DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8777 and Ttc37

DIOPT Version :9

Sequence 1:	NP_610452.2	Gene:	CG8777 / 35921	FlyBaseID:	FBgn0033376	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_038959300.1	Gene:	Ttc37 / 294595	RGDID:	1306062	Length:	1568	Species:	Rattus norvegicus

Alignment Length:	1337	Identity:	368/1337 - (27%)
Similarity:	586/1337 - (43%)	Gaps:	189/1337 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KESKALIKDIRETIKLGKHAEAIPKCQRLLKSEPENAMGYLLLGAAYQNIDKAEAAKNLRQCIKC 69
            ||.|..:|..|:.|:..::.|.:..|:.:||.|.:|...::.:|.|...:.:.:.|:.   ..|.
  Rat     4 KEVKTALKSARDAIRNKEYKEVLKHCKTVLKQEKDNYNAWVFIGVAAAELGQPDQAQG---AYKK 65

  Fly    70 TDGPAPAALL---GLAN----CAPSN---ELPEIYDQLADLQPEQSLNYW----EKLFNLASDS- 119
            .....|..||   |||:    |...|   :||.:|.:|.||........|    :||.:|....
  Rat    66 AAELEPEQLLAWQGLASLYEKCNHINAKDDLPGVYRKLLDLYESVDKQKWCDVCKKLVDLYHQEK 130

  Fly   120 ---NVAPFCFTVLKKRVQDTENGNFTKIQEYLGRIW------VSNDFEIAPEDT-QLYKTTME-A 173
               .||...:.::|.|.:|..:      ::.|..:|      :|.|.|...::| |:..|..| |
  Rat   131 KHLEVARTWYRLIKARQEDGAD------RQELYELWRKLSQLLSEDAEDQNDETQQMLLTAFENA 189

  Fly   174 L-LQNSEPSA-RSVVYKRYLKWLYKKQDYETCVRHAC-NMTESHPKDVYGFEWICKTYC------ 229
            | |.::.||. ..|:|:.::::|.|.....|.::.|| .|...:|...|..|.|| .|.
  Rat   190 LDLADNVPSEDHQVLYRNFIQYLSKFPHEMTRLKKACEGMITMYPAVQYPLEVIC-LYLIDSGSL 253

  Fly   230 --EHHEQSEIVSWQQELRHPIQVYAEQLLELNPNSNLALLVKALDLFAEGQVVASRQLALQAQKS 292
              |.|:                 |..:|:|:|..|...|:...:....:.:...:.....:..|.
  Rat   254 TDEGHQ-----------------YCYKLVEMNSKSGPGLIGLGIRALQDKKYEDAISHLTEGLKE 301

  Fly   293 QP----AYKVTLELLARIHMELGAY---KLALQLWQEIG-------QENDAYALCLSHE------ 337
            .|    .:....|:..::|....|.   ..||:....:|       |:|    |||..:
  Rat   302 SPLCIAGWCHLAEVQVKVHRPKEAILSCNRALKTIDNLGASGGSLHQKN----LCLRLKAEALLK 362

  Fly   338 -KGVSKLREAVTILQTLENSEGN-----------------------IKSLARCYFKLGELHLLKD 378
             ...:.|.|||.||..|.:::..                       ::.|...|..|.|.|.|:
  Rat   363 LSDCASLEEAVHILDQLSDTDNTPGLLVLQGLACLNTGAIDKATKIMEDLVASYPDLSEAHALE- 426

  Fly   379 LPLDDLTKAEFV---LSPSEALQEIADCKTFE-----AYLLCGKLHMALKNYSDALNYVLKATRL 435
             .....||.::|   .|...||::.|:...:.     .|.|.|:  ...|:.:.|||:.|||.||
  Rat   427 -AYVHFTKKDYVQAETSFQRALEKDAEVAEYHYQLGLTYWLMGE--ETRKDRTKALNHFLKAARL 488

  Fly   436 RPHFAECFDYLGKLYPLATGDFSRARKCYEKCISLNPLAEE----AVDALSFIYQEQGEEELNET 496
            ..|..:.|.|||..|....||.:|||.||.|...|:....|    ||| ||.      |.|..||
  Rat   489 DAHMGKVFCYLGHYYRDVAGDRNRARGCYRKAFELDDSDAESGAAAVD-LSV------ELEDTET 546

