DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8777 and Ttc37

DIOPT Version :9

Sequence 1:NP_610452.2 Gene:CG8777 / 35921 FlyBaseID:FBgn0033376 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_001074821.1 Gene:Ttc37 / 218343 MGIID:2679923 Length:1563 Species:Mus musculus


Alignment Length:1334 Identity:359/1334 - (26%)
Similarity:572/1334 - (42%) Gaps:188/1334 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KESKALIKDIRETIKLGKHAEAIPKCQRLLKSEPENAMGYLLLGAAYQNIDKAEAAKNLRQCIKC 69
            ||.|..:|..|:.|:..::.||:..|:.:||.|..|...::.:|.|...:::.:.|:.   ..|.
Mouse     4 KEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQG---AYKK 65

  Fly    70 TDGPAPAALL---GLAN----CAPSN---ELPEIYDQLADLQPEQSLNYW----EKLFNLASDS- 119
            .....|..||   |||:    |...|   :||.:|.:|.||........|    :||..|.... 
Mouse    66 AAELEPEQLLAWQGLASLYEKCNQVNAKDDLPGVYQKLLDLYESADRQKWCDVCKKLVALYHQEK 130

  Fly   120 ---NVAPFCFTVLKKRVQD-TENGNFTKIQEYLGRIWVSNDFEIAPEDTQLYKTTMEALLQNSE- 179
               .||.....::|.|.:| .:.....::...|.::...|..:...|..|:..|..|..|..:: 
Mouse   131 KHLEVARTWHRLIKTRQEDGADRQELYELWRKLSQLLAENIEDQNNETQQMLLTAFENALDLADN 195

  Fly   180 -PSA-RSVVYKRYLKWLYKKQDYETCVRHAC-NMTESHPKDVYGFEWIC-------KTYCEHHEQ 234
             ||. ..|:|:.:::.|.|.....|.::.|| .|...:|...|..|.||       ....|.|: 
Mouse   196 IPSEDHQVLYRNFIQCLSKFPHETTKLKKACEEMIAIYPTVQYPLEVICLYLIDSGSLTSEGHQ- 259

  Fly   235 SEIVSWQQELRHPIQVYAEQLLELNPNSNLALLVKALDLFAEGQVVASRQLALQAQKSQPAYKVT 299
                            |..:|:|:|..|...|:...:             :|||.:|.:.|.:..
Mouse   260 ----------------YCCKLVEMNSKSGPGLIGLGI-------------IALQDKKYEDAVRHL 295

  Fly   300 LELLAR--------IHMELGAYKL------------ALQLWQEIG-------QENDAYALCL--- 334
            .|.|..        .|:.....|:            ||:.....|       |:|    |||   
Mouse   296 TEGLKESPVCIAGWCHLAEAQVKMHRPKEAILSCNQALKTIDNFGASGGNLHQKN----LCLRLK 356

  Fly   335 -----------SHEKGVSKLRE--------AVTILQTL--------ENSEGNIKSLARCYFKLGE 372
                       |.|:.|..|.:        .:.:||.|        :.:...::.|...|..|.|
Mouse   357 AEALLKLSDGASSEEAVRTLDQVSDVDNTPGLLVLQGLACLNTGAVDKATKIMEDLVTSYPDLAE 421

  Fly   373 LHLLKDLPLDDLTKAEFV---LSPSEALQEIADCKTFE-----AYLLCGKLHMALKNYSDALNYV 429
            .|.|:...  ..||.::|   :|...||::.|:...:.     .|...|:  ...|:.:.||.:.
Mouse   422 AHALEGRV--HFTKKDYVQAEVSFQRALEKDAEVAEYHYQLGLTYWFMGE--ETRKDKTKALTHF 482

  Fly   430 LKATRLRPHFAECFDYLGKLYPLATGDFSRARKCYEKCISLNPLAEE----AVDALSFIYQEQGE 490
            |||.||..|..:.|.|||..|....||.:|||.||.|...|:....|    ||| ||.      |
Mouse   483 LKAARLDAHMGKVFCYLGHYYRDVAGDRNRARGCYRKAFELDDNDAESGAAAVD-LSL------E 540

