKETDIKDV 359

  Fly   208 CNMTESHPKDVYGFEWICKTYCEHHEQSEIVSWQQE-----------LRHPIQVYAEQLLELNPN 261
            ....|...||....|...:...|..:|.|.....:|           ....:.|..|.:::...|
Yeast   360 DETNEDEVKDRVEDEVKDRVEDEVKDQDEEAKEDEEEDLDDIEIGLLEEEVVTVLTENIVKCKNN 424

  Fly   262 SNLALLVKALDLFAEGQVVASR------QLALQAQKSQPAYKVTLELLA------RIHMELGAYK 314
                             ::|.|      .|..:.:.:.|..|..:.|:|      .:|:.|...:
Yeast   425 -----------------ILAHRILCQYYLLTKEYEAALPYIKNGISLIAYNIKDLGVHLPLTKRE 472

  Fly   315 LALQL-----WQEIGQENDA----YALCLSHE---------KGV-----SKLREAVTIL-QTLEN 355
            .:|.|     :.:..::::|    |...||.:         ||:     ...::|:|:| |..|.
Yeast   473 FSLDLATVYTYVDAPKDHNAALKLYDNILSGDFSNIQAKMGKGIIFIERKNWKDAMTLLTQVHEQ 537

  Fly   356 SEGNIKSLARCYFKLGEL-----------HLLKDLPLDDLTKAEFVLSPSEALQEIADCKTFEAY 409
            |..|::.|:...:....:           .::|.:...||...:|     .||......|   .|
Yeast   538 SPNNLEVLSELSWSKAHMGYMDEALAGLDTVIKGIKGMDLRSIDF-----RALNLWRQAK---VY 594

  Fly   410 LLCGKLHMAL-----KNYSDALNYVLKATRLRPHFAECFDYLGKLYPLATGDFSRARKCYEKCIS 469
            ::   .|.::     :|...|...::::.::...||..|..||.:|.....|..||.|||.|...
Yeast   595 IM---KHASINDAKQENVKCAFKLLIQSIKILDTFAPGFSTLGDIYCHYYKDHLRAFKCYFKAFD 656

  Fly   470 LNPLAEEAVDALSFIYQEQGEEELNETLLLNTLSHLGSNESIRLQYK--------LGLHFSHVKK 526
            |:.....|...::..|..:...:...::    .|.|...|..:.:.:        :|:  :|::|
Yeast   657 LDAGDYTAAKYITETYASKPNWQAASSI----ASRLIKGEKAKAELRSNNWPFRVVGI--AHLEK 715

  Fly   527 WD--SAIQCFRIAIKNDSRCISYWESLGDAYAGRGSYNSAIRVFQKILELSPENNYALLQIASVK 589
            .:  .:|:.|:.|::.|...:..|..||.||...|...::|:||.|.::|.|.:.:|....|...
Yeast   716 QEESDSIEWFQSALRVDPNDVESWVGLGQAYHACGRIEASIKVFDKAIQLRPSHTFAQYFKAISL 780

  Fly   590 TTIRMYTESIEDYDTLLQRNPTYLPGLRGAAEAHIGIANSLKSQNLYGRSKAHFQLALEHLQSAF 654
            ..:..|.||::..:.:.|...|......|..|..:..:..|.||....:|.:..:..:|.::...
Yeast   781 CDVGEYLESLDILEKVCQEAATEESFQIGLVEVLMRCSLDLYSQGFLLKSVSIAKDTIERIKIII 845

  Fly   655 LQREAQG-MVWLW-----RLSANIFVQTAQLP-HSLANLDVAGNLAKREE----------PIAYL 702
            .:.:.:. .||::     ||...|..:...|| .||.::......:..||          .:...
Yeast   846 SELKCENQQVWIYLSQVLRLFIWIESKVDTLPVESLVSIFENSQFSGSEEIDSVDNIKIDTLLDS 910

  Fly   703 SRKDLLQLAQRFYLCALKLK-------------QNTYLWYELSLASYYSAILIPEDANGHLETAT 754
            :..|.:.:|.:|.:.|.|..             :.:| ||.:.::...:.|.:.|..  :.:.|.
Yeast   911 TTDDNVSIACKFLILASKYSVSDQKFTDIAGTVRASY-WYNIGISELTAFITLKEPQ--YRDAAI 972

  Fly   755 KACKMAIKECSNRWQNWNLLGVINMNSENENLPLAQHCFIQAVVLEKKCYTAWTNLGVLYIKLNE 819
            .|.|.:|:..||..:.|..||:..|:.   |..::|||||:|..||.|....|.||.:|.:|..:
Yeast   973 FAFKKSIQLQSNTSETWIGLGIATMDI---NFRVSQHCFIKATALEPKATNTWFNLAMLGLKKKD 1034

  Fly   820 VRLANEAFTRAQQSSPVYANAWIGQAMVAELIGDREEAFDLFRHCQQFDYHPEAALGFAHWVCEM 884
            ...|.:...:.|..:|..::.|:|.|::.|..||...:..||.|            .|      :
Yeast  1035 TEFAQQVLNKLQSLAPQDSSPWLGMALILEEQGDIIGSSKLFAH------------SF------I 1081