  Fly   497 LL--LNTLSHLGSNESIRLQY-KLGLHFSHVKKWDSAIQCFRIAIKNDSRCISYWESLGDAYAGR 558
            .|  |..::...|:.:.:..: :.||::........|:...:.|::.|.:..:.|||||:||..|
  Rat   547 ALAILTAVTQKASSGAAKWAWLRRGLYYLKAGHHSQAVADLQAALRADPKDCNCWESLGEAYLSR 611

  Fly   559 GSYNSAIRVFQKILELSPENNYALLQIASVKTTIRMYTESIEDYDTLLQRNPTYLPGLRGAAEAH 623
            |||.:|::.|.:..||||::.|::.::|:::..:..|:|:|..|..::::...|:|.|:|..|.|
  Rat   612 GSYTTALKSFTRASELSPDSTYSVFKVAAIQQILGRYSEAIAQYQLIIKKEEDYVPALKGLGECH 676

  Fly   624 IGIANSLKSQNLYGRSKAHFQLALEHLQSAFLQREAQGMVWLWRLSANIFVQTAQLPHSLANLDV 688
            :.:..:.....|.|::..:.:.||.:...| ||..|. :..||:|..:.......:..:..|:.|
  Rat   677 LMLGKAALVDFLDGKAVDYVEQALGYFTRA-LQHRAD-VSCLWKLMGDACTCLHPVSPAKVNVRV 739

  Fly   689 AGNLAKREEPIAYLSRKDLLQLAQRFYLCALKLKQNTYLWYELSLASYYSAILIPE------DAN 747
            :|.|..::|....|.:.:||.|..|.|..||||...:..|.:|.:..|..|..:.|      |..
  Rat   740 SGALLGQQEGQEVLRKDELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSSMNDLT 804

  Fly   748 GHLETATKACKMAIKECSNRWQNWNLLGVINMN-----SENENLPLAQHCFIQAVVLEKKCYTAW 807
            ..||.:....|.|::..||....||.|||:...     |...|..|||||||:::..|:....||
  Rat   805 ELLEKSLHCLKKAVRLDSNNHLYWNALGVVTCYHVLYVSGVGNYALAQHCFIKSIQAEQINAAAW 869

  Fly   808 TNLGVLYIKLNEVRLANEAFTRAQQSSPVYANAWIGQAMVAELIGDREEAFDLFRHCQQFDYHPE 872
            |||||||:....:..|:|||..||...|.|...|||||::||.||. .|..|||||..:...|.|
  Rat   870 TNLGVLYLATENIEQAHEAFQMAQSLDPSYLLCWIGQALIAERIGS-YETMDLFRHTTELSMHTE 933

  Fly   873 AALGFAHWVCEMLSTPGSFDKPRIKHAIEHMYADVLALDAINWYVQNEETDATPASLSFQGFLYA 937
            .|:|:|:|||..|....:.:....::.|..|.|...|...:..||:..:..| || .:..|:|..
  Rat   934 GAIGYAYWVCTTLQDKSNRETELYQYNILQMNAVPAAQGVLCKYVERIQNYA-PA-FTMLGYLNE 996

  Fly   938 RKNLYRQAIEAFTRACKLCEPGADR---DKLYTNLGYLYLKIDQPEQAAHALNTVAHATFKPIIG 999
            ...|.|:|.||:.||..|.....|:   :....|.|.|...|...::|..|..:...|..:.|||
  Rat   997 HLQLKREAAEAYQRATALLHSAEDQHTYNVTVRNWGRLLCSIGDYDKALQAFKSTPLAELEDIIG 1061

  Fly  1000 LAQAYYLAGQLQESYSIYNSVLGNVVDHGDDKAATILVAMASMIYDFQGEAD-TKTLLYQCVLLK 1063
            .|.|.::.|..:||.:.|...| .|.....|| |.||.|||...|. ||:.| .|:||::|.:||
  Rat  1062 FALALFMKGLYKESSTAYERAL-TVCKSEQDK-AHILTAMAVTEYK-QGKMDAAKSLLFKCSILK 1123

  Fly  1064 EVPIQALFSALALGILHRDNALIHTILTELNAYAFKK-EY-----CADISYLTAHYILINEGARR 1122
            |...::|....|||:..:|..|....|.||..:..:| :|     .:.|..|..|.:.:.....:
  Rat  1124 EPTAESLQVLCALGLAMQDATLSKAALNELLKHIKQKNDYHRYLLTSAIYALQGHSVAVQRQVAK 1188