  Fly   491 EELNETLL--LNTLSHLGSNESIRLQY-KLGLHFSHVKKWDSAIQCFRIAIKNDSRCISYWESLG 552
            .|..||.|  |..::...|..:.:..: :.||:.....:...|:...:.|::.|.:..:.|||||
Mouse   541 LEDTETALAILTAVTQKASAGAAKWAWLRRGLYHLKAGQHSQAVADLQAALRADPKDCNCWESLG 605

  Fly   553 DAYAGRGSYNSAIRVFQKILELSPENNYALLQIASVKTTIRMYTESIEDYDTLLQRNPTYLPGLR 617
            :||..||.|.:|::.|.|..||:|::.|::.::|:::..:..|:|:|..|..:::....|:|.|:
Mouse   606 EAYLSRGGYTTALKSFMKASELNPDSTYSVFKVAAIQQILGRYSEAIAQYQLIIKMKEDYVPALK 670

  Fly   618 GAAEAHIGIANSLKSQNLYGRSKAHFQLALEHLQSAFLQREAQGMVWLWRLSANIFVQTAQLPHS 682
            |..|.|:.:........|.|::..:.:.||.:...| ||..|. :..||:|..:.......:..|
Mouse   671 GLGECHLLLGKVALVDFLDGKAVDYVEQALGYFTRA-LQHRAD-VSCLWKLVGDACTCLHPVSPS 733

  Fly   683 LANLDVAGNLAKREEPIAYLSRKDLLQLAQRFYLCALKLKQNTYLWYELSLASYYSAILIPE--- 744
            ..::.|.|.|..::|....|.:::||.|..|.|..||||...:..|.:|.:..|.....:.|   
Mouse   734 KVHVHVLGALLGQKEGQEVLKKEELLSLGGRCYGRALKLMSTSNTWCDLGINYYRQVQHLAETGS 798

  Fly   745 ---DANGHLETATKACKMAIKECSNRWQNWNLLGVINMNSENENLPLAQHCFIQAVVLEKKCYTA 806
               |....||.:....|.|::..||...:||.|||:.......|..|||||||:::..|:....|
Mouse   799 SMSDLTELLEKSLHCLKKAVRLDSNNHLHWNALGVVACYRGVGNYALAQHCFIKSIQAEQINAAA 863

  Fly   807 WTNLGVLYIKLNEVRLANEAFTRAQQSSPVYANAWIGQAMVAELIGDREEAFDLFRHCQQFDYHP 871
            ||||||||:....:..|:|||..||...|.|...|||||::||.:|. .:..|||||..:...|.
Mouse   864 WTNLGVLYLATENIEQAHEAFKMAQSLDPSYLLCWIGQALIAERVGS-YDTMDLFRHTTELSMHT 927

  Fly   872 EAALGFAHWVCEMLSTPGSFDKPRIKHAIEHMYADVLALDAINWYVQNEETDATPASLSFQGFLY 936
            |.|:|:|:|||..|....:.:....::.|..|.|...|...:..||:..:..|  ::.:..|:|.
Mouse   928 EGAIGYAYWVCTTLQDKSNRETELYQYNILEMNAIPAAQGVLCKYVERIQNSA--SAFTMLGYLN 990

  Fly   937 ARKNLYRQAIEAFTRACKLCEPGADRDK---LYTNLGYLYLKIDQPEQAAHALNTVAHATFKPII 998
            ....|.::|.||:.||..|.....|::.   ...|.|.|...|...::|..|..:......:.||
Mouse   991 EHLQLKKEAAEAYQRATTLLHSAEDQNTYNVAVRNWGRLLCSIGDYDRAIQAFKSTPLVELEDII 1055

  Fly   999 GLAQAYYLAGQLQESYSIYNSVLGNVVDHGDDKAATILVAMASMIYDFQGEAD-TKTLLYQCVLL 1062
            |.|.|.::.|..:||.|.|...|. |.....|| |.||.|||.:.|. ||:.| .|:.|::|.:|
Mouse  1056 GFALALFMKGLYKESGSAYERALA-VCKSEQDK-AHILTAMAIVEYK-QGKMDAAKSFLFKCSIL 1117

  Fly  1063 KEVPIQALFSALALGILHRDNALIHTILTELNAYAFKK-EY--C---ADISYLTAHYILINEGAR 1121
            ||...::|.:..|||:..||..|....|.||..:..:: :|  |   :.|..|..|.:.:.....
Mouse  1118 KEPTAESLQALCALGLAMRDATLSKAALNELLKHIKRRNDYHSCLLMSAIYALQGHSVAVQRQVA 1182