  Fly   885 LSTPGSFDKPRIKHAIEHMYADVLALDAINWYVQNEETD------ATPASLSFQGFL-------- 935
            ||...|       .|.:.|||..:..:.||  ..::|.|      .|.||::.:.|.        
Yeast  1082 LSNGRS-------KAAQFMYAKNVLENHIN--NGDDERDIETVEKLTTASIALEQFFKKSPDSQF 1137

  Fly   936 --------YARKNLYRQAIEAFTRACKLCEPGADRD-----------------KLYTNLGYLYLK 975
                    ..|.:.|..|.|...|...:.|...::.                 :::..||...|.
Yeast  1138 ALQCALLTLERLHHYENANELANRLIGILEKKFEKTQDERELFNFAIIKGQFARIHLGLGNFELS 1202

  Fly   976 IDQPEQAAHALNTVA-HATFKPIIG----LAQAYYLAGQLQESYSIYNSVLGNVVDHGDDKAATI 1035
            |:..:.:...::..: ..:.|..|.    |..:|:......::.:.:..:|....|     :..:
Yeast  1203 IENADLSQGIISESSDEKSMKTKISNHICLGLSYFFLNDFDQTLNQFQELLSISKD-----SKHL 1262

  Fly  1036 LVAMASMIYDFQGEADTKTL----LYQCVLLKEVPIQALFSALALGILHRDNALIHTILTELNAY 1096
            :|.:|.::||. ||:|||.:    |.:.:......:....:..|:.||......:..||.||.|.
Yeast  1263 VVLIAKVLYDV-GESDTKEIALQELTEYIATSGADLLVTLTIAAMSILDDKREDLSIILEELKAL 1326

  Fly  1097 AFKKEYC---ADISYLTAHY---ILINEGARRALCYLQTRIRMFPNSRSLRSVVLKFLLDYFSDD 1155
            ...|:..   .|..||....   :..|:..::.   .|.....|||:       || :.:....:
Yeast  1327 PLSKQIIDKHKDAPYLIEEITKRLYRNDTGKQV---WQRSAYFFPNN-------LK-VWERLDKN 1380

  Fly  1156 QSYRLATSNMGRITLTLGHTKQQNSILASEEALTTIYASQAVSAVDKTCSMKLLQRAILLSPTDQ 1220
            ...|:|::...::|               .|.::.:|.        ::.:::.:||.:.|.|.:.
Yeast  1381 IQRRIASNGQNKVT---------------AEEMSKLYC--------ESKNLRSIQRGMFLCPWNV 1422

  Fly  1221 RARQLLS 1227
            .|.:.|:
Yeast  1423 TAVKALN 1429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8777NP_610452.2 TPR_11 18..68 CDD:290150 20/69 (29%)
TPR repeat 40..69 CDD:276809 9/31 (29%)
TPR repeat 262..292 CDD:276809 3/35 (9%)
TPR repeat 297..322 CDD:276809 7/35 (20%)
TPR repeat 361..398 CDD:276809 6/47 (13%)
TPR_11 407..472 CDD:290150 18/69 (26%)
TPR repeat 407..434 CDD:276809 4/31 (13%)
TPR repeat 439..470 CDD:276809 13/30 (43%)
TPR_11 510..576 CDD:290150 18/75 (24%)
TPR repeat 511..539 CDD:276809 6/37 (16%)
TPR repeat 544..574 CDD:276809 10/29 (34%)
TPR_11 548..610 CDD:290150 18/61 (30%)
TPR repeat 579..607 CDD:276809 5/27 (19%)
TPR repeat 620..648 CDD:276809 5/27 (19%)
TPR repeat 771..798 CDD:276809 11/26 (42%)
TPR repeat 803..833 CDD:276809 7/29 (24%)
TPR_11 806..868 CDD:290150 17/61 (28%)
TPR repeat 838..866 CDD:276809 9/27 (33%)
TPR repeat 926..954 CDD:276809 8/43 (19%)
TPR_11 932..989 CDD:290150 11/89 (12%)
TPR repeat 962..989 CDD:276809 4/43 (9%)
TPR repeat 994..1021 CDD:276809 4/30 (13%)
SKI3NP_015515.1 TPR repeat 7..32 CDD:276809
TPR repeat 37..76 CDD:276809
TPR_22 151..241 CDD:408603 21/91 (23%)
PEP_TPR_lipo <412..>836 CDD:274350 90/457 (20%)
TPR repeat 507..537 CDD:276809 6/29 (21%)
TPR repeat 542..570 CDD:276809 1/27 (4%)
PEP_TPR_lipo 710..>1269 CDD:274350 124/598 (21%)
TPR repeat 735..765 CDD:276809 10/29 (34%)
TPR repeat 770..798 CDD:276809 5/27 (19%)
TPR repeat 945..980 CDD:276809 8/37 (22%)
TPR repeat 986..1013 CDD:276809 11/29 (38%)
TPR repeat 1018..1048 CDD:276809 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344678
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1127
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 149 1.000 Inparanoid score I1134
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003468
OrthoInspector 1 1.000 - - oto100078
orthoMCL 1 0.900 - - OOG6_103307
Panther 1 1.100 - - LDO PTHR15704
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1342
SonicParanoid 1 1.000 - - X4459
TreeFam 00.000 Not matched by this tool.
1110.820

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