  Fly  1123 ALCYLQTRIRMFPNSRSLRSVVLKFLLDYFSDDQSYRLATSNMGRITLTLGHTKQQNSILASEEA 1187
            |       :...|...:|.|::.:.:..|...:       :..|.:..::.|....|.   .::|
  Rat  1189 A-------VHSNPADPALWSLLSRIVAQYTQQN-------AKGGAVAGSVAHILDSNH---GKKA 1236

  Fly  1188 LTTIYASQAV----SAVDK-TCSMKLLQRAILLSPTD 1219
            |.....:|..    :|.|| :.::|.:|:|..|||.|
  Rat  1237 LLYTAVNQLAMGGSTAEDKSSTALKTIQKAAFLSPDD 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8777	NP_610452.2	TPR_11	18..68	CDD:290150	10/49 (20%)
		TPR repeat	40..69	CDD:276809	4/28 (14%)
		TPR repeat	262..292	CDD:276809	2/29 (7%)
		TPR repeat	297..322	CDD:276809	5/27 (19%)
		TPR repeat	361..398	CDD:276809	11/39 (28%)
		TPR_11	407..472	CDD:290150	27/69 (39%)
		TPR repeat	407..434	CDD:276809	10/31 (32%)
		TPR repeat	439..470	CDD:276809	13/30 (43%)
		TPR_11	510..576	CDD:290150	20/66 (30%)
		TPR repeat	511..539	CDD:276809	4/28 (14%)
		TPR repeat	544..574	CDD:276809	13/29 (45%)
		TPR_11	548..610	CDD:290150	23/61 (38%)
		TPR repeat	579..607	CDD:276809	6/27 (22%)
		TPR repeat	620..648	CDD:276809	5/27 (19%)
		TPR repeat	771..798	CDD:276809	14/31 (45%)
		TPR repeat	803..833	CDD:276809	15/29 (52%)
		TPR_11	806..868	CDD:290150	32/61 (52%)
		TPR repeat	838..866	CDD:276809	15/27 (56%)
		TPR repeat	926..954	CDD:276809	11/27 (41%)
		TPR_11	932..989	CDD:290150	17/59 (29%)
		TPR repeat	962..989	CDD:276809	6/29 (21%)
		TPR repeat	994..1021	CDD:276809	9/26 (35%)
Ttc37	XP_038959300.1	PEP_TPR_lipo	<15..479	CDD:274350	107/498 (21%)
		TPR repeat	39..69	CDD:276809	5/32 (16%)
		TPR repeat	116..144	CDD:276809	5/27 (19%)
		TPR repeat	271..301	CDD:276809	2/29 (7%)
		PEP_TPR_lipo	278..>700	CDD:274350	109/436 (25%)
		TPR repeat	306..334	CDD:276809	4/27 (15%)
		TPR repeat	388..414	CDD:276809	1/25 (4%)
		TPR repeat	420..448	CDD:276809	8/29 (28%)
		TPR repeat	453..488	CDD:276809	10/36 (28%)
		TPR repeat	493..522	CDD:276809	13/28 (46%)
		TPR repeat	566..592	CDD:276809	4/25 (16%)
		PEP_TPR_lipo	568..>1428	CDD:274350	220/731 (30%)
		TPR repeat	597..627	CDD:276809	13/29 (45%)
		TPR repeat	632..660	CDD:276809	6/27 (22%)
		TPR repeat	666..708	CDD:276809	10/42 (24%)
		TPR repeat	776..819	CDD:276809	10/42 (24%)
		TPR repeat	824..861	CDD:276809	14/36 (39%)
		TPR repeat	866..892	CDD:276809	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345121
Domainoid	1	1.000	96	1.000	Domainoid score	I7180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40966
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2146
OMA	1	1.010	-	-		QHG59463
OrthoDB	1	1.010	-	-		D347760at2759
OrthoFinder	1	1.000	-	-		FOG0003468
OrthoInspector	1	1.000	-	-		oto98165
orthoMCL	1	0.900	-	-		OOG6_103307
Panther	1	1.100	-	-	LDO	PTHR15704
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4459
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910