  Fly  1122 RALCYLQTRIRMFPNSRSLRSVVLKFLLDYFSDDQSYRLATSNMGRITLTLGHTKQQNSILASEE 1186
            :|       :...|...:|.|::.:.:..|............|:..| |.|.|.|:.....|..:
Mouse  1183 KA-------VHSNPADPALWSLLSRIVAQYTQRSAKGGAVAGNVAHI-LDLNHGKKALLYTAVNQ 1239

  Fly  1187 ALTTIYASQAVSAVDKT-CSMKLLQRAILLSPTD 1219
                 .|..:.:|.||: .::|.:|:|..|||.|
Mouse  1240 -----LAMGSSTAEDKSNTALKTIQKAAFLSPDD 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8777NP_610452.2 TPR_11 18..68 CDD:290150 11/49 (22%)
TPR repeat 40..69 CDD:276809 4/28 (14%)
TPR repeat 262..292 CDD:276809 5/29 (17%)
TPR repeat 297..322 CDD:276809 6/44 (14%)
TPR repeat 361..398 CDD:276809 11/39 (28%)
TPR_11 407..472 CDD:290150 25/69 (36%)
TPR repeat 407..434 CDD:276809 8/31 (26%)
TPR repeat 439..470 CDD:276809 13/30 (43%)
TPR_11 510..576 CDD:290150 20/66 (30%)
TPR repeat 511..539 CDD:276809 4/28 (14%)
TPR repeat 544..574 CDD:276809 13/29 (45%)
TPR_11 548..610 CDD:290150 22/61 (36%)
TPR repeat 579..607 CDD:276809 6/27 (22%)
TPR repeat 620..648 CDD:276809 5/27 (19%)
TPR repeat 771..798 CDD:276809 13/26 (50%)
TPR repeat 803..833 CDD:276809 15/29 (52%)
TPR_11 806..868 CDD:290150 30/61 (49%)
TPR repeat 838..866 CDD:276809 13/27 (48%)
TPR repeat 926..954 CDD:276809 8/27 (30%)
TPR_11 932..989 CDD:290150 16/59 (27%)
TPR repeat 962..989 CDD:276809 6/29 (21%)
TPR repeat 994..1021 CDD:276809 10/26 (38%)
Ttc37NP_001074821.1 PEP_TPR_lipo 2..>673 CDD:274350 176/716 (25%)
TPR repeat 39..69 CDD:276809 5/32 (16%)
TPR repeat 74..110 CDD:276809 13/35 (37%)
TPR repeat 116..144 CDD:276809 5/27 (19%)
TPR repeat 271..301 CDD:276809 9/42 (21%)
TPR repeat 306..334 CDD:276809 3/27 (11%)
TPR repeat 388..414 CDD:276809 4/25 (16%)
PEP_TPR_lipo 420..1347 CDD:274350 262/881 (30%)
TPR repeat 420..448 CDD:276809 8/29 (28%)
TPR repeat 453..488 CDD:276809 8/36 (22%)
TPR repeat 493..522 CDD:276809 13/28 (46%)
TPR repeat 530..555 CDD:276808 11/31 (35%)
TPR repeat 566..592 CDD:276809 4/25 (16%)
TPR repeat 597..627 CDD:276809 13/29 (45%)
TPR repeat 632..660 CDD:276809 6/27 (22%)
TPR repeat 666..700 CDD:276809 7/33 (21%)
TPR repeat 776..819 CDD:276809 9/42 (21%)
TPR repeat 824..856 CDD:276809 13/31 (42%)
TPR repeat 861..887 CDD:276809 13/25 (52%)
TPR repeat 1358..1394 CDD:276809
TPR repeat 1399..1427 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841747
Domainoid 1 1.000 100 1.000 Domainoid score I7037
eggNOG 1 0.900 - - E1_KOG1127
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40966
Inparanoid 1 1.050 346 1.000 Inparanoid score I2302
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59463
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003468
OrthoInspector 1 1.000 - - oto94658
orthoMCL 1 0.900 - - OOG6_103307
Panther 1 1.100 - - LDO PTHR15704
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1342
SonicParanoid 1 1.000 - - X4459
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.790

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